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REVIEW ARTICLE
Year : 2007  |  Volume : 55  |  Issue : 3  |  Page : 173-183

Global variation and pattern changes in epidemiology of uveitis


Aravind Eye Hospital and PG Institute of Ophthalmology, 1, Anna Nagar, Madurai - 625 020, India

Date of Submission13-Jan-2007
Date of Acceptance05-Mar-2007

Correspondence Address:
S R Rathinam
Aravind Eye Hospital and PG Institute of Ophthalmology, 1, Anna Nagar, Madurai - 625 020, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.31936

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  Abstract 

Uveitis, a complex intraocular inflammatory disease results from several etiological entities. Causes of uveitis are known to vary in different populations depending upon the ecological, racial and socioeconomic variations of the population studied. Tropical countries are unique in their climate, prevailing pathogens and in the existing diseases, which further influence the epidemiological and geographical distribution of specific entities. We provide an overview of the pattern of uveitis of 15221 cases in 24 case series reported from several countries over 35 years (1972-2007) and we integrate it with our experience of an additional 8759 cases seen over six years (1996-2001) at a large community-based eye hospital. Uveitis accounted for 0.8% of our hospital-based outpatient visits. The uveitis was idiopathic in 44.6%, the most commonly identified entities in the cohort included leptospiral uveitis (9.7%), tuberculous uveitis (5.6%) and herpetic uveitis (4.9%). The most common uveitis in children below 16 years (616 patients; 7.0% of the total cohort) was pediatric parasitic anterior uveitis, (182 children, 29.5% of the pediatric cohort), whereas the most common uveitis in patients above 60 years (642 patients; 7.3% of the total cohort) was herpetic anterior uveitis, (78 patients, 12.1% of the elderly cohort). Etiologies varied with the age group of the patients. As in other tropical countries, a high prevalence of infectious uveitis was seen in this population.

Keywords: Epidemiology, tropical country, uveitis


How to cite this article:
Rathinam S R, Namperumalsamy P. Global variation and pattern changes in epidemiology of uveitis. Indian J Ophthalmol 2007;55:173-83

How to cite this URL:
Rathinam S R, Namperumalsamy P. Global variation and pattern changes in epidemiology of uveitis. Indian J Ophthalmol [serial online] 2007 [cited 2022 Dec 4];55:173-83. Available from: https://www.ijo.in/text.asp?2007/55/3/173/31936

Distribution of various etiologies of uveitis from different countries

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Distribution of various etiologies of uveitis from different countries

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Demographic and onset characteristics of uveitis from different countries

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Demographic and onset characteristics of uveitis from different countries

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Causes of diffuse uveitis

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Causes of diffuse uveitis

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Causes of posterior uveitis

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Causes of posterior uveitis

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Causes of intermediate uveitis

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Causes of intermediate uveitis

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Causes of anterior uveitis

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Causes of anterior uveitis

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Etiological classification by age group distribution

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Etiological classification by age group distribution

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Clinical characteristics

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Clinical characteristics

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Demographic characteristics

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Demographic characteristics

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Uveitis includes a large group of diverse inflammatory diseases, the frequencies of which vary considerably by geographic location around the world.[1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23] Awareness of such regional differences in the disease pattern is essential in deriving a region-specific list of differential diagnoses which in turn facilitates the final diagnosis. Factors contributing to such regional variations in the causes of uveitis are complex and incompletely understood, but include both host and environmental factors.[6],[8],[24],[25] Among the environmental factors, the most important appears to be the regional distribution of various pathogens,[24],[25],[26],[27],[28],[29] including relatively new and emerging agents. South India has a tropical climate and depends to a large extent on an agriculture-based economy. Although agricultural communities constitute a major section of the global population, accurate estimates of the causes of uveitis in such regions and populations are largely unavailable. In this paper, we present the causes and characteristics of uveitis seen over a six-year period in a large community-based eye hospital in South India and we have compared the pattern of uveitis of this population with the data from other parts of the world including the developed and developing world. [1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23]

Method of literature search

The Medline database was searched electronically using the terms uveitis, epidemiology, tropical, infectious and noninfectious uveitis. Pertinent articles from the English language literature were primarily selected. Additionally, references cited in the above articles were also gathered. Inclusion or exclusion of any article in the text was based on its relevance and usefulness.

Patients, methods and results of present study

Case records of patients examined in the uveitis clinic of a community-based eye hospital between January 1996 and December 2001, were collected for analysis. Demographic and ocular findings were recorded in a computerized database. Details on disease severity, laterality, chronicity, ocular signs and associated systemic conditions were noted. All patients had a systematic uveitis workup after a preliminary examination by a general ophthalmologist and a nonophthalmologist physician. Anatomical location of the inflammation was assigned based on the International Uveitis Study Group (IUSG) criteria.[30] The inflammation was defined as acute if symptoms were present for less than three months, chronic if symptoms were present for three months or more and recurrent if there were two or more episodes of inflammation separated by a disease-free period. Anterior and diffuse forms of uveitis were defined as granulomatous if large keratic precipitates or iris nodules were present. Laboratory and ancillary investigations were tailored for each patient as determined by history and physical findings at presentation.[31],[32],[33] Established diagnostic criteria were used for the confirmation of the etiological diagnosis.[34],[35],[36],[37],[38] The statistical analysis was performed using Chi-square test, t -test as appropriate. Mean age of individual diagnosis was compared with overall mean age (36.5 years) by t -test to analyze the differences in the age distribution in different diagnostic entities.

The total number of outpatients attending the hospital during the study period was 11,72,258. Of 11,72,258 patients, 9378 were found to have uveitis, accounting for 0.8% of the total outpatient visits. Of 9378, the records of 8759 uveitis patients were entered in a database for the analysis, 619 patients were excluded from the study because they failed to attend the follow-up visit. Of 8759 patients, 80.1% were from Tamil Nadu state and the remaining were from Kerala (10.1%) Andhra Pradesh (7.7%), Karnataka (0.3%), North Indian states (1.3%) and 46 were from outside India (0.5%). Demographic details are given in [Table - 1], mean age of the patients was 36.5 (±15.5) years (95% CI; 36.18 to 36.82 years). More than 60% of the patients were in the third to fifth decades, 7.0% of patients were 16 years of age or less and 7.3% of them were 60 years or above. Male, Female ratio of the uveitis patients (1.6:1) showed higher male predominance than the general ophthalmic patients in the same hospital (1.3:1, P < 0.05) seen in the same period of time.

