• Users Online: 3310
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 1984  |  Volume : 32  |  Issue : 3  |  Page : 181-183

Primary extramedullary solitary plasmacytoma of conjunctiva - a case report

Department of Pathology, Ophthalmology & Radiology. & Radiotherapy, Sardar-Patel Medical College. Bikarner, India

Correspondence Address:
MCR Vyas
Department of Pathology, Sardar Patel Medical College, Bikaner
Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 6519736

Rights and PermissionsRights and Permissions

How to cite this article:
Vyas M, Vyas S P, Chaudhary R K. Primary extramedullary solitary plasmacytoma of conjunctiva - a case report. Indian J Ophthalmol 1984;32:181-3

How to cite this URL:
Vyas M, Vyas S P, Chaudhary R K. Primary extramedullary solitary plasmacytoma of conjunctiva - a case report. Indian J Ophthalmol [serial online] 1984 [cited 2023 Dec 10];32:181-3. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?1984/32/3/181/27417

The primary ocular (conjunctiva) plasmo cytomas are rare.[1],[2],[3] In view of this rarity, a case of solitary primary extramedullary plas­macytoma involving conjunctiva is reported.

  Case report Top

KR. a 22 years old female was first admitted in Government Hospital, Ratangarh (Rajasthan) with the complaints of a pro­gressively increasing painless swelling in the left lower fornix of the eye and slightly incom­plete closure of eye of one year duration. There was no history of any ocular infection, trauma or foreign-body in affected eye in past approxi­mately six months.

On examination there was a grayish pink soft smooth non lobulated, nonreducible and nonfixed painless swelling of approximately 2X0.75X0.5' cms size occupying the lower for nix of the left eye, the upper bulge of the smooth swelling was just visible with open eye. There was no congestion of palpebral and bulbar conjunctiva. The upper eye lid and the right eye were normal and free of tumour.

Cornea was normal without any vas­cularization or opacity. Fundus examination was normal. The examination of ear, nose and throat revealed no abnormality. There was no palpable cervical or axillary lymphadenopathy.

A clinical diagnosis of a benign tumour and conjunctival amyloidosis was made and a local excision was done.

Gross specimen was a tan soft apparently encapsulated mass of 2X 1X0.5 cms size. His­tology of the tumour mass showed a thin fib­rous capsule. It was-cellular with virtually no connective tissue stroma. the cells resembled

The patients haemoglobin level was 12.8 gm%, the ESR 25 mm in the first hour. A bone marrow aspirate showed normal cellularity with no myeloma cells and normal number of plasma cells, a complete skeletal survey failed to show bony masses or osteolytic deposits. No albuminuria or Bence Jones proteinuria was demonstrated, the latter being excluded by serum and urine (concentrated) elec­trophoresis. The serum total protein was 6.3 gms/100 ml. There were no hone tenderness and her body weight unchanged.

Patient received a course of radiotherapy (2500 rads in 10 sittings) and was asked to report for checkup once in a month. In 10 months under follow up no recurrence has occurred.

  Discussion Top

Plasma cell tumours have been divided by Wills[6] into three types viz., plasma cell myelomatosis, solitary plasmacytoma of bone and primary plasmocytoma of soft tissue.

Histological diagnosis of solitary plas­mocytoma at sites like conjunctiva warrants a critical appraisal of the lesion and the diagnosis is made when only monomorphic neoplastic plasma cells seen in sheets groups and clusters without any admixture of the inflammatory cells and other features of inflammatory granuloma.

More et a1[7] and Soja et alb makes the point that the mere presence of large number of plasma cells should not lead to the diagnosis of plasma cell neoplasms but indicates that granuloma may become large enough to be mistaken for the neoplasm. In such cases an infiltrate consisting predominantly of plasma cells found with an admixture of lymphocytes or polymorphs occasionally macrophages and even fibroblasts. Vascular proliferation is common and mitotic figures may also be seen. Our present case rigidly fulfilled the histologi­cal criteria for plasmo cytoma and was com­pletely free from inflammatory pathology. It also provided a supplementary evidence of paramyloid like material in the wall of medium sized vessels.

The presence of generalized disease was adequately excluded by urine examination for Bence Jones proteins, serum protein estimation, skeletal survey, bone marrow studies and serum protein electrophores-is which excluded generalized disease.

