Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 2446
  • Home
  • Print this page
  • Email this page

   Table of Contents      
CASE REPORT
Year : 1984  |  Volume : 32  |  Issue : 2  |  Page : 105-107

Lymphoma of choroid


1 Regional Institute of Ophthalmology, Medical College, Calcutta, India
2 Department of Pathology, B.S. Medical College, Bankura, India

Correspondence Address:
S C Sen
Regional Institute of Ophthalmology, Medical College, Calcutta-700 073
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 6526460

Rights and PermissionsRights and Permissions

How to cite this article:
Sen S C, Pal N C. Lymphoma of choroid. Indian J Ophthalmol 1984;32:105-7

How to cite this URL:
Sen S C, Pal N C. Lymphoma of choroid. Indian J Ophthalmol [serial online] 1984 [cited 2021 Jan 26];32:105-7. Available from: https://www.ijo.in/text.asp?1984/32/2/105/27383

Lymphoma of choroid is a condition of aggregation of lymphocytes in this tissue, which may occasionally appear unassocia­ted with any blood dyscrasia, in the form a tumour which may remain isolated and benign. A primary lymphoma of choroid is an exceptional occurrence. Lymphosarcoma of choroid with invasive nature is more common and often associated with similar tumours elsewhere or it is associated with generalised manifestation of lymphatic diseases[2],[3]. Reese[2] recorded lymphomatous involvement of uvea in 8 cases out of 171 affecting the region of the eye (1 in 21), which included lymphomatous deposits in Iris. McGavic[4] found only one intraocular involvement out of 21 ocular lymphomas. Heath's series of 67 ocular lymphomas, the globe was involved only in three. Primary lymphomatous involve­ment of choroid were reported earlier[6],[7],[8].

Because of very rare incidence, a case of lymphoma of choroid, probably of primary in nature is being reported.


  Case report Top


S.C.D., 67 years male attended Eye O.P.D., with the complain of loss of vision in left eye for about two months.

On examination : Left eye-there was noth­ing abnormal externally except a moderately dilated pupil. Both direct and consensual light reflexes were sluggish. Vision counting fingers at 2 meters, not improving with glasses. There was early Immature Cataract of nuclear type. Tension was 35 mm. (Schiotz). There was no ciliary tenderness nor any sign of uevitis. i here was no proptosis nor any limitation of ocular movements. Ophthalm­oscopial examination revealed detachment of Retina in the lower part, 3 to 4 disc diameters below optic disc and macula, extending from 9 O'clock to 3 O'clock meridians and extend­ing towards lower periphery. No retinal tear or dialysis was detected. There was no abnor­mal pigmentation, no haemorrhage or exu­date in the fundus.

Right eye : Nothing abnormal was observed

Systemic examination did not reveal any abnormality. Our provisional diagnosis was secondary glaucoma in left eye resulting from choroidal growth, probably metastesis from malignant growth elsewhere. In absence of any symptom, ba-meal X-ray of G.I. tract was not done. He was treated Medically for reduc­tion of I.O.P. in left eye.

There was gradual deterioration of vision. Tension in the left eye remained uncolored.

After 9 months Fundus oculus could not be seen due to advanced immature cataract Transillumination test was not informative. Patient complained of occassional pain in the left eye, which was relieved with Tab. Diamox. He ignored medical advice.

Enucleation of the left eye was done under local anaesthesia after one year. After enucleation the bisected eye ball showed no visible growth inside the eye ball. Lens was cataractous, vitreous was fluid, but clear and cornea was hazy.

Post operative period was uneventful. There was no evidence of orbital metastasis.

Laboratory investigations showed Blood Hb-12.76 GM. W.B.C.-4,600 per c.mm. Neutrophil-60%, Lymphocyte-32, Monocyte­2%, Eosinophil-6%, Platelets-adequate. E.S.R.-Ist hr. 52 mm. and 2nd hour-90 mm. Urine-Nothing abnormal, Blood Sugar-l 10 mg.%, X-ray chest-Lung emphysematous with left lateral scoliosis of Dorsolumbar spine. Bone marrow exam:- "It was hypercellular with erythropoid hyperplasia. Erythropoiesis is partially megaloblastic. Myeloid series of cells show shift to left. Plasma cells and lymphocytes were of increased number.