Anterior uveitis was the commonest form of all uveitic entities (57.4%) followed by diffuse uveitis (22.4%), posterior uveitis (10.6%) and intermediate uveitis (9.5%) [Table - 2]. On the basis of overall clinical presentation, acute, unilateral and nongranulomatous forms occurred more frequently. However, acute presentation was more common in anterior and diffuse uveitis than intermediate and posterior uveitis, unilateral presentation was more common in anterior uveitis than in other types. Idiopathic uveitis constituted 44.6% of 8759 patients, followed by infectious (30.5%) and noninfectious etiologies (24.9%). Of 3909 (44.6%) idiopathic uveitis, 2246 (25.6%) were idiopathic anterior, 681 (7.8%) idiopathic intermediate, 339 (3.8%) idiopathic posterior and 643 (7.3%) idiopathic diffuse uveitis. Idiopathic entities were common in all age groups.

Etiological classifications in different age groups are given in [Table - 3]. Of 8759 patients, the predominant infectious uveitis included leptospirosis (9.7%), tuberculosis (5.6%) and herpetic disorders (4.9%). Noninfectious entities comprised Fuch's heterochoromic uveitis (4.8%), traumatic uveitis (4.4%), spondyloarthropathy (4.1%), sarcoidosis (4.0%) and lens protein uveitis (2.0%). Diagnoses were stratified according to the age groups and the results of the comparison of ages of individual diagnosis with the overall mean age (36.5 years) is given in [Table - 3],[Table - 4],[Table - 5],[Table - 6],[Table - 7]. Juvenile idiopathic arthritis, pediatric parasitic anterior uveitis, toxoplasmosis, endophthalmitis and leptospirosis occurred in the younger population while lens-induced uveitis, leprosy uveitis, sympathetic ophthalmia, herpetic anterior uveitis and sarcoidosis were more common in the elderly population ( P < 0.001).

The etiological subtypes in different anatomical locations are given in [Table - 4],[Table - 5],[Table - 6],[Table - 7]. In the anterior uveitis, pediatric parasitic anterior chamber granuloma (49.3%) and traumatic uveitis (9.8%) were predominant in the pediatric age group. While herpetic anterior uveitis (16.7%), lens-induced uveitis (14.6%) and leprosy uveitis (4.9%) were found more common in the elderly population. Fuch's heterochromic uveitis (9.8%), uveitis associated with spondyloarthropathy (8.2%), herpetic uveitis, (8.2%) and traumatic (7.8%) were equally common in middle-aged patients. [Table - 5] shows the distribution of intermediate uveitis. Causes were unknown in the majority of intermediate uveitis uniformly in all age groups.

Toxoplasmosis (23.5%) was the most common posterior uveitis entity in all the patients irrespective of the age group. Tuberculosis was the next common cause in children (10.4%) and in middle-aged patients (13.6%). Serpigenous choroiditis and sarcoidosis predominated in elderly patients (8%) [Table - 6]. The common diffuse uveitis [Table - 7] was endophthalmitis in the pediatric population (38.6%), leptospiral uveitis (29.7%) in middle age, leptospirosis, endophthalmitis and sympathetic ophthalmia (13.9%) in the elderly.


  Uveitis-Literature Review Top


Age and gender distribution

Uveitis affects young adults most commonly. In previous clinic-based surveys, roughly 60-80% of all patients were in the third through sixth decade of life with a mean age at presentation most often between 35 and 45 years of age. [1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23],[39] Uveitis was reported less frequently in children and in the elderly, with children constituting approximately 5-16%[40],[41],[42],[43] and the elderly accounting for 6-21.8% of cohorts.[10],[44],[45] Similar results were obtained from our survey, where 85.6% of patients were between 17 and 59 years of age and the mean age was 36.5 years. Pediatric and elderly patients in our cohort contributed to 7% and 7.3%, respectively.

With a few exceptions,[14],[21] most uveitis surveys from developed countries report either an equal gender distribution[8],[15],[16],[17],[23] or a slight predominance of women.[5],[9],[10],[11],[19] In studies from the United States, Europe and Japan, for example, women outnumbered men by 30% to 60%.[9],[10],[11],[19] In contrast, except a few[1],[2],[3] the surveys from developing countries, including two previous reports from India[5],[11],[12],[21],[23] described a male predominance of nearly 2:1. Similar results were observed in our cohort from South India. This difference was least pronounced in patients with intermediate uveitis, a disorder known to be particularly common in women, where the M:F ratio was 1.3:1 [Table - 1]. Factors contributing to such a clear male predominance in uveitis surveys reported from developing countries are undoubtedly complex. Consul and colleagues[23] have suggested that men tend to seek medical attention more often than women in agricultural societies and this may certainly have contributed to the trend in our clinic. Moreover, socioeconomic habits may put male patients at a greater risk of certain types of uveitis, particularly infectious forms such as leptospirosis[25],[26],[27],[28] and pediatric parasitic-induced granulomas,[29] which appear to affect men and boys disproportionately in South India where both disorders have been associated with exposure to contaminated water.

Primary location of inflammation

Most reports published to date have suggested that anterior uveitis is the most common form of intraocular inflammation.[1],[2],[3],[5],[6],[7],[9],[11],[13],[14],[15],[16],[17],[18],[20],[22] followed in turn by posterior, diffuse and intermediate uveitis.[7],[9],[11],[15],[18],[20] A few clinic-based surveys have, however, described diffuse[4],[8],[10] and posterior uveitis[4],[19],[21] as most common, a difference that may be attributed to referral bias, including the existence of a close collaboration with retina specialists in particular clinics. Diffuse uveitis was reported to be particularly common in Japan,[4],[10],[46] perhaps because of the high prevalence of Vogt-Koyanagi-Harada (VKH) disease, Behcet's syndrome and sarcoidosis, which often present with both anterior and posterior inflammation. Posterior and diffuse uveitis were remarkably common in reports from Africa, which could be attributed to a high incidence of infectious uveitis such as toxoplasmosis and onchocerciasis which affect mainly the posterior segment.[12],[21] A relatively low incidence of anterior uveitis in the South African population has also been assumed to be due to a low prevalence of the HLA-B27 halotype in that population.[12],[21] Anterior uveitis was the most common form of intraocular inflammation in our South Indian population, followed in turn by diffuse, post and intermediate uveitis. Biswas[11] from south India previously reported a higher frequency of posterior uveitis than diffuse, perhaps due to the relatively high frequency of toxoplasmosis and serpigenous choroiditis in their center.

Acute and chronic uveitis

Acute forms of uveitis tend to predominate in community-based hospitals[14] whereas chronic forms of uveitis tend to be more common in tertiary referral practices.[1],[9],[22] In one comparative study, for example, acute uveitis constituted 83.4% of community practices, but only 34.9% in a university practice.[14] Hence, the predominance of acute uveitis in our cohort most probably reflects the community-based care provided at present study. A higher frequency of infectious causes of anterior uveitis, such as leptospirosis and herpetic uveitis, may also have contributed to the preponderance of acute uveitis, however.

