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ORIGINAL ARTICLE
Year : 2005  |  Volume : 53  |  Issue : 1  |  Page : 17-22

Epidemiological and Microbiological Diagnosis of Suppurative Keratitis in Gangetic West Bengal, Eastern India


1 Disha Eye Hospital & Research Centre, Barrackpore, West Bengal, India
2 and School of Tropical Medicine, Kolkata, India

Date of Submission17-May-2004
Date of Decision24-Nov-2004

Correspondence Address:
Samar K Basak
Disha Eye Hospitals & Research Centre, Barrackpore, North 24-Parganas, West Bengal - 700 120
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.15280

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  Abstract 

PURPOSE: To determine the epidemiologcial pattern and risk factors involved in suppurative corneal ulceration in Gangetic West Bengal, eastern India, and to identify the specific microbial agents responsible for corneal infections. METHODS: All patients with suspected microbial keratitis presenting to the corneal clinic at Disha Eye Hospital, Barrackpore, West Bengal, India, from January 2001 to December 2003 were evaluated. Sociodemographic data and information pertaining to the risk factors were recorded. After diagnosing infective corneal ulcer clinically, corneal scraping and cultures were performed. RESULTS: Over a three-year period, 1198 patients with suppurative keratitis were evaluated. Ocular trauma was the most common predisposing factor in 994 (82.9%) patients (P< 0.0001), followed by use of topical corticosteroids in 231 (19.28%) patients. Cultures were positive in 811 (67.7%) patients. Among these culture positive cases, 509 (62.7%) patients had pure fungal infections (P< 0.001), 184 (22.7%) patients had pure bacterial infections and 114 (14.1%) had mixed fungal with bacterial infections. Acanthamoeba was detected in 4 (0.49%) patients. The most common fungal pathogen was Aspergillus spp representing 373 (59.8%) of all positive fungal cultures (P< 0.0001), followed by Fusarium spp in 132 (21.2%) instances. Most common bacterial isolate was Staphylococcus aureus, representing 127 (42.6%) of all the bacterial culture (P< 0.0001) followed by Pseudomonas spp 63 (21.1%). CONCLUSION: Suppurative keratitis in Gangetic West Bengal, most often occurs after a superficial corneal trauma with vegetative or organic materials. Fungal ulcers are more common than bacterial ulcers. Aspergillus spp and Staphylococcus aureus were the most common fungus and bacteria respectively. These ′regional′ findings have important public health implications for the treatment and prevention of suppurative corneal ulceration in this region of India.

Keywords: Suppurative keratitis, epidemiology, Gangetic West Bengal


How to cite this article:
Basak SK, Basak S, Mohanta A, Bhowmick A. Epidemiological and Microbiological Diagnosis of Suppurative Keratitis in Gangetic West Bengal, Eastern India. Indian J Ophthalmol 2005;53:17-22

How to cite this URL:
Basak SK, Basak S, Mohanta A, Bhowmick A. Epidemiological and Microbiological Diagnosis of Suppurative Keratitis in Gangetic West Bengal, Eastern India. Indian J Ophthalmol [serial online] 2005 [cited 2024 Mar 28];53:17-22. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2005/53/1/17/15280



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Corneal infections are the second most common cause of monocular blindness after unoperated cataract in some developing countries in the tropics.[1]-[3] The incidence of microbial keratitis varies from 11 per 100,000 persons/year in the United States to 799 per 100,000 persons/year in Nepal.[4],[5] The associated ocular morbidity is the result of several factors and patients′ management is directly affected by the lack of diagnostic facilities and initiation of appropriate antimicrobial therapy. Specific treatment requires quick and accurate identification of the causative micro-organisms.[6]

The epidemiological pattern and causative agents for suppurative corneal ulcer varies significantly from country to country, and even from region to region within the same country. It is important to determine the "regional" aetiology within a given region for comprehensive strategy for the diagnosis and treatment of corneal ulcer.[6] Several studies have addressed these questions in the Indian subcontinent.[1],[2],[5],[7]-[20] But only one small-size study is available from rural Bengal19 and one study on fungal keratitis from Assam (Medline Search).[20] A comprehensive data as regards to the demographical and aetiological factors of suppurative corneal ulcerations from eastern India is not available.

The purpose of this study was to evaluate all suppurative keratitis seen at a semi-urban large eye hospital in West Bengal, eastern India, over a period of three years from January, 2001 to December, 2003. We also attempted to search for the antecedent risk factors predisposing to the development of suppurative keratitis and to identify the specific microorganisms responsible for infections. We believe this will help in management of such cases in this region.


  Materials and Methods Top


Patients

The data on suppurative keratitis was collected prospectively at Disha Eye Hospitals and Research Centre, Barrackpore, West Bengal in between 1 January, 2001 to 31 December, 2003. Disha Eye Hospitals and Research centre is a tertiary care eye institute in eastern India that caters to the patients from North 24-Parganas district and surrounding four Districts of Gangetic West Bengal, a population of over 10 million.

All patients were included consecutively after the initial clinical diagnosis of suppurative corneal ulcer was made. Corneal ulcer was defined as a loss of the corneal epithelium with underlying stromal infiltration and suppuration associated with signs of inflammation with or without hypopyon.7 The ulcers excluded from this study were: typical or suspected viral ulcers, healing ulcers, Mooren′s ulcer, marginal keratitis, interstitial keratitis, atheromatous ulcer, neurotrophic keratitis, and any ulcer associated with systemic or autoimmune diseases. A standardised form was completed for each patient documenting socio-demographic information as well as clinical findings including duration of symptoms, past treatment, time of presentation, predisposing ocular conditions and associated systemic risk factors amongst other clinical details.