  Histopathological report Top


Microscopically the features of a well dif­ferentiated lymphocytic lymphoma in choroid was revealed. The cells were mono­morphic in appearance and differentiated. The nuclear pattern of the tumour cells showed absence of any variation or giant cell formation. The choroid was diffusely and densely infiltrated by tumour cells in asso­ciation with focal aggregation at places with tendency to form follicular. pattern without definite germinal centre. [Figure - 1][Figure - 2]. Chor­oidal tissue was replaced to a great extent and it was thickened due to dense and diffuse infiltration with lymphocytes. Retina was detached. Other structures of the eye including sclera were free from. infiltration by the tumour cells.


  Discussion Top


Clinically the case appeared to be one of detachment of retina with secondary glau­coma, probably due to metastatic growth in choroid. As there was no pigmentation of retina over the detachment area, we did not think of melanoma of choroid. On general examination, no systemic abnormality could be detected except emphysematous lungs with scoliosis and a few patches of depigmen­tation on face and trunk.

Well differentiated lymphocytic lympho­mas in their initial stages are localised and circumscribed. Such lymphocytic infiltration of choroid closely simulate reactive lymphoid hyperplasia due to chronic inflammation resulting massive thickening by cellular in­filtration wherein lymphocytes are accom­panied by plasma cells. In this case, dense and diffuse infiltration with well differentiated lymphocytes resulting thickening and repl­acement of choroid with tendency to form follicle and absence of plasma cells led us to diagnose the case as lymphoma of choroid. As there was no evidence of systemic lymphatic disease, the lymphoma of choroid seems to be primary. "An isolated lymphoma may be the precursor of a generalised lymphomatous dis­semination". This may progress into a gen­eralised process if the patient survives long enough".

According to Cooks[7] lymphoma of cho­roid may present clinically in four ways-1). Generalised uveitis; 2) Recurrent haemorr­hages in choroid; 3) Retinal detachment and 4) Secondary glaucoma.

In this case there was no evidence of uveitis and choroidal haemorrhage, but the patient presented with retinal detachment and secon­dary glaucoma.

Cause of glaucoma in this case is difficult of explain, as involvement of angle of anterior chamber could not be detected, Intraocular haemorrhage or inflammation was also not operative, Obstructions of venous retina by involving venae vorticose and by increased permeability may be responsible for produc­tion of secondary glaucoma in this case.


  Summary Top


A rare case of choroidal lymphoma, pre­senting initially as a case of detachment of retina with secondary glaucoma has been pre­sented. The relevant literature has been com­pendiously reviewed.


  Acknowledgement Top


We are grateful to the Surgeon-Superint­endent, S.S.KM. Hospital Calcutta for his kind permission to publish this case.

 
  References Top

1.
Duke-Elder, S. and Parkins, E.S. 1966, Systemic Ophthalmology, Vol. IX Henry Kimpton, London, pp 813.  Back to cited text no. 1
    
2.
Reese, A.B. 1963, Tumours of the Eye, 2nd Ed., Harper & Row. New York, pp 469.  Back to cited text no. 2
    
3.
Marcus, H.C., 1963, Arch. Ophthalmol., 69:251.  Back to cited text no. 3
    
4.
McGavic, J.S., 1943, Arch. OphthalmoL, 30, 179193.  Back to cited text no. 4
    
5.
Heath, P.. 1949, Amer. J. Ophthalmol, 32:1213.  Back to cited text no. 5
    
6.
Cooper, E.L. and Ricker, J.L., 1951, Amer. J.Ophthalmol., 34:1153.  Back to cited text no. 6
    
7.
Cook. C., 1954, Br. J. Ophthalmol.. 38:182.  Back to cited text no. 7
    
8.
Givner, L, 1955, Amer. J. Ophthalmol., 39:29.  Back to cited text no. 8
    


    Figures

  [Figure - 1], [Figure - 2]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Case report
Histopathologica...
Discussion
Summary
Acknowledgement
References
Article Figures

 Article Access Statistics
    Viewed2076    
    Printed38    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal