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   Table of Contents      
Year : 1985  |  Volume : 33  |  Issue : 1  |  Page : 57-58

Polymethyl methacrylate (PMMA) intolerance

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, India

Correspondence Address:
V K Dada
Dr. R.P. Centre for Ophthalmic Sciences, A.I.I.M.S., New Delhi-110 029.
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Source of Support: None, Conflict of Interest: None

PMID: 4077208

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How to cite this article:
Dada V K, Kalra V K, Angra S K. Polymethyl methacrylate (PMMA) intolerance. Indian J Ophthalmol 1985;33:57-8

How to cite this URL:
Dada V K, Kalra V K, Angra S K. Polymethyl methacrylate (PMMA) intolerance. Indian J Ophthalmol [serial online] 1985 [cited 2021 Mar 7];33:57-8. Available from: https://www.ijo.in/text.asp?1985/33/1/57/27335

The allergic reaction to Polymethyl Methacrylate is extremely rare[1],[2]. This report highlights a rare allergic manifestation of Polymethyl methacrylate in a well fitted patient of keratoconus who had used contact lenses for the last 20 years.

  Case report Top

A 48 year old lady presented with the complaints of watering, itching & photo­phobia with contact lenses for last two months. The symptomatology gradually increased with time. Patient did not give any history of urticarial rash, chronic sinusitis, asthma or eczema. She was not using mascara, perfumes or any local medication. There was no change in contact lens solution and the condition persisted even when the hard contact lens solution was not used at all. The lenses were fitting well on the cornea.

On examination, she showed dry eczema­tous lesions of the lids which were excoriated in the inner one third due to frequent rub­bing. Cornea was keratonotic and was moderately advanced. Posterior segment and intraocular pressure were normal.

Lenses were withdrawn and there was dramatic recovery of lid and conjunctival inflammation.
"Patch Test" was done with various contact lens materials like PMMA, CAB (Cellulose Acetate Butyrate) and HEMA (Hydroxy ethyl methacrylate). The test was positive for PMMA and negative for the others. Replacement with CAB lenses did not show any reaction and the patient is tolerating them well without any allergic symptoms.

  Discussion Top

Allergic inflammatory background can hinder successful outcome of any medical or surgical procedure. Same can hold true for contact lenses. To rule out allergic back­ground for the future success every client should be screened through a set of question­naire for eliciting the exact background and for future guidance. This should include personal & family history of any allergic disorder in the form of asthma, hay fever, eczema, dermatitis, rhinitis, spring catarrh etc. Besides this patch test on the skin with various contact lens materials may help us to find such reactions.

The allergic reaction in this patient after 20 years of successful use can probably be explained by the absorption of biodegraded

PMMA material with hapten of tear proteins to act as allergen.

  Summary Top

A rare case of P.M.M.A. allergy in a well fitted case of keratoconus is described. Allergic symptoms subsided after changing the material. Patch test was positive with P.M.M.A. Genesis of allergic reaction is discussed.

  References Top

Lowther E.L. and Bier N., 1977, Contact lens correction. Butterworths, London, Page 103.  Back to cited text no. 1
Stone, J. and Phillips AJ., 1980, Contact lenses, Butterworths. London page 170.  Back to cited text no. 2


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