Clinical procedure

The visual acuity was measured in a standard manner. All patients were examined under slitlamp biomicroscope by an ophthalmologist. The size of the ulcer was measured after staining with wet sterile fluorescein paper strip using the variable slit on the slit lamp and recorded in millimeters. In a similar way, size of the stromal infiltrate and depth of the lesion was recorded. Ulcer margin, floor, thinning, satellite lesions, pigmentation on the ulcer surface, any impacted foreign body were noted. The presence of hypopyon was recorded and its height was measured in millimeters. Any associated ocular condition like trichiasis/entropion, blepharitis, Bell′s palsy, lagophthalmos, chronic dacryocystitis, dry eyes, corneal anaesthesia, bullous keratopathy, spheroidal degeneration of the cornea, any surgery on the cornea, use of contact lens, or ocular leprosy was also noted. The use of topical medications including topical corticosteroids were also noted.7,18

Corneal scraping was performed under strict aseptic conditions by an ophthalmologist using a sterile Bard-Parkar blade (No 15).18,21 The procedure was performed under magnification of a slitlamp or binocular loupe following instillation of preservative-free 2% lignocaine hydrochloride. Material obtained from scraping of the leading edge and base of each ulcer was inoculated in the media and smeared onto two slides, one stained with Gram stain and the other with 10% Potassium hydroxide (KOH) for direct microscopic evaluation.6

Laboratory procedures

For bacterial cultures, the materials were inoculated aerobically at 370 C onto blood agar, chocolate agar, and potato dextrose agar (PDA). Cultures on blood agar and chocolate agar was evaluated at 24 hours and 48 hours, and then discarded if there was no growth. For fungal cultures the materials were inoculated on to Sabouraud dextrose agar (SDA) and incubated at room temperature, examined daily, and discarded after 2 weeks if there was no growth. When KOH smears were positive for amoebic cysts, a further corneal scraping was performed and the material was inoculated onto non-nutrient agar overlaid with Escherichia coli; this was discarded if there was no growth after 7 days.6 Bacterial cultures were considered positive only if growth of the same organism was demonstrated on both media or there was semi confluent growth at the site of inoculation on one media with identification of morphological characteristics of similar organism in Gram Stain.6

The specific identification of bacterial pathogens was based on microscopic morphology, staining characteristics and biochemical properties using standard laboratory criteria. Fungi were identified by their colony characteristics on SDA and by the morphological appearance of the spores in lactophenol cotton blue stain, and in some cases by slide culture method. If by microscopy in KOH mount preparation, hyphae were observed in corneal smear, but failed to grow in culture, the causative organism was reported as fungal.6 All laboratory methods followed standard protocols which have been discussed in details in previous publications.1, 6, 7, 18


  Results Top


Epidemiological Characteristics

1198 patients with the clinical diagnosis of corneal ulcer with or without hypopyon were enrolled for this study. 846 (70.6%) patients were males and 352 (29.4%) were females (p< 0.0001). In both groups, keralitis occurred most frequently (591; 49.3%) in the age group 21-40 years (P< 0.0001). Most of the patients (941; 78.5%) were from rural areas (P< 0.0001). The majority (691; 57.6%) were farmers or agricultural workers, usually working in paddy or jute fields. A majority of the patients (621; 51.8%) were seen between 2-3 weeks of their illness at our hospital and 156 (13%) patients reported after 4 weeks. There was a significant increase in patients (297; 24.8%) during the month of November and December ([Table - 1]). Primary care was sought by 1056 (88.1%) patients before their first visit to us. Among them, 538 (50.9%) patients were seen by ophthalmologists, (142; 13.4%) received advice from ophthalmic assistants, (106; 10.0%) went to general physician, (224; 21.2%) received advice from chemists and 29 (2.3%) patients went to physicians of alternative medicine (Homeopathy, Ayurved). Only 7 (0.67%) patients went to village healers. 393 (37.22%) patients consulted two or more physicians before presenting to us.

Of the patients who were on some form of topical medication (n = 1056), 918 (86.9%) were taking antibiotic drops (ciprofloxacin, tobramycin, ofloxacin, chloramphenicol, or sparfloxacin), 194 (18.4%) patients were taking antifungal eye drops, (natamycin or itraconazole), 136 (12.8%) were on acyclovir eye ointment, 231 (21.8%) were taking topical corticosteroids and in 34 (3.2%) patients the name of medication could not be ascertained.

Predisposing factors

A history of recent corneal injury was obtained in 994 (82.9%) patients. 715 (59.6%) patients had corneal injury with vegetative matter; mostly (526; 43.9%) paddy or paddy stalk (P< 0.0001), followed by jute plant (128; 10.6%). Other significant agents were twig of a tree, flying insect, dirt, mud, sand, etc. Ocular problems predisposing to corneal ulcer were present in 121 (10.1%) patients. Among them, 29 (2.4%) patients had chronic dacryocystitits and 18 (1.5%) had dry eyes. In addition, 8 patients were postsurgical and 4 patients were soft contact lens users. 92 (7.6%) were diabetic and 6 patients had leprosy ([Table - 2]). The risks for suppurative keratitis associated with these predisposing conditions were presumptive.[7]

Microbial Diagnosis

Cultures were positive in 811 (67.7%) corneal ulcers. 509 (42.5%) patients had pure fungal growth, 184 (15.3%) had pure bacterial growth, 114 (9.5%) cases had mixed bacterial and fungal growth, and 4 (0.3%) patients were positive for Acanthemoeba. The remaining 387 (32.3%) patients were culture negative ([Table - 3]). 298 bacterial growths were obtained from 184 patients. Of the 298 isolates 214 (71.8%) were gram positive and 84 (28.2%) were gram negative. Staphylococcus aureus was the most commonly isolated bacterial organism (127; 42.6%) of all positive bacterial cultures. The other isolated gram-positive organisms were Staphylococcus epidermidis (15.7%), Streptococci pneumoniae (9.4%), and Diphtheroids. Pseudomonas spp, the most frequently occurring gram-negative organism was isolated from 63 (21.1%) cultures ([Table - 4]). The other gram-negative organisms were Enterobactor spp, Moraxella spp, Haemophilus influenzae, etc. There were 623 fungal isolates in 509 patients - 373 (59.8%) grew Aspergillus spp, 132 (21.2%) grew Fusarium spp and 63 (10.1%) grew Penicillium spp. Yeast form, Candida spp was positive in 7 (1.1%) cases. Dematiacious fungi, such as Curvularia, Alternaria, Bipolaris and Cladosporium were present in 12 (1.7%) cases ([Table - 5]).


