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ORIGINAL ARTICLE
Year : 1991  |  Volume : 39  |  Issue : 4  |  Page : 148-150

Clinico-biochemical study of experimental complicated cataracts


Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All Institute of Medical Sciences, New Delhi 110 029, India

Correspondence Address:
R Sihota
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All Institute of Medical Sciences, New Delhi 110 029
India
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Source of Support: None, Conflict of Interest: None


PMID: 1810872

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Clinically observed complicated cataracts, generally do not have a definite causal factor. We studied the effects of E. coli toxin injected suprachoroidally, to simulate the effect of toxins released by extraocular organisms on the lens. 79.2% of eyes had a definable cataract at the end of the 6th week of observation. The biochemical changes portrayed an increased oxidative activity in the lens, evidenced by a fall in glutathione concentration, and the consequent tertiary reorientation of proteins to increase insoluble proteins, forming a cataract.


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