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Year : 1999  |  Volume : 47  |  Issue : 1  |  Page : 25-29

Influence of UV-irradiation on enzymes in mouse ocular lens: in vitro studies

Department of Zoology, School of Sciences, Gujarat University, Ahmedabad, India

Correspondence Address:
Nayan K Jain
Dept. of Zoology, School of Sciences, Gujarat University, Ahmedabad
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Source of Support: None, Conflict of Interest: None

PMID: 16130281

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Purpose: In vitro study of the enzymes involved in aerobic, anaerobic and hexose monophosphate shunt in ultraviolet radiation exposed mice lenses. Method: Of the selected enzymes, lactic dehydrogenase (LDH) was representative of anaerobic glucose oxidation, succinic dehydrogenase (SDH) of the aerobic oxidation, and Glucose-6-phosphate dehydrogenase (G-6-PDH) of the Hexose Monophosphate (HMP) shunt. Other enzymes studied were ATPase and glutathione reductase (GR). Results: Experiments with mice lenses in vitro showed that transparent lens became opaque following UV-irradiation at 360 nm. Opacification of the lens was accompanied by a change in enzyme activities for energy metabolism. Conclusion: These changes were progressive in a manner analogous to sequential morphological changes, which would be crucial in maintaining lens transparency.

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