Unilateral and bilateral entities

While unilateral uveitis appears to be either equal or more common in both the developed[14],[22] and developing world,[1],[12] the etiologies in the two settings appear to differ dramatically. In the developed world the most common cause of unilateral involvement are uveitis associated with spondyloarthropathies,[4],[8],[9],[13],[14],[15],[16],[17],[18],[19],[20],[22] Fuch's heterochromic uveitis[7],[8],[9],[10],[11],[13],[15],[16],[20] and herpetic anterior uveitis.[7],[13],[14],[16],[17],[18] In contrast, the studies from the developing world, including the present report, include relatively high prevalence of traumatic uveitis,[11] herpetic[1],[2] toxoplasmosis,[23] lens-induced uveitis[5],[11],[23] parasitic pediatric anterior uveitis[29] and leptospirosis[25],[26],[27],[28] as important causes of unilateral inflammation. The bilateral uveitis is more common in some studies from the developed world[4],[9],[17] probably due to a high frequency of uveitis such as sarcoidosis[9] and Behcet's syndrome[17] which commonly affect both the eyes. While some of the bilateral entities like onchocerciasis are unique to certain geographical locations in the developing world,[47],[48],[49] the other specific bilateral entities seen in our population are VKH syndrome, sympathetic ophthalmia, serpigenous choroiditis and a proportion of leptospiral uveitis (31%).

Nongranulomatous and granulomatous uveitis

In general, nongranulomatous uveitis, which has been reported to constitute 51-89% of cases in previous series, occurs more often than granulomatous uveitis.[1],[9],[13] In the present study, 74% of our patients had nongranulomatous uveitis. The causes and frequency of common nongranulomatous uveitis varied widely in previous reports[1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23] but included uveitis associated with the sero-negative spondyloarthropathies (2-17.6%), Fuch's heterochromic uveitis (0.6-10%), traumatic uveitis (0.7- 8%), Juvenile Idiopathic Arthritis (JIA) (0.2-5.6%) and Behcet's syndrome (0.3-28%).[1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23] In contrast to previous reports, the most frequent nongranulomatous form of uveitis observed in our population was leptospirosis (9.7%). This was followed in turn by Fuch's heterochromic uveitis (4.8%), traumatic uveitis (4.4), the sero-negative spondyloarthropathies (4.1%) and Behcets syndrome (0.6%). The most common causes of granulomatous uveitis in previous studies from developed countries included sarcoidosis (0.5-18.1%), VKH disease (0.4-10%) and sympathetic ophthalmia (0.2-3.8%) while in developing countries, tuberculosis (0.2-30%)[3],[5],[11],[23] and leprosy[3],[11],[17] (0.2-1.2%) were noted in addition. The common causes of granulomatous uveitis observed in our population were tuberculosis (5.6%), sarcoidosis (4%), pediatric parasitic-induced uveitis (2.5%), VKH syndrome (1.4%), leprosy (1.2%) and sympathetic ophthalmia (0.8%). A significantly higher proportion of granulomatous uveitis was noted in children (38%) than in the middle-aged and elderly (14.8%) ( P < 0.001). This was mainly due to a higher prevalence of pediatric parasitic-induced uveitis (29.6%) in the pediatric subgroup.


  Etiology of Uveitis-Idiopathic Forms Top


For a sizable proportion of patients, the cause of uveitis remains unknown despite appropriate investigation, regardless of age, gender or anatomical location. Previous surveys have suggested that the cause of uveitis remains unknown in approximately 30-60% of patients[1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23] [Table - 8]. In general, anterior and intermediate uveitis is more often idiopathic than are posterior and diffuse forms of inflammation, and uveitis tends more often to be idiopathic in women as compared to men. In the present study, 44.6% of the total uveitis cohort and 47.8% of women had idiopathic uveitis.

Infectious uveitis - Developed world

Infectious uveitis accounted for relatively a minority of cases in most surveys reported from the developed world.[8],[9],[10],[14],[15],[16],[17],[18],[19],[20],[22] Toxoplasmosis was the single most common cause of infectious uveitis (3.8-17.7%) in most of these reports[5],[7],[8],[9],[13],[14],[15],[16],[17],[18],[19],[20],[22] followed by herpetic anterior uveitis[5],[6],[9],[13],[14],[16],[17],[18] (4.5-18.6%) and necrotizing herpetic retinitis[9],[13],[14],[15],[18],[19] (0.2-3.8%). Except a few,[4],[5],[7] tuberculosis[8],[9],[10],[15],[16],[17],[18],[19] and syphilis[8],[9],[14],[15],[16],[18],[19],[20],[22] appear to be rare causes of uveitis in developed countries, with a prevalence below 3%. Patients from rural areas had significantly higher frequency of infectious uveitis in a report from Poland. The explanation given by the author is significant human contact with animals and contaminated soil.[6] When we compare two reports from Japan, a more recent publication shows a marked increased frequency of systemic as well as ocular tuberculosis in Japan.[4],[10] Although minimal, a similar rise in tuberculosis is also seen in Netherlands.[15],[16]

Infectious uveitis - Developing world

Infectious uveitis occurs in greater frequency in the developing world, attributing from 11.9% to 50% of cases to infection [Table - 9]. The most common infectious forms of uveitis seen in developing countries include onchocerciasis,[47],[48],[49] toxoplasmosis[1],[3],[24] herpetic uveitis[1],[6],[12] tuberculosis,[3],[23] leprosy,[23] leptospirosis[25],[26],[27],[28] and other parasitic diseases.[29],[50] Onchocerciasis is common only in certain geographical areas in South America and Africa.[46],[47],[48],[49],[50] It accounted for 50 to 60% of blindness in Nigeria and formed the third cause of bilateral blindness in the Central African Republic.[46],[47],[48],[49] Infectious uveitis accounted for 35% of uveitis in one study from the Congo, Africa and included acquired immune deficiency syndrome (AIDS) (12.5%), herpes zoster (6.4%), toxoplasmosis (6.0%), tuberculosis (6.0%) and onchocerciasis[49] (4%). Toxoplasmosis was the second most important cause of uveitis (43%) after onchocerciasis in Sierra Leone, West Africa.[12] Similarly, in Brazil,[24] a population-based household survey revealed a higher prevalence of ocular toxoplasmosis (17.7%). A study from Saudi Arabia showed 36% cases to be infectious, with the most common being herpetic anterior uveitis (16%), tuberculosis (10.5%) and toxoplasmosis (6.5%).[5] A report from China claims a lower incidence of infectious uveitis including toxoplasmosis, however, authors declare a possibility of a bias because most of the infectious uveitis cases were handled at the retina clinic and also because of some posterior uveitis were grouped under a general heading of "fundus diseases" without a specific etiology.[2] Similar to our data, Yang from China reports absence of ocular histoplasmosis.[2]

