| ORIGINAL ARTICLE |
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| Year : 1991 | Volume
: 39
| Issue : 4 | Page : 148-150 |
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Clinico-biochemical study of experimental complicated cataracts
R Sihota, Madan Mohan, SK Angra, RL Mathur
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All Institute of Medical Sciences, New Delhi 110 029, India
Correspondence Address:
R Sihota
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All Institute of Medical Sciences, New Delhi 110 029
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 1810872 
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Clinically observed complicated cataracts, generally do not have a definite causal factor. We studied the effects of E. coli toxin injected suprachoroidally, to simulate the effect of toxins released by extraocular organisms on the lens. 79.2% of eyes had a definable cataract at the end of the 6th week of observation. The biochemical changes portrayed an increased oxidative activity in the lens, evidenced by a fall in glutathione concentration, and the consequent tertiary reorientation of proteins to increase insoluble proteins, forming a cataract. |
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