|Year : 1982 | Volume
| Issue : 5 | Page : 463-464
Evaluation of anti-inflammatory drugs after cataract surgery
RL Agarwal, SK Lodha, CK Nagar, Shashi Bhasin
R. N.T Medical College, Udaipur, India
R L Agarwal
Medical College, Udaipur, Rajasthan
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Agarwal R L, Lodha S K, Nagar C K, Bhasin S. Evaluation of anti-inflammatory drugs after cataract surgery. Indian J Ophthalmol 1982;30:463-4
Inflammation following an operative trauma is a rule. Various drugs have been tried and used for the management of inflammatory reactions. In this study Ibuprofen; Oxyphenbutazone and Prednisolone were used to control the inflammatory reaction after cataract surgery. The error of judgement and prejudice in drawing the results was eliminated by making it a double blind study.
| Materials and methods|| |
In all 100 cases were selected who had no other occular or systemic pathology and were divided in 4 groups, each of 25 cases group one of control and group 2,3 & 4 were administered; Oxyphenbutazone 600 mg. Ibuprofen 600 mg and Prednisolone 20 mg daily in three divided doses respectively.
The drugs were given in identical prefilled and coded (A, B, C & D) capsules and same dose schedule was followed for all the cases.
An up to date record of each patient was maintained on separate case sheet. The results were evaluated statistically.
| Observations and discussion|| |
The parameters assessed were as follows
a) Discharge :--Discharge was recorded only in prednisolone group while not in other groups.
b) Lid Swelling :-Lid swelling was least in oxyphenbutazone and Ibuprofen group. Prednisolone group had even more lid swelling than control group.
c) Chemosis :-These drugs have an impact in reducing the chemosis but definitely it was less in Ibuprofen and oxyphenutazone group then control and prednisolone group.
d) Ciliary Congestion :--The drugs reduced the number of cases of Ciliary congestion in comparison of control cases. It was much less in oxyphenbutazone and Ibuprofen group.
e) Keratitis :-The drugs reduced the cases of keratitis in comparison to control group, it was least in oxyphenbutazone and Ibuprofen group.
f) Hyphema was present in all the groups in lesser or greater extent but it was more in control group than drug groups.
The parameters noted on slit lamp examination were as follows :-
a) Keratitis :-The drug reduced the number of cases of Keratitis in comparison to control group. It was much less in Ibuprofen and oxyphenbutazone group.
b) Hyphema :-Hyphema was present equally in control and prednisolone group but it was absent in Ibuprofen and oxyphenbutazone group.
c) Pigment Dispersion :-Oxyphenbutazone had greater role in complete prevention of pigment dispersion post operatively in comparision to Ibuprofen and prednisolone group while it was present in much more number of cases in control group.
d) Aqueous Flare and K.P.s. :-The drugs had greater role in complete prevention of aqueous fl ir,- and K.P.s. while it was present in cases of control group.
If proper suturing is done, corticosteroids do not prevent wound healing, if given oraly for certain time.
Side effects with anti-inflammatory drugs can be reduced to zero, if patients are properly assessed for their contraindication and supported by antacids orally.
Patients on Ibuprofen and oxoyhenbutazone were hospitalised for less duration than control and prednisolone group, while it was least in oxyphenbutazone group.
To conclude the anti-inflammatory effect of oxyphenbutazone and Ibuprofen was better as compared to cases on prednisolone and control group. The over all assessment favours the superiority of Oxyphenbutazone over other drugs put under trial.