An earlier Indian study reported a remarkably high prevalence of tuberculosis (30%), toxoplasmosis (7.2%), syphilis (5.4%) and leprosy (1.2%)[23] and in a latter one[11] from south India, infectious uveitis accounted for only 11.9% of cases and the predominant infection reported was toxoplasmosis (8%) followed by tuberculosis (0.6%) and herpetic anterior uveitis 5 (0.5%). However, a more recent study from North India shows tuberculosis and toxoplasmosis to be the commonest forms of infective uveitis.[3] In our present study, infections attributed to 30.7% of uveitis, the most common infectious forms in our population were leptospiral uveitis (9.7%) followed by tuberculosis (5.6%), herpetic anterior uveitis (4.9%), pediatric parasitic-induced anterior uveitis (2.5%) and toxoplasmosis (2.5%). The prevalence and types of infectious uveitis in our cohort further differed when causes were stratified according to the age groups. Infectious uveitis was more common in children, where the most common cause was pediatric parasitic anterior uveitis (29.6%), followed in turn by endophthalmitis (8%), leptospirosis (5.5%) and toxoplasmosis (4.7%). The occurrence of pediatric parasitic anterior uveitis in children appears to be a unique feature in this population.[29],[51] In middle-aged patients, the most common infectious cause was leptospiral uveitis (10.5%) followed by tuberculosis (5.9%) and herpetic anterior uveitis (4.5%). The high frequency of leptospiral uveitis in middle-aged patients is probably related to an increased exposure to contaminated water in this working age group.[27] In older patients, the most common infectious cause of uveitis was herpetic anterior uveitis (12.1%), followed by leprosy (3.6%) and leptospirosis (3.4%). The risk and prevalence of infectious uveitis in our cohort also varied considerably by anatomical location of the inflammation, infectious uveitis was more in posterior and diffuse forms ( P <0.005) than in anterior and intermediate forms in adults. However, herpetic uveitis and pediatric parasitic uveitis was the most frequent infectious anterior uveitis. As in several previous studies[1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[22],[23] toxoplasmosis was the most common posterior uveitis in our population as well, irrespective of age and gender. Leptospirosis was the predominant cause of diffuse uveitis.

Noninfectious uveitis

Epidemiological data suggest considerable variation in the frequency of noninfectious uveitis throughout the world depending upon the population studied. In general, the noninfectious uveitis syndromes are more common in developed countries, mainly because of lower prevalence rates of the various infectious forms of uveitis. Uveitis associated with the sero-negative spondyloarthropathy was the most common noninfectious entity (4-17.6%) in most of the studies,[2],[3],[4],[5],[8],[9],[11],[13],[14],[15],[16],[17],[18],[19],[20],[22] except in Japan[10] (2.5%) and Italy[7] (2.4%) where it was relatively rare. However, a more recent report from Japan[4] suggests an increased incidence of spondylopathy-associated uveitis. The second common noninfectious entity was sarcoidosis which accounted for 5-18.1% in the US, Netherlands and Japan.[4],[8],[9],[10],[13],[15],[16],[22] Sarcoidosis, however, appears to be rare in Italy[7] (0.8%), Israel[17] (0.5%), Portugal[18] (1.6%) and China (0.1%)[2]. The Behcet's syndrome is the leading cause in Turkey,[52] Saudi Arabia,[5] Israel,[17] China,[2],[53] Iran[54] and Japan[4],[10],[46] (6.5-28%) although there is a decline in the number of Behcet's in Japan in a recent report.[4] A study from North India highlights serpigenous choroidopathy as a leading cause of posterior uveitis and VKH syndrome and sympathetic ophthalmia more common non infectious panuveitis as in our present study.[3] In the present study, Fuch's heterochromic uveitis (4.8%), traumatic uveitis (4.4%), sero-negative spondyloarthropathy (4.1%) and sarcoid uveitis (4.0%) were found common, followed by lens-induced uveitis (2.0%), VKH syndrome (1.4%) and serpigenous choroidopathy (1.2%). A report from China[2] reveals a high proportion of Behcet's syndrome (16.5%), VKH syndrome (15.9%) and sympathetic ophthalmia (1.6 %) which are remarkably higher than all other reports. Like the present study, Yang from China reports absence of Bird shot retino choroidopathy in the Chinese population.[2] The prevalence of these noninfectious uveitis differed with age, however. In the literature, the commonest noninfectious uveitis in children is JIA[40],[41],[42],[43] whereas, in the elderly it appears to be sarcoidosis (8-20%) and sero-negative spondyloarthropathy[44],[45] (6-6.5%) In our population, traumatic uveitis and parsplanitis were more common in children (5.8%), whereas lens-induced uveitis (10.6%) was common in elderly patients.

We described the causes and characteristics of uveitis seen in a large, community-based eye hospital in South India. Infections accounted for nearly one-third of all cases of intraocular inflammation and included leptospiral uveitis, tuberculous uveitis and herpetic anterior uveitis. Etiologies varied with the age group of the patients. The most common cause of uveitis in children below 16 years of age was a recently described form of anterior chamber granuloma believed to result from infection by a parasite.[29],[51] The most common infectious cause in adults was leptospirosis. Leptospirosis, a zoonotic disease of global importance has been recognized as reemerging bacterial pathogens in India.[55],[56],[57],[58],[59],[60],[61],[62],[63] Probably because of the tropical climate and agricultural occupation, these differences are noted in this population.


  Conclusion Top


Changing patterns are seen in the studies from the same country done at different periods of time. [1],[2],[3],[4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17],[18],[19],[20],[21],[22],[23] A few such examples are, a decreased frequency of Behcet's disease and sarcoid with an increased frequency of tuberculosis have been noted in the studies from Japan.[4],[10],[46] Also, there is an increase in the incidence of spondyloarthropathy in Japan.[4],[10],[46] Again there is an upsurge in tuberculosis and serpigenous choroidopathy in India[3],[11],[23] and there is emergence of newer entities.[25],[26],[27],[28],[29] However, as stated by BenEzra,[40] the cause for the variable incidence of specific uveitic etiologies reported in different studies is also due to a "pattern changes in uveitis diagnosis". These pattern changes are because of a multitude of factors, including genetic, ethnic, geographic and environmental factors in addition to "changing pattern of uveitis" over the years. The best examples are from Africa. The pattern is entirely different in South and North Africa, onchocerciasis is common only in certain geographical areas in South Africa. Causes of uveitis vary considerably by geographic location around the world. Awareness of such regional differences in the disease pattern is essential in deriving a region-specific list of differential diagnoses and also in understanding the predictive values of diagnostic tests which in turn facilitate the final diagnosis.


  Acknowledgments Top


We sincerely thank Aravind Eye Care System for financial assistance, Emmett T. Cunningham, Jr, MD, PhD, MPH for his thought-provoking discussions and suggestions offered throughout this work. We extend our sincere thanks to Mrs. Shantheeswari and Mr. Karthik Prakash for meticulous data entry and data analysis.

