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ORIGINAL ARTICLE
Year : 1998  |  Volume : 46  |  Issue : 3  |  Page : 159-162

Human lens epithelial layer in cortical cataract


Department of Zoology, School of Sciences, Gujarat University, Ahmedabad, India

Correspondence Address:
N Kalariya
Department of Zoology, School of Sciences, Gujarat University, Ahmedabad
India
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Source of Support: None, Conflict of Interest: None


PMID: 10085629

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Normal and cataractous human eye lenses were studied by morphology and protein analysis. A marked decrease in protein sulfhydryl (PSH) and nonprotein sulfhydryl (NSPH) was observed in nuclear and cortical cataractous epithelia. Moreover, decrease in PSH contents and an increase in insoluble proteins were found to be correlated only in cortical cataractous epithelium which is also accompanied by various morphological abnormalities. In nuclear cataractous epithelium, however, there was very little insolubilisation of proteins. The epithelial morphology in nuclear cataracts was almost similar to normal lens epithelium. Hence, it is assumed that the protein insolubilisation and various morphological abnormalities are characteristics of cortical cataractous epithelium. This leads us to believe that opacification in cortical cataract might initiate in the epithelial layer.


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