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Year : 2001  |  Volume : 49  |  Issue : 3  |  Page : 153-168

New perspectives in ocular surface disorders. An integrated approach for diagnosis and management

1 Cornea Service, L.V. Prasad Eye Institute, L.V. Prasad Marg, Banjara Hills, Hyderabad - 500 034, India
2 Cornea service, L.V. Prasad Eye Institute, Hyderabad, India (VSS), and Ocular Surface & Tear Center, Dept. of Ophthalmology, Bascom Palmer Eye Institute, and Dept. of Cell Biology & Anatomy, University of Miami School of Medicine, Miami, Florida, USA

Correspondence Address:
Virender S Sangwan
Cornea Service, L.V. Prasad Eye Institute, L.V. Prasad Marg, Banjara Hills, Hyderabad - 500 034
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Source of Support: None, Conflict of Interest: None

PMID: 15887723

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The cornea, conjuctiva and the limbus comprise the tissues at the ocular surface. All of them are covered by stratified, squamous, non-keratinizing epithelium and a stable tear film. The ocular surface health is ensured by intimate relationship between ocular surface epithelia and the preocular team film. There are two types of ocular surface failure. The first one is characterized by squamous metaplasia and loss of goblet cells and mucin expression. This is consistent with unstable tear film which is the hallmark of various dry-eye disorders. The second type of ocular surface failure is characterized by the replacement of the normal corneal epithelium in a process called limbal stem cell deficiency. It is essential to establish accurate diagnosis for appropriate management of complex ocular surface disorders. There has been considerable advancement in the understanding of the pathophysiology of ocular surface disease. Management has improved with introduction of the limbal stem cell concept and use of amniotic membrane transplantation.

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