  Discussion Top


In this study, the majority of the corneal ulcer patients (70.7%) were agricultural workers and daily wage earners, an occupation profile similar to south Indian study7,[18] (66.8% and 79.3% respectively), but in contrast to Ghana, where only 16.1% of the patients were agricultural workers.[22] Undoubtedly, ocular injury with paddy or its stalk was the most common (43.91%) predisposing factor in this study, followed by jute plant (10.7%), another important crop in Gangetic West Bengal. Any preventive programme obviously should address this occupation related corneal trauma.

Unlike south India (60%),[7] only 132 (11.1%) patients in this study presented during the first week of their illness. Before their first presentation at our hospital, 1056 (88.1%) patients had consulted health-care provider of some kind, and 680 (56.7%) of them had consulted ophthalmic personnel. Similar to the south India, most eye medications are sold over the counter without a prescription in West Bengal and it is not a surprising observation that 224 (18.7%) patients received some form of topical medication from a chemist before their first consultation. It is also a matter of serious concern that 231 (19.3%) patients were on topical corticosteroids for variable duration. This was in contrast to the reports of 8% and 1.1% from south India.[7],[18]

A significant increase (297; 24.8%) in the number of cases of suppurative keratitis was observed during harvesting seasons of November-December (p< 0.001). Others have noted an increase incidence of fungal keratitis during the dry, windy, harvesting seasons compared with the wet, humid months of the year,[6],[9],[10],[23] and few others have reported an increase during the hot and humid months.[15],[22],[24]

In this study 811 (67.7%) of 1198 corneal scrapings were culture positive. This is similar to reports in Ghana6 and south India,[7],[18] 57.3%, 68.4% and 70.6% culture positive respectively. Culture and/or smear- positive fungi were identified as the principal aetiologic agent in 596 (49.7%) patients of all corneal ulcers. Among these, 87 (7.2%) cases were only smear-positive for fungus. 114 (9.5%) patients with mixed infections were considered primarily fungal for therapeutic reasons. So a total of 710 (59.3%) were treated as fungal infection. This figure is higher than the south Indian reports by Srinivasan et al,[7] (51.9%) Leck et al, [6] (44.1%) Bharathi et al.[18] It is also higher than the study from Assam, eastern India where the incidence of fungal keratitis was 32%. Mixed infections both by bacteria and fungi were also more (9.5%) in the current series as compared to the reports by Srinivasan et al (5.1%),[7] Leck et al (5.5%)[6] and Bharathi et al (2.4%)[18] from south India.

298 (24.8%) were bacteria positive, 15.3% had pure bacterial infection and 9.5% had a mixed infection. This reduction in bacterial corneal ulcers in general at the referral centres might be attributed to more successful treatment of bacterial corneal ulcers in the periphery since the introduction of topical fluoroquinolones in the late 1990s.[24] Of the 298 bacterial isolates, 42.6% was Staphylococcus aureus, which was similar to the early study from Bengal.[20] The most common infecting bacteria was Streptococcus pneumoniae in Nepal and south India,[1],[5],[7] and Pseudomonas spp in Ghana and Bangladesh.[6],[9]

The most commonly isolated fungal pathogens in the current series were Aspergillus spp. Of 623 fungal isolates, 59.8% were Aspergillus spp, 21.2% were Fusarium spp and 10.1% were Penicillium spp. In our study, Candida spp [(7; 1.12%) and pigment-producing dematiaceous fungi (12; 1.78%)] were less compared to other studies.[1],[18] Aspergillus species were predominate in Mumbai, parts of south India, north India, Nepal and Bangladesh.[1],[9],[12],[13],[16]-[18] Other studies in south India have reported Fusarium spp to be more common than Aspergillus spp.[6],[8],[21] Fusarium spp have also been found to be the principal fungal pathogen in Florida, Paraguay, Nigeria, Tanzania, Hong Kong and Singapore.[4],[25]-[32] This phenomenon may be explained by differences in climate and the natural environment. Acanthamoeba infections were present in 4 (0.3%) patients. Two of them were contact lens wearers, and the other two patients gave a history of trauma to the eye while takeing bath on pond.

In summary, suppurative keratitis continues to be a cause for concern among the ophthalmologists in West Bengal and it is evident that predominance of agricultural activity in the Gangetic West Bengal is the principle causative factor. This "regional" information is important with regard to empirical management, as many eye clinics in the locality do not have microbiology facilities. It will also help us formulate guidelines for prevention of suppurative keratitis in the population at risk.



 
  References Top

1.
Upadhyay MP, Karmacharya PC, Koirala S, Tuladhar NR, Bryan LE, Smolin G, et al. Epidemiologic characteristics, predisposing factors, and aetiologic diagnosis of corneal ulceration in Nepal. Am J Ophthalmol 1991;111:92-99.  Back to cited text no. 1
    
2.
Gonzales CA, Srinivasan M, Whitcher jP, Smolin G. Incidence of corneal ulceration in Madurai District, south India. Ophthalmic Epidemiol 1996;3:159-66.  Back to cited text no. 2
[PUBMED]    
3.
Whitcher JP, Srinivasan M, Upadhayay MP. Corneal blindness: a global perspective. Bull World Health Organ 2001;79:214-21.  Back to cited text no. 3
    
