| ORIGINAL ARTICLE |
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| Year : 2000 | Volume
: 48
| Issue : 4 | Page : 307-9 |
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Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.
P Srivastava, S Saxena, VK Khanna, D Kumar, R Nath, PK Seth
King George's Medical College, Lucknow, India
Correspondence Address:
P Srivastava
King George's Medical College, Lucknow
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 11340890 
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BACKGROUND: Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease. METHODS: TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17). RESULTS: Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01). CONCLUSION: The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation. |
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