 
  References Top

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    Tables

  [Table - 1], [Table - 2], [Table - 3], [Table - 4], [Table - 5], [Table - 6], [Table - 7], [Table - 8], [Table - 9]


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42 The association between vitamin D and uveitis: A comprehensive review
Shani Pillar, Radgonde Amer
Survey of Ophthalmology. 2021;
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43 Global prevalence and clinical outcomes of tubercular uveitis: a systematic review and meta-analysis
Hassan D. Alli, Naseer Ally, Ismail Mayet, Ziyaad Dangor, Shabir A Madhi
Survey of Ophthalmology. 2021;
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44 Diagnostic and therapeutic considerations in pediatric uveitis
Dimitrios Kalogeropoulos, Ioannis Asproudis, Maria Stefaniotou, Marilita Moschos, Robert Barry, Velota Sung, Sophia Tsabouri, Chris Kalogeropoulos
Spektrum der Augenheilkunde. 2021;
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45 Characteristics, evolution, and outcome of patients with non-infectious uveitis referred for rheumatologic assessment and management: an Egyptian multicenter retrospective study
Waleed A. Hassan, Basma M. Medhat, Maha M. Youssef, Yomna Farag, Noha Mostafa, Alshaimaa R. Alnaggar, Mervat E. Behiry, Rasha A. Abdel Noor, Riham S. H. M Allam
Clinical Rheumatology. 2021; 40(4): 1599
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46 Clinical features of childhood uveitis at a tertiary referral center in Southern Turkey
Ebru Esen, Selcuk Sizmaz, Sibel Balci, Rabia Miray Kisla Ekinci, Nihal Demircan
International Ophthalmology. 2021; 41(6): 2073
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47 Ocular manifestations of HLA B 27 associated uveitis: a study of 255 cases from a tertiary eye care centre from South India
Ruchika Lakra, Nandhini Elango, Amala Elizabeth George, Sudha K. Ganesh, Jyotirmay Biswas, Parthopratim Dutta Majumder
International Ophthalmology. 2021; 41(11): 3743
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48 Choroid vascularity index as a parameter for chronicity of Fuchs’ uveitis syndrome
Muhammet Derda Ozer, Muhammed Batur, Serek Tekin, Erbil Seven, Fatih Kebapci
International Ophthalmology. 2020; 40(6): 1429
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49 Spectral optical coherence tomography findings in patients with ocular toxoplasmosis: A case series study
Feriel Ammar, Ahmed Mahjoub, Nadia Ben Abdesslam, Leila Knani, Mohamed Ghorbel, Hachmi Mahjoub
Annals of Medicine and Surgery. 2020; 54: 125
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50 Relationship of Epiretinal Membrane Formation and Macular Edema Development in a Large Cohort of Uveitic Eyes
Debarshi Mustafi, Brian K. Do, Damien C. Rodger, Narsing A. Rao
Ocular Immunology and Inflammation. 2020; : 1
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51 Patterns of Uveitis in Egypt
Ahmed Abdelwareth Mohammed, Mahmoud Mohammed Soliman, Amr Abdellatif Osman, Radwa Taher El-Zanaty
Ocular Immunology and Inflammation. 2020; : 1
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52 Pediatric Uveitis and Scleritis in a Multi-Ethnic Asian Population
Samanthila Waduthantri, Soon-Phaik Chee
Ocular Immunology and Inflammation. 2020; : 1
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53 The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Descriptive Review of Tubercular Uveitis in Paediatric Population
Ilaria Testi, Rupesh Agrawal, Sarakshi Mahajan, Aniruddha Agarwal, Dinesh Visva Gunasekeran, Dhananjay Raje, Kanika Aggarwal, Somasheila I. Murthy, Mark Westcott, Soon-Phaik Chee, Peter Mccluskey, Su Ling Ho, Stephen Teoh, Luca Cimino, Jyotirmay Biswas, Shishir Narain, Manisha Agarwal, Padmamalini Mahendradas, Moncef Khairallah, Nicholas Jones, Ilknur Tugal-Tutkun, Kalpana Babu, Soumayava Basu, Ester Carreño, Richard Lee, Hassan Al-Dhibi, Bahram Bodaghi, Alessandro Invernizzi, Debra A. Goldstein, Carl P. Herbort, Talin Barisani-Asenbauer, Julio J González-López, Sofia Androudi, Reema Bansal, Bruttendu Moharana, Simona Degli Esposti, Anastasia Tasiopoulou, Sengal Nadarajah, Mamta Agarwal, Sharanaya Abraham, Ruchi Vala, Ramandeep Singh, Aman Sharma, Kusum Sharma, Manfred Zierhut, Onn Min Kon, Emmett T. Cunningham, John H. Kempen, Quan Dong Nguyen, Carlos Pavesio, Vishali Gupta
Ocular Immunology and Inflammation. 2020; : 1
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54 Risk factors for ocular complications in adult patients with uveitis
Mar Prieto-del-Cura, Juan Jacobo González-Guijarro
European Journal of Ophthalmology. 2020; 30(6): 1381
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55 Clinical utility of aqueous humor polymerase chain reaction and serologic testing for suspected infectious uveitis: a single-center retrospective study in South Korea
Wungrak Choi, Hyun Goo Kang, Eun Young Choi, Sung Soo Kim, Chan Yun Kim, Hyoung Jun Koh, Sung Chul Lee, Min Kim
BMC Ophthalmology. 2020; 20(1)
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56 Virus-associated anterior uveitis and secondary glaucoma: Diagnostics, clinical characteristics, and surgical options
Dominika Pohlmann, Milena Pahlitzsch, Stephan Schlickeiser, Sylvia Metzner, Matthias Lenglinger, Eckart Bertelmann, Anna-Karina B. Maier, Sibylle Winterhalter, Uwe Pleyer, Ahmed Awadein
PLOS ONE. 2020; 15(2): e0229260
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57 Incidence, prevalence, and risk factors of infectious uveitis and scleritis in the United States: A claims-based analysis
Youning Zhang, Sarina Amin, Khristina I. Lung, Seth Seabury, Narsing Rao, Brian C. Toy, I-Jong Wang
PLOS ONE. 2020; 15(8): e0237995
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58 Treatment of Cytomegalovirus Anterior Uveitis at a North American Tertiary Center With Oral Valganciclovir
Taniya Bhoopat, Jaskirat S. Takhar, Catherine E. Oldenburg, Jeremy D. Keenan, John A. Gonzales, Todd P. Margolis
Cornea. 2020; 39(5): 584
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59 The clinical profile and aetiological pattern of anterior uveitis- A hospital based study
Prathibha Shanthaveerappa, Nithisha Tegginamatha, Remya Parappallil
Indian Journal of Clinical and Experimental Ophthalmology. 2020; 6(1): 99
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60 Postoperative Complications of Manual Small Incision Cataract Surgery in Patients of Complicated Cataract with Uveitis in a Tertiary Health Care Centre in Western Odisha
