| ORIGINAL ARTICLE |
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| Year : 1993 | Volume
: 41
| Issue : 4 | Page : 185-186 |
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Incidence of complications following 5-fluorouracil with trabeculectomies
Ravi Thomas, Aby Jacob, Renu Raju, Stephen C Gieser, Subir Sen
Department of Ophthalmology, Christian Medical College, Vellore, India
Correspondence Address:
Ravi Thomas
Schell Eye Hospital, Vellore, Tamil Nadu 632 001
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 8005651 
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To investigate the incidence of complications reportedly caused by the use of 5-fluorouracil (5-FU) in glaucoma filtering surgery, we performed trabeculectomy with 5-FU on 57 eyes of 56 patients with advanced glaucoma. The mean preoperative intraocular pressure was 34.8 mm Hg. The most frequent complication encountered was superficial punctate keratopathy (26%), followed by shallowing of the anterior chamber (12%), choroidal detachment (9%), and flap retraction (7%). We, however, did not encounter any cases of confluent corneal epithelial defect, subepithelial scarring, or striate melanokeratosis which are usually described with the use of 5-FU. With a mean follow-up of 7.1 months, an intraocular pressure less than 16 mm Hg without hypotensive therapy were achieved in 73.7% of cases, and less than 21 mm Hg without hypotensive therapy in 86%. Considering the low incidence of complications and the high success rate, we recommend the use of 5-FU in routine glaucoma filtering surgery |
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