• Users Online: 109
  • Home
  • Print this page
  • Email this page

   Table of Contents      
BRIEF REPORT
Year : 2006  |  Volume : 54  |  Issue : 3  |  Page : 204-206

Combined central retinal artery and vein occlusion secondary to systemic non-Hodgkin's lymphoma


Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India

Correspondence Address:
Dhananjay Shukla
Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, 1 Anna Nagar, Madurai - 625 020, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.27077

Rights and Permissions
  Abstract 

We report a rare case of low-grade systemic B-cell non-Hodgkin's lymphoma (NHL) causing central retinal artery and vein occlusion, which was the only manifestation of disease recurrence. A young man with resolved systemic NHL underwent fluorescein angiography, magnetic resonance imaging and computed tomography to investigate a severe unilateral visual loss. A combined vascular occlusion was observed in the right eye. Neuroimaging detected optic nerve infiltration; but no systemic/ central nervous system involvement was observed. The patient was treated with high-doses of corticosteroids and optic nerve irradiation. The optic neuropathy and vascular occlusion were resistant to treatment. The subsequent neovascular glaucoma was treated by panretinal photocoagulation, which relieved the pain, but vision was not recovered. No further recurrence was observed over the following year.

Keywords: Central retinal artery, central retinal vein, combined occlusion, non-hodgkin′s lymphoma.


How to cite this article:
Shukla D, Arora A, Hadi KM, Kumar M, Baddela S, Kim R. Combined central retinal artery and vein occlusion secondary to systemic non-Hodgkin's lymphoma. Indian J Ophthalmol 2006;54:204-6

How to cite this URL:
Shukla D, Arora A, Hadi KM, Kumar M, Baddela S, Kim R. Combined central retinal artery and vein occlusion secondary to systemic non-Hodgkin's lymphoma. Indian J Ophthalmol [serial online] 2006 [cited 2022 Aug 13];54:204-6. Available from: https://www.ijo.in/text.asp?2006/54/3/204/27077

In a post-treatment non-Hodgkin's lymphoma (NHL), ocular lymphoma may be the first sign of a systemic relapse.[1] We report, probably the first case of a benign systemic NHL-in-remission, causing central retinal artery and vein occlusion, without any other associated central nervous system (CNS) involvement.


  Case Report Top


A 28-year-old man presented with abdominal pain to his physician. There was no history of weight loss or fever. Ultrasonography of abdomen showed hepatomegaly and abdominal lymphadenopathy. Systemic examination showed palpable axillary lymph nodes. Fine-needle aspiration cytology from the left axillary lymph nodes showed a nodal marginal zone B-cell NHL. Bone marrow biopsy was normal. Six cycles of chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisolone were given. The patient responded well, with complete remission of the lymphoma, radiologically and ultrasonographically.

Four months later, his right eye suffered a sudden drop in visual acuity to light perception; the left eye was 20/20. An afferent pupillary defect was noted in the right eye. The anterior segment and angles were unremarkable on slit-lamp biomicroscopy and gonioscopy in either eye. Intra-ocular pressure was normal in both the eyes. Fundus examination of the right eye showed a grossly swollen optic disc, pale macular edema with a cherry-red spot, venous tortuosity and extensive retinal hemorrhages [Figure - 1]a. Fluorescein angiography showed no retinal vascular perfusion [Figure - 1]b. Left fundus was normal. Magnetic resonance imaging (MRI) and computerized tomography (CT) showed thickening of the right optic nerve and enhancement of the optic-nerve-sheath complex in a post-contrast study [Figure - 2]. CNS was not involved. Chest X-ray, abdominal ultrasound and CT failed to detect any systemic recurrence. Intravenous methyl prednisolone (15 mg/kg/day) was given for three days, followed by oral prednisolone, 1 mg/kg. The patient was referred to an oncologist for radiotherapy of the optic nerve. Two months later, he returned with pain in right eye. The vision remained light perception. Anterior segment examination showed a steamy cornea, a persistent afferent pupillary defect and rubeosis of the iris and angles. Intraocular pressure was 40 mmHg by applanation tonometry. Fundus showed reduced severity of hemorrhages and disc edema. Panretinal photocoagulation was done to treat the neovascular glaucoma. The rubeosis and pain regressed; a stable ocular and systemic status was observed for the next 12 months.


  Discussion Top


NHLs are a heterogeneous group of malignancies of the lymphoid system. The WHO classification of hematopoietic and lymphoid tumors classifies lymphomas into B-cell and T-cell neoplasms; the former account for more than 85% of all lymphomas.[2] Intraocular lymphomas are usually B-cell neoplasms.[1] While retinal hemorrhages and cotton-wool spots may occur due to anemia or thrombocytopenia, direct retinal involvement is extremely rare in systemic NHL.[3]

There are three reports of combined vascular occlusion, secondary to NHL, in the literature.[4],[5],[6] These occlusions were primarily due to lymphomatous infiltration of the optic nerve. Septic emboli and paraneoplastic hypercoagulability were the additional causes. We also suspected an infiltrative optic neuropathy, with subsequent infiltration/compression of the vascular wall, in our case. Similar to the report of Saatci et al .,[4] our case also experienced a vascular occlusion during disease remission. However, there were some distinctive features: In spite of a well-differentiated systemic B-cell lymphoma, our patient suffered a severe combined vascular occlusion, with neovascular glaucoma. We were unable to find such an association in the literature; the above-mentioned combined occlusions occurred due to large/mixed B-cell or T-cell lymphoma. Further, in the previous reports of optic nerve infiltration and combined vascular occlusion in the background of regressing NHL, CNS was involved in the relapse.[4],[5] A systemic/CNS relapse of lymphoma did not occur in our patient. Optic neuropathy may occur as the sole manifestation of NHL recurrence.[7]

We observed combined vascular occlusion as the only manifestation of recurrent systemic NHL. Visual prognosis was poor in spite of aggressive treatment with corticosteroids and irradiation. Even a benign systemic NHL can be deceptively destructive to the eyes; it is important to explain the guarded visual prognosis to the patient, even after achieving successful remission of the tumor.