Jagadish Prasad Rout, Pramod Kumar Sharma, Ruturaj Sahoo, Kulwant Lakra, Ravindra Kumar Chowdhury
Journal of Evidence Based Medicine and Healthcare. 2020; 7(38): 2087
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61 Protein Biomarkers in Uveitis
Reema Bansal, Amod Gupta
Frontiers in Immunology. 2020; 11
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62 Differential diagnosis of acute ocular pain: Teleophthalmology during COVID-19 pandemic - A perspective
SomasheilaI Murthy, Sujata Das, Parul Deshpande, Sushmita Kaushik, TarjaniVivek Dave, Prachi Agashe, Nupur Goel, Anuj Soni
Indian Journal of Ophthalmology. 2020; 68(7): 1371
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63 Tubulointerstitial nephritis and uveitis: The first report from the ophthalmology perspective in India
Gazal Patnaik, Parthopratim Dutta Majumder, Jyotirmay Biswas
Indian Journal of Ophthalmology. 2020; 68(9): 1993
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64 Commentary: Pattern of uveitis in a tertiary eye care center of central India: Results of a prospective patient database over a period of two years
Dipankar Das, Jyotirmay Biswas, Harsha Bhattacharjee
Indian Journal of Ophthalmology. 2020; 68(3): 482
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65 Pattern of uveitis in a tertiary eye care center of central India: Results of a prospective patient database over a period of two years
Prashant Borde, Priyanka, Kavita Kumar, Brijesh Takkar, Bhavana Sharma
Indian Journal of Ophthalmology. 2020; 68(3): 476
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66 Interleukins and cytokine biomarkers in uveitis
S Balamurugan, Dipankar Das, Murat Hasanreisoglu, BrianC Toy, Mashal Akhter, VK Anuradha, Eliza Anthony, Bharat Gurnani, Kirandeep Kaur
Indian Journal of Ophthalmology. 2020; 68(9): 1750
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67 Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study
Petra Svozilkova, Eva Rihova, Michaela Brichova, Andrea Havlikova, Aneta Klimova, Jarmila Heissigerova
Biomedical Papers. 2020; 164(4): 410
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68 Viral anterior uveitis
Kalpana Babu, VinayaKumar Konana, SudhaK Ganesh, Gazal Patnaik, NicoleS W Chan, Soon-Phaik Chee, Bianka Sobolewska, Manfred Zierhut
Indian Journal of Ophthalmology. 2020; 68(9): 1764
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69 Changing uveitis patterns in South India - Comparison between two decades
Jyotirmay Biswas, Ranju Kharel (Sitaula), Priyansha Multani
Indian Journal of Ophthalmology. 2018; 66(4): 524
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70 Changing patterns in uveitis South India: Comparison between two decades
ManoharBabu Balasundaram
Indian Journal of Ophthalmology. 2018; 66(4): 528
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71 Effects of Fuchs uveitis syndrome on the ultrastructure of the anterior lens epithelium: A transmission electron microscopic study
Kemal Tekin, YaseminOzdamar Erol, MustafaFevzi Sargon, Merve Inanc, PinarCakar Ozdal, Nilufer Berker
Indian Journal of Ophthalmology. 2017; 65(12): 1459
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72 Inflammatory choroidal neovascularization in Indian eyes: Etiology, clinical features, and outcomes to anti-vascular endothelial growth factor
Rupak Roy, Kumar Saurabh, Aditya Bansal, Amitabh Kumar, AnindyaKishore Majumdar, SwakshyarSaumya Paul
Indian Journal of Ophthalmology. 2017; 65(4): 295
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73 Unusual case of vitiligo reversal in Vogt–Koyanagi–Harada syndrome
Praveen Subudhi, Zahiruddin Khan, BNageswar Rao Subudhi, Silla Sitaram
Indian Journal of Ophthalmology. 2017; 65(9): 867
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74 PATTERN OF UVEITIS IN GHAZIABAD REGION OF DELHI NCR
Anshu Sharma, Sarita Aggarwal, Rimsha Thaseen, Rahul Sahay, Richa Ahluwalia
Journal of Evidence Based Medicine and Healthcare. 2017; 4(93): 5658
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75 Juvenile idiopathic arthritis-associated uveitis
Ethan S. Sen, A.V. Ramanan
Best Practice & Research Clinical Rheumatology. 2017; 31(4): 517
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76 Pigmentary disorders of the eyes and skin
Syril Keena T. Que,Gillian Weston,Jeanine Suchecki,Janelle Ricketts
Clinics in Dermatology. 2015; 33(2): 147
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77 The changing patterns of uveitis in a tertiary institute of Northeast India
Dipankar Das, Harsha Bhattacharjee, Kalyan Das, PreranaS Tahiliani, Pankaj Bhattacharyya, Gayatri Bharali, Manik Das, Apurba Deka, Rajashree Paul
Indian Journal of Ophthalmology. 2015; 63(9): 735
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78 Trends in Patterns of Posterior Uveitis and Panuveitis in a Tertiary Institution in Singapore
Helen Mi,Su L. Ho,Wee K. Lim,Elizabeth Py Wong,Stephen C. Teoh
Ocular Immunology and Inflammation. 2014; : 1
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79 Gender Differences in Ocular Blood Flow
Doreen Schmidl,Leopold Schmetterer,Gerhard Garhöfer,Alina Popa-Cherecheanu
Current Eye Research. 2014; : 1
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80 Autoimmune uveitis: a retrospective analysis of 104 patients from a tertiary reference center
Marcella Prete, Silvana Guerriero, Rosanna Dammacco, Maria Celeste Fatone, Angelo Vacca, Francesco Dammacco, Vito Racanelli
Journal of Ophthalmic Inflammation and Infection. 2014; 4(1)
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81 Tuberculous uveitis in China
Yu Mao,Xiao Yan Peng,Qi Sheng You,Hong Wang,Meng Zhao,Jost B. Jonas
Acta Ophthalmologica. 2014; : n/a
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82 FOCAL CHORIORETINITIS IN THAILAND
Kessara Pathanapitoon,Paradee Kunavisarut,Aniki Rothova
Retina. 2014; 34(3): 587
[Pubmed] | [DOI]
83 Prospective Head-to-Head Study Comparing 2 Commercial Interferon Gamma Release Assays for the Diagnosis of Tuberculous Uveitis
Marcus Ang,Wan Ling Wong,Sieh Yean Kiew,Xiang Li,Soon-Phaik Chee
American Journal of Ophthalmology. 2014; 157(6): 1306
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84 Topical tacrolimus nanoemulsion, a promising therapeutic approach for uveitis
Vaidehi Garg,Gaurav K. Jain,Jayabalan Nirmal,Kanchan Kohli
Medical Hypotheses. 2013; 81(5): 901
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85 Rheumatic Inflammatory Eye Diseases of Childhood
