Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 237
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 1990  |  Volume : 38  |  Issue : 1  |  Page : 17-19

Role of 5 fluorouracil in the management of failed glaucoma surgery


R.P. Centre for Ophthalmic Sciences, New Delhi-29, India

Correspondence Address:
N N Sood
R.P. Centre for Ophthalmic Sciences, New Delhi-29
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 2365431

Rights and PermissionsRights and Permissions

Filtering surgery for glaucoma usually controls the intraocular pressure adequately. However, in glaucoma patients with aphakia, neovascularisation of iris, previous failed filtering surgeries and relatively young patients, results of surgery leave much scope for improvement. Most failures of filtering surgery are related to extra-ocular factors. Histopathological studies of eyes after failed filtering operations have suggested that proliferation of fibroblasts and deposition of collagen constitute a barrier to filteration. There is also a positive correlation between success of filtering surgery and inhibition of fibroblast growth by the patients aqueous humour. Thus agents inhibiting fibroblast proliferation should play an important role in increasing the success rate of filtering surgery. 5 Fluorouracil is a pyrimidine analogue which has been utilised for over 15 years as an antimetabolite in cancer therapy. Its efficiency in inhibiting fibroblast proliferation in vitro and in rabbit eyes has been proved beyond doubt. We undertook a pilot project to estimate the efficiency of the subconjunctival 5 FU to increase the changes of success in problematic cases of glaucoma in pigmented eyes.


[FULL TEXT] [PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4507    
    Printed102    
    Emailed2    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal