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Year : 1996  |  Volume : 44  |  Issue : 2  |  Page : 91-94

Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy - pilot prial

Medical Research Foundation, 18 College Road, Madras 600 006, India

Correspondence Address:
Binita Shelat
Medical Research Foundation, 18 College Road, Madras 600 006
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Source of Support: None, Conflict of Interest: None

PMID: 8916596

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To study the effect of 5-Fluorouracil (5-FU) in glaucoma filtration surgery, 13 eyes of 12 patients with glaucoma were subjected to trabeculectomy with intraoperative one minute exposure of 50 mg/ml 5-FU. The average age of patients was 36.42 18.78 years. Two of the patients had developed hypotony in the fellow eye following the use of Mitomycin C with trabeculectomy. The mean follow-up period was 9.54 5.17 weeks. Two patients developed a shallow anterior chamber with choroidals postoperatively which responded to conservative treatment. One patient developed an encysted bleb one month after surgery. Single one minute intraoperative exposure to 5-FU is a convenient and inexpensive method which appears to have no significant side effects. It may be a useful adjunctive treatment to optimise the results of glaucoma filtration surgery particularly in young and myopic patients. The long term effects, however, are not known.

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