| ORIGINAL ARTICLE |
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| Year : 1991 | Volume
: 39
| Issue : 4 | Page : 174-175 |
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Anti-insulin antibodies and retinopathy in juvenile onset type-1 diabetes
K Sharma, PK Khosla, HK Tiwari, RK Sharma, JS Bajaj
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, Department of Medicine, Department of Anatomy, All Institute of Medical Sciences, New Delhi, India
Correspondence Address:
K Sharma
Department of Neuro-Ophthalmology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Post Box 375, Lucknow - 226001
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 1810880 
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Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabetic complications like microangiopathy is not very clear. In the present study, there was statistically a significant trend of higher insulin antibody binding levels in IDDM patients who developed retinopathy. Though there was a trend of higher insulin antibody in IDDM patients with retinopathy, there was no association between insulin antibody and HLA antigen which some authors have reported. |
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| [FULL TEXT] [PDF Not available]* |
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