Andreas Reiff,Sibel Kadayifcilar,Seza Özen
Rheumatic Disease Clinics of North America. 2013; 39(4): 801
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86 Analysis of iris structure and iridocorneal angle parameters with anterior segment optical coherence tomography in Fuchs’ uveitis syndrome
Berna Basarir,Cigdem Altan,Eylem Yaman Pinarci,Ugur Celik,Banu Satana,Ahmet Demirok
International Ophthalmology. 2013; 33(3): 245
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87 Neoplastic Masquerade Syndromes among Uveitis Patients
Landon K. Grange,Amr Kouchouk,Monica D. Dalal,Susan Vitale,Robert B. Nussenblatt,Chi-Chao Chan,H. Nida Sen
American Journal of Ophthalmology. 2013;
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88 Herpesvirus detection and cytokine levels (IL-10, IL-6, and IFN-?) in ocular fluid from tunisian immunocompetent patients with uveitis
Imen Nahdi,Rym Ben Abdelwahed,Hannen Boukoum,Celine Bressollette-Bodin,Sonia Attia,Salim Ben Yahia,Sylvain Fisson,Moncef Khairallah,Mahjoub Aouni
Journal of Medical Virology. 2013; : n/a
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89 Review of Intermediate Uveitis
Frank H.P. Lai,David T.L. Liu,Dennis S.C. Lam
Asia-Pacific Journal of Ophthalmology. 2013; 2(6): 375
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90 Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry
John Baldwin, Paul J. Park, Brian Zanotti, Erika Maus, Michael V. Volin, Deepak Shukla, Vaibhav Tiwari
Journal of Virology. 2013; 87(7): 4091
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91 Interferon   release assay for the diagnosis of uveitis associated with tuberculosis: a Bayesian evaluation in the absence of a gold standard
M. Ang,W. L. Wong,X. Li,S.-P. Chee
British Journal of Ophthalmology. 2013; 97(8): 1062
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92 Trends in Patterns of Anterior Uveitis in a Tertiary Institution in Singapore
Wai Jia Tan,Eugenie W. Poh,Poh-Ying Wong,Su-Ling Ho,Wee-Kiak Lim,Stephen C. Teoh
Ocular Immunology and Inflammation. 2013; 21(4): 270
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93 Disease of the Year: Juvenile Idiopathic Arthritis—Differential Diagnosis
Sandra Hu-Torres,C. Stephen Foster
Ocular Immunology and Inflammation. 2013; : 1
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94 Clinical Profile of Isolated Viral Anterior Uveitis in a South Indian Patient Population
Kalpana Babu,Raghuvir Kini,Mariamma Philips,D. K. Subbakrishna
Ocular Immunology and Inflammation. 2013; : 1
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95 Spectrum of Fuchs Uveitic Syndrome in a North Indian Population
Manjari Tandon,Paavan Puneet Malhotra,Vishali Gupta,Amod Gupta,Aman Sharma
Ocular Immunology and Inflammation. 2012; 20(6): 429
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96 Evaluation of the Impact of Uveitis on Visual-related Quality of Life
Petrina Tan,Yan Tong Koh,Poh Ying Wong,Stephen C. Teoh
Ocular Immunology and Inflammation. 2012; 20(6): 453
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97 The Effect of Toll-Like Receptor 4 on Macrophage Cytokines During Endotoxin Induced Uveitis
Shuo Yang,Hong Lu,Jing Wang,Xin Qi,Xuhui Liu,Xiaolong Zhang
International Journal of Molecular Sciences. 2012; 13(12): 7508
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98 Clinical signs of uveitis associated with latent tuberculosis : Uveitis associated with tuberculosis
Marcus Ang, Alireza Hedayatfar, Rongli Zhang, Soon-Phaik Chee
Clinical and Experimental Ophthalmology. 2012; : no
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99 Leptospiral Uveitis - There Is More to It Than Meets the Eye!
A. Verma,B. Stevenson
Zoonoses and Public Health. 2012; 59: 132
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100 Viral causes of unexplained anterior uveitis in Thailand
N Kongyai, W Sirirungsi, K Pathanapitoon, N Tananuvat, P Kunavisarut, P Leechanachai, J D F de Groot-Mijnes, A Rothova
Eye. 2012;
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101 Intraocular tuberculosis
Reema Bansal,Aman Sharma,Amod Gupta
Expert Review of Ophthalmology. 2012; 7(4): 341
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102 Uveitis- a rare disease often associated with systemic diseases and infections- a systematic review of 2619 patients
Talin Barisani-Asenbauer,Saskia M Maca,Lamiss Mejdoubi,Wolfgang Emminger,Klaus Machold,Herbert Auer
Orphanet Journal of Rare Diseases. 2012; 7(1): 57
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103 Infectious causes of posterior uveitis and panuveitis in Thailand
Natedao Kongyai, Kessara Pathanapitoon, Wasna Sirirungsi, Paradee Kunavisarut, Jolanda D. F. Groot-Mijnes, Aniki Rothova
Japanese Journal of Ophthalmology. 2012;
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104 Epidemiology of Uveitis among the Chinese Population in Taiwan
De-Kuang Hwang,Yiing-Jeng Chou,Cheng-Yun Pu,Pesus Chou
Ophthalmology. 2012; 119(11): 2371
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105 Clinical Features, Investigations, Management, and Prognosis of Serpiginous Choroiditis
Radha Annamalai,Sridharan Sudharshan,Jyotirmay Biswas
Asia-Pacific Journal of Ophthalmology. 2012; 1(5): 287
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106 Comparison of Rubella Virus- and Herpes Virus-Associated Anterior Uveitis
Barbara Wensing, Lia M. Relvas, Laure E. Caspers, Natasa Vidovic Valentincic, Spela Stunf, Jolanda D.F. de Groot-Mijnes, Aniki Rothova
Ophthalmology. 2011;
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107 The diagnostic value of intraocular fluid analysis by polymerase chain reaction in Thai patients with uveitis
Kessara Pathanapitoon, Natedao Kongyai, Wasna Sirirungsi, Jolanda D.F. de Groot-Mijnes, Pranee Leechanachai, Janejit Choovuthayakorn, Paradee Kunavisarut, Aniki Rothova
Transactions of the Royal Society of Tropical Medicine and Hygiene. 2011;
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108 Uvéites antérieures
H. Zeghidi,P. LeHoang,B. Bodaghi
EMC - Ophtalmologie. 2011; 8(4): 1
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109 Intermediate uveitis in Indian population
Swapnil Parchand, Manjari Tandan, Vishali Gupta, Amod Gupta
Journal of Ophthalmic Inflammation and Infection. 2011;
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110 Population-based prevalence of uveitis in Southern India