The age at presentation range from 8 years plasma cells with hyperchromatic often acentric nuclei and eosinophilic cytoplasm [Figure - 1][Figure - 2]. There was a moderate degree of nuclear pleomorphism, cells with two nuclei were pre­sent. Methyl green pyronin staining showed pyroninophilia of the cytoplasm. Capsular and vascular invasion by tumour cell was not seen. In the tumour substance a few medium sized blood vessels were seen with thickened wall partially replaced by a homogenous eosino­philic hyaline like material. This material was not present elsewhere in tumour. (Amyloid stains provided inconsistent staining -characters). to 52 years, the peak incidence being 5th and 6th decade Wiltshaw.[5] Extramedullary plas­mocytoma vary considerable in size ranging from 1 cm to several cms in diameters, these are normally well defined firm and spherical may be polypoidal.

Treatment of extramedullary plas­mocytoma may be surgery, radiotherapy on chemotherapy, radiotherapy is sometimes given after surgical excision. The behaviour of extra medullary plasmacytoma is unpredic­table. They may follow a benign course with apparent cure after treatment[2],[5]. They may recur spread to regional lymph nodes or dis­seminate involving bone in 40% of cases.[5] Role of radiotherapy for solitary plas­macytoma at various locations has been stressed by Tood[11].

Generally however, more pleomorphic tumours behave more aggressively. Our pre­sent case without conspicuous cellular pleomorphism, mitotic activity and capsular or vascular invasion and also absence of lymphadenopathy has been free of tumour after ten months of surgical removal and radiotherapy. With this we believed that the benign course followed by our patient so far should be maintained.

Atypical amyloid (paramyloid) with atypi­cal histochemical properties may be observed as a consequence of a primary disorder of plasma cell proliferation in situations as blood vessels, skin muscle and gastrointes­tinal tract[10] present case also showed paramyloid deposits in vessel walls.

  References Top

Ashley. D.J.B.: Even's histological appearances of tumour, 1978. 3rd Edn. P. 217, Churchill Livingatons England.  Back to cited text no. 1
Dolin, S. and Dever, J.P. 1956. amer. J. Pathol., 32:83. Am.J. Pathol. 32:83, 1956.  Back to cited text no. 2
Innes, J. and Newall, J. 1961. Lancet, 1, 239, 1968.  Back to cited text no. 3
Hellwig, G.A., 1943, Arch. Pathol. 36:95.  Back to cited text no. 4
Wiltshaw; E. 1971. Brit Med. 12:327.  Back to cited text no. 5
Willis. R.A., 1967, Pathology of tumours, 4th Edn., Page 795. Buttetworth, London, P. 795.  Back to cited text no. 6
More, J.RS., Dawson, D.W., Ralston, A.J. and Craig, I. 1968. J. Clin. Pathol. 21. 661.  Back to cited text no. 7
Soja. J. Sailo, K Suzhki. N. and Sakai, T. 1970 25,618.  Back to cited text no. 8
WEBB. H.E., Harrison, E.G.; Mason, J.K. and RE Mine. W.G. 1962-16:1142.  Back to cited text no. 9
Osserman. E.F.: 1959. New Eng. J. Med. 261;952, 1006.  Back to cited text no. 10
Tood, I.D.H. 1965, Clin. Radiol. 16:395.  Back to cited text no. 11


  [Figure - 1], [Figure - 2]

This article has been cited by
1 Conjunctival plasmacytoma
Yumori, J.W., Ilsen, P., Bright, D.C.
Optometry. 2010; 81(5): 234-239
2 Solitary extramedullary plasmocytoma of the conjunctiva | [Isoliertes extraossäres Plasmozytom der Konjunktiva]
Schulze, B., Kuchenbecker, J., Fleige, B., Krempien, R., Ludwig, W.D., Schröter, H.
Ophthalmologe. 2009; 106(2): 149-151
3 A case of plasmacytoma of the conjunctiva
Ikegami, M., Imai, Y., Kameya, S., Yamaki, K., Yoshitomi, T., Nanjo, H.
Folia Ophthalmologica Japonica. 2006; 57(2): 124-127


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Case report
Article Figures

 Article Access Statistics
    PDF Downloaded2    
    Comments [Add]    
    Cited by others 3    

Recommend this journal