4.
Erie JC, Nevitt MP, Hodge DO, Ballard DJ. Incidence of ulcerative keratitis in a defined population from 1950 through 1988. Arch Ophthalmol 1993;111:1665-71.  Back to cited text no. 4
[PUBMED]    
5.
Upadhyay MP, Karmacharya PC, Koirala S, Shah DN, Shakya S, Shrestha JK, et al. The Bhaktapur eye study: ocular trauma and antibiotic prophylaxis for prevention of corneal ulceration in Nepal. Br J Ophthalmol 2001;85:388-92.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  
6.
Leck AK, Thomas PA, Hagan M, Kaliamurthy J, Ackuaku E, John M, et al. Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis. Br J Ophthalmol 2002;86:1211-15.  Back to cited text no. 6
    
7.
Srinivasan M, Gonzales CA, George C, Cevallos V, Mascarenhas JM, Asokan B, et al. Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India. Br J Ophthalmol 1997;8:965-71.  Back to cited text no. 7
    
8.
Dunlop AA, Wright ED, Howlader SA, Nazrul I, Hussain R, McCellan K, et al. Suppurative Corneal ulceration in Bangladesh: A study of 142 cases examining the microbial diagnosis, clinical and epidemiological features of bacterial and fungal keratitis. Aust NZ Ophthalmol 1994;22:105-10.  Back to cited text no. 8
    
9.
Williams G, Billson F, Husain R, Howlader SA, Islam N, McCellan K. Microbiological diagnosis of suppurative keratitis in Bangladesh. Br J Ophthalmol 1987;71:315-21.  Back to cited text no. 9
    
10.
Chander J, Sharma A. Prevalence of fungal corneal ulcers in northern India. Infection 1994;22:207-09.  Back to cited text no. 10
    
11.
Mahajan VM. Ulcerative keratitis: an analysis of laboratory data in 674 cases. J Ocul Ther Surg 1985;4:138-41.  Back to cited text no. 11
    
12.
Despande SD, Koppikar GV. A study of mycotic keratitis in Mumbai. Indian J Pathol Microbiol 1999;42:81-87.  Back to cited text no. 12
    
13.
Garg P, Gopinathan U, Choudhary K, Rao GN. Keratomycosis: clinical and microbiological experience with dematiaceous fungus. Ophthalmology 2000;107:574-80.  Back to cited text no. 13
[PUBMED]  [FULLTEXT]  
14.
Kunimoto DY, Sharma S, Garg P, Gopinathan U, Miller D, Rao GN. Corneal ulceration in the elderly in Hyderabad, south India. Br J Ophthalmol 2000;84:54-59.  Back to cited text no. 14
    
15.
Kotigadde S, Ballal M, Jyothirlatha, Kumar A, Srinivas R, Shivananda PG. Mycotic keratitis: a study in coastal Karnataka. Indian J Ophthalmol 1992;40:31-33.  Back to cited text no. 15
[PUBMED]  Medknow Journal  
16.
Sundaram BM, Badrinath S, Subramanian S. Studies on mycotic keratitis. Mycoses 1989;32:568-72.  Back to cited text no. 16
[PUBMED]    
17.
Venugopal PL, Venugopal TL, Gomathi A, Ramkrishna ES, Ilavarasi S. Mycotic keratitis in Madras. Indian J Pathol Microbiol 1989;32:190-97.  Back to cited text no. 17
    
18.
Bharathi MJ, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R. Epidemiological Characteristics and laboratory diagnosis of fungal keratitis: a three-year study. Indian J Ophthalmol 2003;51:315-21.  Back to cited text no. 18
[PUBMED]  Medknow Journal  
19.
Das SK. Hypopyon corneal ulcers in rural Bengal. JIMA 1972;58:93-95.  Back to cited text no. 19
    
20.
Dutta LC, Dutta D, Mohanty P, Sharma J. Study of fungal keratitis. Indian J Ophthalmol 1981;29:407-09.  Back to cited text no. 20
[PUBMED]  Medknow Journal  
21.
Sharma S, Athmanathan T. Diagnostic procedures in infectious keratitis. In: Nema HV, Nema N, editors, Diagnostic procedures in Ophthalmology. Jaypee Brothers Medical Publishers, New Delhi; 2002. pp 232-53.  Back to cited text no. 21
    
22.
Hagan M, Wright E, Newman M, Dolin P, Johnson G. Causes of suppurative keratitis in Ghana. Br J Ophthalmol 1995;79:1024-28.  Back to cited text no. 22
    
23.
Thylefors B. Epidemiological patterns of ocular trauma. Aust NZ J Ophthalmol 1992;20:95-98.  Back to cited text no. 23
    
24.
Jeng BH, McLeod SD. Microbial keratitis (Editorial). Br J Ophthalmol 2003;87:805-06.  Back to cited text no. 24
    
25.
Liesegang TJ, Forstor RK. Spectrum of microbial keratitis in south Florida. Am J Ophthalmol 1980;90:38-47.  Back to cited text no. 25
    
26.
Panda A, Sharma N, Das G, Kumar N, Satpathy G. Mycotic keratitis in children: epidemiological and microbiologic evaluation. Cornea 1997;16:295-99.  Back to cited text no. 26
    
27.
Thomas PA. Mycotic keratitis-an underestimated mycosis. J Med Vet Mycol 1994;32:235-36.  Back to cited text no. 27
    
28.
Mino de Kasper H, Zoulek G, Paredes ME, Alborno R, Medina D, Centurian de Morinigo M, et al. Mycotic keratitis in Paraguay. Mycoses 1991;34:251-54.  Back to cited text no. 28
    
29.
Gugnani HC, Talwar RS, Njoku-Obi AN, Kodilinye HC. Mycotic keratitis in Nigeria. A study of 21 cases. Br J Ophthalmol 1976;60:607-13.  Back to cited text no. 29
[PUBMED]    
30.
Mselle J. Fungal keratitis as an indicator of HIV infection in Africa. Trop Doct 1999;29:133-35.  Back to cited text no. 30
    
31.
Houang E, Lam D, Fan D, Seal D. Microbial keratitis in Hong Kong: relationship with climate, environment, and contact lens-disinfection. Trans R Soc Trop Med Hyg 2001;95:361-67.  Back to cited text no. 31
    
32.
Wong TY, Fong KS, Tan DTH. Clinical and microbiological spectrum of fungal keratitis in Singapore: a 5-year retrospective study. Int Ophthalmol 1997;21:127-30.  Back to cited text no. 32
    



 
 
    Tables

  [Table - 1], [Table - 2], [Table - 3], [Table - 4], [Table - 5]


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International Journal of Nanomedicine. 2022; Volume 17: 2283
[Pubmed] | [DOI]
18 A retrospective observational study of mycotic keratitis in Saveetha Hospitals, Chennai
G Srinivasan, Madhumitha PS , N Divya
International Journal of Clinical and Experimental Ophthalmology. 2022; 6(2): 038
[Pubmed] | [DOI]
19 A study on demographic profile and predisposing factors of corneal ulcer in South India
Zainu Shams, Adithya Anand, Pradeep G N
Indian Journal of Clinical and Experimental Ophthalmology. 2022; 8(4): 525
[Pubmed] | [DOI]
20 Successful culture of Acanthamoeba remains a key towards diagnosis of unusual clinical presentation of keratitis: A first case report from chhattisgarh
ArchanaB Wankhade, Priyadarshini Patro, Neeta Mishra, Padma Das
Journal of Family Medicine and Primary Care. 2021; 10(10): 3904
[Pubmed] | [DOI]
21 PROFILE OF KERATOMYCOSIS IN A TERTIARY CARE TEACHING HOSPITAL IN WESTERN UTTAR PRADESH, INDIA
Vandana Sardana, Sameer R Verma
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. 2021; : 1
[Pubmed] | [DOI]
22 Mycotic Keratitis—A Global Threat from the Filamentous Fungi
Jeremy J. Hoffman, Matthew J. Burton, Astrid Leck
Journal of Fungi. 2021; 7(4): 273
[Pubmed] | [DOI]
23 EPIDEMIOLOGICAL PROFILE OF FUNGAL KERATITIS IN PATIENTS ATTENDING A TERTIARY CARE CENTRE IN BIHAR
Kumar Vikram, Gyan Bhaskar, Shailesh Kumar, Rakesh Kumar, Namrata Kumari
INDIAN JOURNAL OF APPLIED RESEARCH. 2021; : 32
[Pubmed] | [DOI]
24 Role of anterior segment optical coherence tomography in the evaluation of microbial keratitis
Isha Chaturvedi, Kamaljeet Singh, Jagriti Rana, Kshama Dwivedi, Reena Sachan
Indian Journal of Clinical and Experimental Ophthalmology. 2021; 7(3): 548
[Pubmed] | [DOI]
25 Urgent unmet needs in the care of bacterial keratitis: An evidence-based synthesis
Lawson Ung, James Chodosh
The Ocular Surface. 2021;
[Pubmed] | [DOI]
26 Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis
Rohan Bir Singh, Sujata Das, James Chodosh, Namrata Sharma, Michael E. Zegans, Regis P. Kowalski, Vishal Jhanji
Progress in Retinal and Eye Research. 2021; : 101028
[Pubmed] | [DOI]
27 Development of a novel micro-bead force spectroscopy approach to measure the ability of a thermo-active polymer to remove bacteria from a corneal model
J. Pattem, T. Swift, S. Rimmer, T. Holmes, S. MacNeil, J. Shepherd
Scientific Reports. 2021; 11(1)
[Pubmed] | [DOI]
28 Epidemiology, clinical profile and treatment outcomes of bacterial and fungal keratitis
Nabila A. Mabrouk, Mohamed Farouk Abdelkader, Mohammed A. Abdelhakeem, Khaled M. Mourad, Ahmed A. Abdelghany
International Ophthalmology. 2021;
[Pubmed] | [DOI]
29 The prevalence of characteristic corneal ulcer patients in sanglah general hospital, in indonesia
Sinta Wiranata, I Wayan Eka Sutyawan, I Putu Budhiastra
World Journal of Current Medical and Pharmaceutical Research. 2021; : 81
[Pubmed] | [DOI]
30 A human corneal ulcer caused by Thelazia callipaeda in Southwest China: case report
Xiaoxing Wei, Bo Liu, Yijian Li, Ke Wang, Lixia Gao, Yuli Yang
Parasitology Research. 2020; 119(10): 3531
[Pubmed] | [DOI]
31 Clinico-Aetiological Scenario and Microbiological Profile in Corneal Ulcer Cases in a Tertiary Eye Care Centre in Southern Assam
Nilanjan Kaushik Thakur, Atanu Chakravarty, Shibashis Deb, Subhashish Deb, Ankita Narula
Journal of Evolution of Medical and Dental Sciences. 2020; 9(10): 753
[Pubmed] | [DOI]
32

Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal

Leena Bajracharya, Asta Ram Bade, Reeta Gurung, Kavita Dhakhwa
Clinical Ophthalmology. 2020; Volume 14: 3219
[Pubmed] | [DOI]
33 Comparison of fungal and bacterial keratitis between tropical and subtropical Taiwan: a prospective cohort study
Chih-An Chen, Shiuh-Liang Hsu, Ching-Hsi Hsiao, David Hui-Kang Ma, Chi-Chin Sun, Hun-Ju Yu, Po-Chiung Fang, Ming-Tse Kuo
Annals of Clinical Microbiology and Antimicrobials. 2020; 19(1)
[Pubmed] | [DOI]
34 Epidemiological and Microbiological Profile of Suppurative Corneal Ulcer in a Tertiary Care Hospital in Eastern India
Krittika Palchoudhury, Sagar Karmakar, Chandana Chakraborti
Journal of Evidence Based Medicine and Healthcare. 2020; 7(29): 1428
[Pubmed] | [DOI]
35 Bacterial and fungal causes of infectious keratitis among patients attending Research Institute of Ophthalmology
Amal Ibrahim Abouzeid, Somaia Abd Ellatif Eissa, Amal E. Aboelnour, Alaa Mohamed Reda Awad
Bulletin of the National Research Centre. 2020; 44(1)
[Pubmed] | [DOI]
36 Clinico-etiological profile of microbial keratitis: A pilot study from the foothills of Himalayas
Ranjana Rohilla, Suneeta Meena, Neeti Gupta, Aroop Mohanty, Neelam Kaistha, Pratima Gupta, Amit Mangla, USasi Rekha, BalramJi Omar
Indian Journal of Ophthalmology. 2020; 68(10): 2323
[Pubmed] | [DOI]
37 Etiological spectrum of infectious keratitis in the era of MALDI-TOF-MS at a tertiary care hospital
Ranjana Rohilla, Suneeta Meena, Aroop Mohanty, Neeti Gupta, Neelam Kaistha, Pratima Gupta, Amit Mangla, Anshu Singh
Journal of Family Medicine and Primary Care. 2020; 9(9): 4576
[Pubmed] | [DOI]
38 A PROSPECTIVE STUDY OF EPIDEMIOLOGICAL FEATURES, MICROBIOLOGICAL DIAGNOSIS & TREATMENT OUTCOME OF INFECTIVE KERATITIS
Sanjay Kumar Goyal, Uma Meena, D.S. Meena, Vijay Gupta
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. 2020; : 1
[Pubmed] | [DOI]
39 Management of infective corneal ulcers in a high-income developing country
Tahra AlMahmoud, Mohamed Elhanan, Mohamed H. Elshamsy, Hanan N. Alshamsi, Fikri M. Abu-Zidan
Medicine. 2019; 98(51): e18243
[Pubmed] | [DOI]
40 The Spectrum of Microbial Keratitis: An Updated Review
Christopher Bartimote, John Foster, Stephanie Watson
The Open Ophthalmology Journal. 2019; 13(1): 100
[Pubmed] | [DOI]
41 MICROBIAL KERATITIS- MICROBIAL PATTERN IN A TERTIARY CARE CENTRE OF A METROPOLITAN CITY
Vrunda MorePatil, Sapna Malik, Minu Ramakrishnan, Jyothirlatha Bangera
Journal of Evolution of Medical and Dental Sciences. 2019; 8(14): 1145
[Pubmed] | [DOI]
42 A CLINICAL STUDY OF SUPPURATIVE KERATITIS
Nikhil R. P, Himabindu Himabindu, Manaswini D
Journal of Evolution of Medical and Dental Sciences. 2019; 8(3): 200
[Pubmed] | [DOI]
43 Incidence of various causes of infectious keratitis in the part of rural central India and its visual morbidity: Prospective hospital-based observational study
PratikNarendra Mohod, ArchanaSunil Nikose, PradnyaMukesh Laddha, Shadwala Bharti
Journal of Clinical Ophthalmology and Research. 2019; 7(1): 31
[Pubmed] | [DOI]
44 ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF BACTERIAL AND FUNGAL OCULAR ISOLATES FROM TERTIARY CARE OPHTHALMIC HOSPITALS IN CHENNAI
Senthilvadivu C, Stalin M
Journal of Evolution of Medical and Dental Sciences. 2018; 7(15): 1868
[Pubmed] | [DOI]
45 Fungal Keratitis Associated With Airborne Organic Debris and Soft Contacts Lenses: Case Reports and Review of the Literature
Michael J. Hodkin, Ryan C. Gustus
Eye & Contact Lens: Science & Clinical Practice. 2018; 44(1): S16
[Pubmed] | [DOI]
46 Mast Cell Activation Protects Cornea by Promoting Neutrophil Infiltration via Stimulating ICAM-1 and Vascular Dilation in Fungal Keratitis
Yanting Xie, Hongmin Zhang, Susu Liu, Guoming Chen, Siyu He, Zhijie Li, Liya Wang
Scientific Reports. 2018; 8(1)
[Pubmed] | [DOI]
47 Changing trends in fungal and bacterial profile of infectious keratitis at a tertiary care hospital: A six-year study
Priyamvada Roy, Shukla Das, N.P. Singh, Rumpa Saha, Garima Kajla, K. Snehaa, V.P. Gupta
Clinical Epidemiology and Global Health. 2017; 5(1): 40
[Pubmed] | [DOI]
48 Non-contact lens related Acanthamoeba keratitis
Prashant Garg, Paavan Kalra, Joveeta Joseph
Indian Journal of Ophthalmology. 2017; 65(11): 1079
[Pubmed] | [DOI]
49 A STUDY ON EPIDEMIOLOGY AND AETIOLOGY OF SUPPURATIVE CORNEAL ULCER IN SUBHIMALAYAN PART OF WEST BENGAL
Gangotri Barui, Soumyadeep Majumdar, Udit Raj Sharma, Shyama Prasad Saha
Journal of Evidence Based Medicine and Healthcare. 2017; 4(67): 4001
[Pubmed] | [DOI]
50 EPIDEMIOLOGICAL AND MICROBIOLOGICAL PROFILE OF SUPPURATIVE KERATITIS
Anshu Sharma, Himanshu Sardana, Sarita Aggarwal, Varun Aggarwal, Awantika Bhadauria
Journal of Evidence Based Medicine and Healthcare. 2017; 4(8): 423
[Pubmed] | [DOI]
51 A STUDY OF THE AETIOLOGICAL AND CLINICAL FEATURES OF INFECTED CORNEAL ULCERS AS STUDIED IN A RURAL POPULATION
Padmajothi Mudianur Subrahmanyam, Anjali Lita Roche
Journal of Evidence Based Medicine and Healthcare. 2017; 4(14): 789
[Pubmed] | [DOI]
52 ANALYSIS OF CASES OF MICROBIAL KERATITIS IN A MEDICAL COLLEGE IN VISAKHAPATNAM
Ratna Kumari B. V. S, Madusudana Rao K. V, Raja Rajeswar M
Journal of Evidence Based Medicine and Healthcare. 2016; 3(32): 1491
[Pubmed] | [DOI]
53 TO STUDY THE RESULT OF EMPIRICAL TREATMENT OUTCOME OF CORNEAL ULCER PATIENTS WHO REFUSED CORNEAL SCRAPING IN EASTERN PART OF RURAL INDIA
Debdas Mukherjee, Khevna Patel, Nivedita Choudhury, Alok Kumar, Debtanu Mukherjee
Journal of Evidence Based Medicine and Healthcare. 2016; 3(67): 3649
[Pubmed] | [DOI]
54 Fungal keratitis: dealing with a diverse kingdom of ocular assailants
Charles NJ McGhee, Bia Z Kim
Clinical & Experimental Ophthalmology. 2016; 44(9): 755
[Pubmed] | [DOI]
55 A comparative, retrospective, observational study of the clinical and microbiological profiles of post-penetrating keratoplasty keratitis
I-Huang Lin, Yi-Sheng Chang, Sung-Huei Tseng, Yi-Hsun Huang
Scientific Reports. 2016; 6(1)
[Pubmed] | [DOI]
56 Corneal infections in the 21st century
Hon Shing Ong, Melanie C Corbett
Postgraduate Medical Journal. 2015; 91(1080): 565
[Pubmed] | [DOI]
57 Filamentous fungal infections of the cornea: a global overview of epidemiology and drug sensitivity
László Kredics,Venkatapathy Narendran,Coimbatore Subramanian Shobana,Csaba Vágvölgyi,Palanisamy Manikandan
Mycoses. 2015; 58(4): 243
[Pubmed] | [DOI]
58 Trends in bacterial and fungal keratitis in South India, 2002-2012
P. Lalitha,N. V. Prajna,G. Manoharan,M. Srinivasan,J. Mascarenhas,M. Das,S. S. DćSilva,T. C. Porco,J. D. Keenan
British Journal of Ophthalmology. 2015; 99(2): 192
[Pubmed] | [DOI]
59 Clinical and microbiological characteristics of corneal ulcers in a Thai referral center
Kosol Kampitak, Haruetai Suntisetsin, Tasanee Sirikul
Asian Biomedicine. 2014; 8(2): 275
[Pubmed] | [DOI]
60 Clinical and epidemiological characteristics of infectious keratitis in Paraguay
Martin M. Nentwich,M. Bordón,D. Sánchez di Martino,A. Ruiz Campuzano,W. Martínez Torres,F. Laspina,S. Lichi,M. Samudio,N. Farina,Rosa R. Sanabria,Herminia Mino de Kaspar
International Ophthalmology. 2014;
[Pubmed] | [DOI]
61 Clinical utility of caspofungin eye drops in fungal keratitis
Chin Fen Neoh,Mark Daniell,Sharon C.-A. Chen,Kay Stewart,David C.M. Kong
International Journal of Antimicrobial Agents. 2014;
[Pubmed] | [DOI]
62 In VitroAntibiotic Susceptibility ofPseudomonas aeruginosaCorneal Ulcer Isolates
Shikha Gupta,Sudeep Mittal,Niranjan Nayak,Gita Satpathy,Sudarshan Khokhar,Tushar Agarwal
Ocular Immunology and Inflammation. 2014; : 1
[Pubmed] | [DOI]
63 Vision-Related Quality of Life in Patients with Infectious Keratitis
Yimin Li,Jiaxu Hong,Anji Wei,Xin Wang,Yan Chen,Xinhan Cui,Xinghuai Sun,Zuguo Liu,Jianjiang Xu
Optometry and Vision Science. 2014; : 1
[Pubmed] | [DOI]
64 Series of Five Cases of Papulaspora equi Keratomycosis
Satheesh S. T. Selvin,Sanita M. G. Korah,Joy S. Michael,Promila M. Raj,Pushpa Jacob
Cornea. 2014; 33(6): 640
[Pubmed] | [DOI]
65 Microbial Keratitis Profile at a University Hospital in Hong Kong
Tracy H. T. Lai,Vishal Jhanji,Alvin L. Young
International Scholarly Research Notices. 2014; 2014: 1
[Pubmed] | [DOI]
66 Comparison of Mycotic Keratitis with Nonmycotic Keratitis: An Epidemiological Study
Mohammad M. Khater,Nehal S. Shehab,Anwar S. El-Badry
Journal of Ophthalmology. 2014; 2014: 1
[Pubmed] | [DOI]
67 Role of Liquid Culture Media in the Laboratory Diagnosis of Microbial Keratitis
Yogesh Bhadange,Savitri Sharma,Sujata Das,Srikant K. Sahu
American Journal of Ophthalmology. 2013; 156(4): 745
[Pubmed] | [DOI]
68 Posttraumatic Keratitis Caused by Elizabethkingia meningosepticum
Elif Erdem,Sibel Abdurrahmanoglu,Filiz Kibar,Meltem Yagmur,Fatih Koksal,Reha Ersoz
Eye & Contact Lens: Science & Clinical Practice. 2013; 39(5): 361
[Pubmed] | [DOI]
69 Changing Referral Patterns of Infectious Corneal Ulcers to a Tertiary Care Facility in South India – 7-year analysis
Sabyasachi Sengupta,Krishnan Thiruvengadakrishnan,Ravilla D. Ravindran,Manivasagam C. Vaitilingam
Ophthalmic Epidemiology. 2012; 19(5): 297
[Pubmed] | [DOI]
70 Candida Keratitis : Emerging Problem in India
Jayangshu Sengupta, Archana Khetan, Suman Saha, Debdulal Banerjee, Nibaran Gangopadhyay, Dipanjan Pal
Cornea. 2012; 31(4): 371
[VIEW] | [DOI]