Rathinam, S.R., Krishnadas, R., Ramakrishnan, R., Thulasiraj, R.D., Tielsch, J.M., Katz, J., Robin, A.L., Kempen, J.H.
British Journal of Ophthalmology. 2011; 95(4): 463-467
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111 Feature
Asia-Pacific Biotech News. 2011; 15(04): 10
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112 Viral anterior uveitis :
Aliza Jap, Soon-Phaik Chee
Current Opinion in Ophthalmology. 2011; 22(6): 483
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113 PREVALENCE, CLINICAL CHARACTERISTICS, AND CAUSES OF VISION LOSS IN CHILDREN WITH VOGT-KOYANAGI-HARADA DISEASE IN SOUTH INDIA :
Taliva D Martin, Sivakumar R Rathinam, Emmett T Cunningham
Retina. 2010; 30(7): 1113
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114 The Epidemiology of Uveitis in Developing Countries :
Nikolas J.S. London, Sivakumar R. Rathinam, Emmett T. Cunningham
International Ophthalmology Clinics. 2010; 50(2): 1-17
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115 Tuberculous Uveitis :
Ahmed M. Abu El-Asrar, Marwan Abouammoh, Hani S. Al-Mezaine
International Ophthalmology Clinics. 2010; 50(2): 19-39
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116 Leprosy Uveitis in the Developing World :
Sivakumar R. Rathinam
International Ophthalmology Clinics. 2010; 50(2): 99-111
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117 Leptospiral Uveitis in the Developing World :
Dhananjay Shukla, Sivakumar R. Rathinam, Emmett T. Cunningham
International Ophthalmology Clinics. 2010; 50(2): 113-124
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118 Uveitis: a global view
Emmett T Cunningham, Nikolas JS London, Sivakumar R Rathinam
Expert Review of Ophthalmology. 2010; 5(2): 113
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119 Uveitis in the developing world
Moncef Khairallah, Bechir Jelliti, Sonia Attia
Expert Review of Ophthalmology. 2010; 5(2): 161
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120 Patterns of Uveitis in Patients Admitted to a University Hospital in Riyadh, Saudi Arabia
Hani S. Al-Mezaine, Dustan Kangave, Ahmed M. Abu El-Asrar
Ocular Immunology and Inflammation. 2010; 18(6): 424
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121 Characteristics and predictors of recurrence of anterior and intermediate uveitis in a Canadian referral centre
Chan, S.M., Gan, K.D., Weis, E.
Canadian Journal of Ophthalmology. 2010; 45(2): 144-148
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122 Intermediate uveitis
Manohar, B.B., Rathinam, S.R.
Indian Journal of Ophthalmology. 2010; 58(1): 21-27
[Pubmed]
123 The causes of uveitis in a referral centre of Northern Italy
L. Cimino, R. Aldigeri, C. Salvarani, C. A. Zotti, L. Boiardi, M. Parmeggiani, B. Casali, L. Cappuccini
International Ophthalmology. 2010; 30(5): 521
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124 Clinical features and prognosis of herpetic anterior uveitis: a retrospective study of 111 cases
Ilknur Tugal-Tutkun, Berna Ötük-Yasar, Emre Altinkurt
International Ophthalmology. 2010; 30(5): 559
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125 Ocular sarcoidosis in Thailand
K Pathanapitoon, J H M Goossens, T C van Tilborg, P Kunavisarut, J Choovuthayakorn, A Rothova
Eye. 2010; 24(11): 1669
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126 Uveítis I. Clasificación. Exploración oftalmológica. Etiología. Aproximación diagnóstica. Complicaciones
F. Albarrán Hernández,A.I. Sánchez Atrio,A. Pérez Gómez,E. Cuende Quintana
Medicine - Programa de Formación Médica Continuada Acreditado. 2009; 10(32): 2145
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127 Infectious Uveitis in Children
Nikos N. Markomichelakis,Klio I. Chatzistefanou,Ioannis Papaefthymiou,Chryssanthi Koutsandrea,Tassos Kouris,Michael Apostolopoulos
Ophthalmology. 2009; 116(8): 1588
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128 Epidemiology and Course of Disease in Childhood Uveitis
Janine A. Smith,Friederike Mackensen,H. Nida Sen,Julie F. Leigh,Angela S. Watkins,Dmitry Pyatetsky,Howard H. Tessler,Robert B. Nussenblatt,James T. Rosenbaum,George F. Reed,Susan Vitale,Justine R. Smith,Debra A. Goldstein
Ophthalmology. 2009; 116(8): 1544
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129 A Cross-sectional and Longitudinal Study of Fuchs Uveitis Syndrome in Turkish Patients
Ilknur Tugal-Tutkun,Esra Güney-Tefekli,Fulya Kamaci-Duman,Isik Corum
American Journal of Ophthalmology. 2009; 148(4): 510
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130 Epidemiology and prevalence of uveitis: Review of literature
Chams, H., Rostami, M., Mohammadi, S.-F., Ohno, S.
Iranian Journal of Ophthalmology. 2009; 21(4): 4-16
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131 A Cross-sectional and Longitudinal Study of Fuchs Uveitis Syndrome in Turkish Patients
Tugal-Tutkun, I., Güney-Tefekli, E., Kamaci-Duman, F., Corum, I.
American Journal of Ophthalmology. 2009; 148(4): 510-515, e1
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132 Infectious Uveitis in Thailand: Serologic Analyses and Clinical Features
Sirirungsi, W. and Pathanapitoon, K. and Kongyai, N. and Weersink, A. and de Groot-Mijnes, J.D.F. and Leechanachai, P. and Ausayakhun, S. and Rothova, A.
Ocular Immunology \& Inflammation. 2009; 17(1): 17-22
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133 Pattern of uveitis in North East India: A tertiary eye care center study
Das, D. and Bhattacharjee, H. and Bhattacharyya, PK and Jain, L. and Panicker, MJ and Das, K. and Deka, AC
Indian Journal of Ophthalmology. 2009; 57(2): 144-146
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134 Infectious Uveitis in Children
Markomichelakis, N.N., Chatzistefanou, K.I., Papaefthymiou, I., Koutsandrea, C., Kouris, T., Apostolopoulos, M.
Ophthalmology. 2009; 116(8): 1588-1588,e2
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135 Epidemiology and Course of Disease in Childhood Uveitis
Smith, J.A., Mackensen, F., Sen, H.N., Leigh, J.F., Watkins, A.S., Pyatetsky, D., Tessler, H.H., (...), Goldstein, D.A.
Ophthalmology. 2009; 116(8): 1544-1551,e1
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136 Uveitis (I): Classification, ophthalmic exploration, etiology, diagnostic approach, complications | [Uveítis I. Clasificación. Exploración oftalmológica. Etiología. Aproximación diagnóstica. Complicaciones]
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Abstract
Uveitis-Literatu...
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