|Year : 1984 | Volume
| Issue : 2 | Page : 97-98
SS Sane1, N Khan2, NS Ingole2
1 Department of Ophthalmology, Mahatma Gandhi Institute of Medical Sciences, Sevagram- Wardha, India
2 Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram- Wardha, India
S S Sane
Deparment of Ophthalmology & Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram-Wardha
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Sane S S, Khan N, Ingole N S. Conjunctival dysplasia. Indian J Ophthalmol 1984;32:97-8
Hyperplasia of conjunctival epithelium with dysplastic changes are rare. Very rarely conjunctiva is so much hypertrophied that it resemble malignant growth.
| Case report|| |
A 24 years Hindu male was admitted with complaints of progressive swelling in left eye since 3 months and inability to open left eye. To start with swelling was in the form of a .nodule in the bulbar conjunctiva near lateral canthus, which gradually ballooned out to surround whole of cornea. No history suggestive of Tuberculosis, Leprosy, Trauma or similar swelling in the past.
Patient of average built, no anaemia, no jaundice. No lymphadenopathy. The growth was occupying whole of the anterior segment of eye and ballooning out about 1 cm out side the palpebral aperture surface was smooth, firm and no tender. There was no bleeding points from surface and it was reddish pink in colour. There was no involvement of lids, but movements of lids resisted because of growth. There was marked chemosis of conjunctiva and restriction of ocular movements.
Rest of anterior segment were normal [Figure - 1]. Acuity of vision of RE 6/6 but in L/E it could not be recorded. Investigations including X-ray orbit (P.A. lateral view) and peripheral blood smear showed no abnormality.
A biopsy specimen of the growth was taken which showed hyperplasia of conjunctival tissue with dysplastic changes and chronic inflammatory reaction [Figure - 2].
The patient was kept on systemic and local corticosteroids. The swelling subsided and the vision was 6/6 when the patient was discharged [Figure - 3].
| Discussion|| |
This type of hyperplasia can be due to irritation, ulceration, injury, (Foreign body, corn, stalk, vegetable matter chalazion, bursting in eye, artificial eye). It may be sessile or polypoid. It may be very much vascularised causing bloody tear and become ulcerated to look like malignant growth.
In this condition the cells are thick and hypercellular. Abnormal cells are abnormally present in cell arrangement. Similar to but less numerous than carcinoma in situ. The most important differences are the pathological changes do not extend through whole thickness of epithelium. Epithelial dysphasia exhibits a spectrum of cellular abnormalities ranging from mild to severe. Mild dysplasia is not a severe dysplasia and is probably reversible severe dysplasia begins to approximate, for carcinoma in situ and will sometime progress to carcinoma if left untreated.
| Summary|| |
Avery rare case of conjunctival dysplasia resembling malignant growth clinically has been described, which responded well to treatment. A growth resembling malignancy, should always be examined histopathologically before drastic operations are undertaken.
| References|| |
Duke Elder, 1965, System of Ophthalmology: Henry Klimpton Publications, London: Inflammatory Hyperplasias, 8,11: 1180.
Greer C.H., 1972, Ocular Pathology: Blackwell Scientific Publications, London, "Conjunctival epithelial dysplasia., II: 99.
Zimmerman, 1962, Ophthalmic Pathology: W.B. Saunders Company. London. Inflammatory of conjunctiva. II: 275.
[Figure - 1], [Figure - 2], [Figure - 3]