71 Diagnosis and treatment outcome of mycotic keratitis at a tertiary eye care center in eastern india
Bibhudutta Rautaraya, Savitri Sharma, Sarita Kar, Sujata Das, Srikant K Sahu
BMC Ophthalmology. 2011; 11(1): 39
[VIEW] | [DOI]
72 Geographic variations in microbial keratitis: An analysis of the peer-reviewed literature
Shah, A., Sachdev, A., Coggon, D., Hossain, P.
British Journal of Ophthalmology. 2011; 95(6): 762-767
[Pubmed]
73 Keratomycosis with superadded bacterial infection due to corticosteroid abuse-a case report
Kumar, A., Pandya, S., Madan, M., Kavathia, G.
Journal of Clinical and Diagnostic Research. 2010; 4(4): 2918-2921
[Pubmed]
74 Epidemiology and etiologic diagnosis of infectious keratitis in Uberlandia, Brazil
Furlanetto, R.L., Andreo, E.G.V., Finotti, I.G.A., Arcieri, E.S., Ferreira, M.A., Rocha, F.J.
European Journal of Ophthalmology. 2010; 20(3): 498-503
[Pubmed]
75 Etiologic Diagnosis of Corneal Ulceration at a Tertiary Eye Center in Kathmandu, Nepal :
Michael R Feilmeier, Kavitha R Sivaraman, Matt Oliva, Geoffrey C Tabin, Reeta Gurung
Cornea. 2010; 29(12): 1380
[VIEW] | [DOI]
76 Analysis of the risk factors predisposing to fungal, bacterial & Acanthamoeba keratitis in south India
Bharathi, M.J., Ramakrishnan, R., Meenakshi, R., Shivakumar, C., Lional Raj, L.
Indian Journal of Medical Research. 2009; 130(6): 749 -757
[Pubmed]
77 Epidemiological characteristics, predisposing factors and microbiological profiles of infectious corneal ulcers: The Portsmouth corneal ulcer study
Ibrahim, Y.W., Boase, D.L., Cree, I.A.
British Journal of Ophthalmology. 2009; 93(10): 1319-1324
[Pubmed]
78 Shifting trends of pathogenic bacteria and antibiotic resistance in bacterial keratitis
Wang, J., Zhao, M.
Chinese Ophthalmic Research. 2008; 26(11): 868-872
[Pubmed]
79 Incidence and clinical features of contact lens related microbial keratitis
Wajin, W.A.S., Qader, A.M.A., Shaharuddin, B., Hitam, W.H.W.
International Medical Journal. 2008; 15(3): 221-223
[Pubmed]
80 Comparative analysis of the tear protein profile in mycotic keratitis patients
Ananthi, S., Chitra, T., Bini, R., Prajna, N.V., Lalitha, P., Dharmalingam, K.
Molecular Vision. 2008; 14: 500-507
[Pubmed]
81 Microbial keratitis: Aetiological diagnosis and clinical features in patients admitted to Hospital Universiti Sains Malaysia
Norina, T.J., Raihan, S., Bakiah, S., Ezanee, M., Liza-Sharmini, A.T., Wan Hazzabah, W.H.
Singapore Medical Journal. 2008; 49(1): 67-71
[Pubmed]
82 Mycotic keratitis: an overview of diagnosis and therapy
P. K. Shukla, M. Kumar, G. B. S. Keshava
Mycoses. 2008; 51(3): 183
[VIEW] | [DOI]
83 A study of the spectrum of Acanthamoeba keratitis: A three-year study at a tertiary eye care referral center in South India
Bharathi, J.M., Srinivasan, M., Ramakrishnan, R., Meenakshi, R., Padmavathy, S., Lalitha, P.N.
Indian Journal of Ophthalmology. 2007; 55(1): 37-42
[Pubmed]
84 Microbial keratitis in South India: Influence of risk factors, climate, and geographical variation
Bharathi, M.J., Ramakrishnan, R., Meenakshi, R., Padmavathy, S., Shivakumar, C., Srinivasan, M.
Ophthalmic Epidemiology. 2007; 14(2): 61-69
[Pubmed]
85 Evaluation of Polymerase Chain Reaction-Based Ribosomal DNA Sequencing Technique for the Diagnosis of Mycotic Keratitis
Ghosh, A., Basu, S., Datta, H., Chattopadhyay, D.
American Journal of Ophthalmology. 2007; 144(3): 396-403
[Pubmed]
86 Infective keratitis: A challenge to Indian ophthalmologists
Srinivasan, M.
Indian Journal of Ophthalmology. 2007; 55(1): 5-6
[Pubmed]
87 Evaluation of Polymerase Chain Reaction-Based Ribosomal DNA Sequencing Technique for the Diagnosis of Mycotic Keratitis
Abhrajyoti Ghosh,Sayan Basu,Himadri Datta,Dhrubajyoti Chattopadhyay
American Journal of Ophthalmology. 2007; 144(3): 396
[Pubmed] | [DOI]
88 Microbial Keratitis
Samar K. Basak
Ophthalmology. 2006; 113(11): 2115
[Pubmed] | [DOI]
89 Microbial Keratitis
Basak, S.K.
Ophthalmology. 2006; 113(11): 2115-2116
[Pubmed]
90 Prevalence and spectrum of bacterial co-infection during fungal keratitis
Pate, J.C., Jones, D.B., Wilhelmus, K.R.
British Journal of Ophthalmology. 2006; 90(3): 289-292
[Pubmed]
91 Dematiaceous fungal keratitis: Its prevalence and sensitivity pattern of the isolates
Jeya, M., Udhaya, V., Vasudevan, R.
Biomedicine. 2006; 26(1-2): 29-34
[Pubmed]
92 Authorćs reply
Basak, S.K., Basak, S., Mohanta, A., Bhowmick, A.
Indian Journal of Ophthalmology. 2005; 53(2): 143
[Pubmed]
93 Epidemiological and microbiological diagnosis of suppurative keratitis in gangetic West Bengal, Eastern India
Thomas, P.A., Kaliamurthy, J., Geraldine, P.
Indian Journal of Ophthalmology. 2005; 53(2): 143
[Pubmed]



 

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