 
  References Top

1.
Harbour JW, Char DH. Intraocular lymphoid tumors. In : Guyer DR, Yannuzzi LA, Chang S, Shields JA, Green WR, editors. Retina-Vitreous-Macula . W.B. Saunders Co: Philadelphia; 1994. p. 1204-16.  Back to cited text no. 1
    
2.
Coffey J, Hodgson DC, Gospodarowicz MK. Therapy of non-Hodgkin's lymphoma. Eur J Nucl Med Mol Imaging 2003;30:S28-36.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.
Dhaliwal RS, Schachat AP. Leukemias and lymphomas. In : Ryan SJ, editor. Retina . Mosby: St Louis; 2001. p. 842-58.  Back to cited text no. 3
    
4.
Saatci AO, Duzovali O, Ozbek Z, Saatci I, Sarialioglu F. Combined occlusion of central retinal artery and vein occlusion in a child with systemic non-Hodgkin's lymphoma. Int Ophthalmol 1999;22:125-7.  Back to cited text no. 4
    
5.
Guyer DR, Green WR, Schachat AP, Bastacky S, Miller NR. Bilateral ischemic optic neuropathy and retinal vascular occlusions associated with lymphoma and sepsis. Clinicopathologic correlation. Ophthalmology 1990;97:882-8.   Back to cited text no. 5
    
6.
Kling F, Macarez R, Robinet A, Kouassi FX, Colin J. Mixed retinal thrombosis in a patient carrying prothrombin gene mutation in a homozygote state. J Fr Ophtalmol 1999;22:979-81.   Back to cited text no. 6
    
7.
Kay MC. Optic neuropathy secondary to lymphoma. J Clin Neuroophthalmol 1986;6:31-4.  Back to cited text no. 7
    


    Figures

  [Figure - 1], [Figure - 2]


This article has been cited by
1 Idiopathic combined retinal vessels occlusion in a pregnant woman: a case report
Mohammadreza Mehrabi Bahar, Seyedeh Noushin Ghalandarpoor-Attar, Azadeh Shabani, Sedigheh Hantoushzadeh, Seyed Ali Tabatabaei, Seyedeh Mojgan Ghalandarpoor-Attar
Journal of Medical Case Reports. 2022; 16(1)
[Pubmed] | [DOI]
2 Isolated Infiltrative Optic Neuropathy in an Acute Lymphoblastic Leukemia Relapse
Huey Chuin Kuan, Mushawiahti Mustapha, Shelina Oli Mohamed, Roslin Azni Abdul Aziz, C Khai Loh, Fazarina Mohammed, Ainal Adlin Naffi, Othmaliza Othman, Rona A Nasaruddin, Hamidah Alias
Cureus. 2022;
[Pubmed] | [DOI]
3 Combined retinal vascular occlusion: Demography, clinical features, visual outcome, systemic co-morbidities, and literature review
Vishal Raval, Sameera Nayak, Merlin Saldanha, Subhadra Jalali, RajeevReddy Pappuru, Raja Narayanan, Taraprasad Das
Indian Journal of Ophthalmology. 2020; 68(10): 2136
[Pubmed] | [DOI]
4 Combined branch retinal vein and branch retinal artery occlusion – clinical features, systemic associations, and outcomes
Sabyasachi Sengupta, Utsab Pan
Indian Journal of Ophthalmology. 2017; 65(3): 238
[Pubmed] | [DOI]
5 Acute visual loss: Just the beginning?
Ayse Ilksen Colpak,Ilkay Isikay,Melike Mut,Figen Soylemezoglu,Tulay Kansu,Rod Foroozan
Survey of Ophthalmology. 2014;
[Pubmed] | [DOI]
6 Optic nerve lymphoma: Report of two cases and review of the literature
Jennifer L. Kim,Pia R. Mendoza,Alia Rashid,Brent Hayek,Hans E. Grossniklaus
Survey of Ophthalmology. 2014;
[Pubmed] | [DOI]
7 COMBINED CRVO WITH CRAO IN A PATIENT WITH PROTEIN C DEFICIENCY
Shachi Desai,Navendu Rai,Pandurang Kulkarni,Sundaram Natarajan
Retinal Cases & Brief Reports. 2014; 8(2): 145
[Pubmed] | [DOI]
8 CATASTROPHIC ANTIPHOSPHOLIPID ANTIBODY SYNDROME AND COCAINE ABUSE ASSOCIATED WITH BILATERAL RETINAL VASCULAR OCCLUSIONS :
John P Campbell, Bryn M Burkholder, James P Dunn
Retinal Cases & Brief Reports. 2011; 5(4): 318
[VIEW] | [DOI]
9 Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: Unusual ocular manifestations in allergic granulomatous angiitis
De Salvo, G., Li Calzi, C., Anastasi, M., Lodato, G.
European Journal of Ophthalmology. 2009; 19(2): 314-317
[Pubmed]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Abstract
Case Report
Discussion
References
Article Figures

 Article Access Statistics
    Viewed5519    
    Printed134    
    Emailed5    
    PDF Downloaded391    
    Comments [Add]    
    Cited by others 9    

Recommend this journal