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Year : 1987  |  Volume : 35  |  Issue : 4  |  Page : 197-203

Oral Ketoconazole in Keratomycosis


Correspondence Address:
Philip A Thomas

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Source of Support: None, Conflict of Interest: None

PMID: 3506929

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We treated 30 patients with Keratomycosis (11 with Aspergillus infections, 6 with Fusarium infections, 3 with Curvularia infections and 10 with infections caused by other fungi) with Ketoconazole administered orally. Progressive comeal ulceration stopped in 20 cases clinical evidence of corneal infection disappeared and post treatment visual acuities were better than pre-treatment visual acuities. 10 cases did not respond to therapy and developed progressive corneal ulceration, necessitating other measures The presence of deep lesions in all these 10 cases and the recovery of Aspergillus flaws or Fusarium from 9 of these cases appeared to influence non-responsiveness to therapy. There was no evidence of serious systemic or ocular toxicity in any of the patients.

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