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Year : 2008  |  Volume : 56  |  Issue : 4  |  Page : 336-337

Neurotrophic keratitis in a patient with dihydroxypyrimidine dehydrogenase deficiency

Clayton Centre for Advanced Eye Specialties, Wakefield WF1 3JS, United Kingdom

Correspondence Address:
Bharat Kapoor
Clayton Hospital, Wakefield, WF1 3JS
United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.41422

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We describe a case of neurotrophic keratitis in association with dihydroxypyrimidine dehydrogenase (DHPD) deficiency. Ocular manifestations in patients with DHPD are rare and neurotrophic keratitis has never been reported before. A six-year-old boy who was a known case of DHPD deficiency and born of a consanguineous marriage presented to our clinic with non-healing corneal ulcers in both eyes. Reduced corneal sensations were detected and the patient was started on lubricating eye drops. The patient continues to be on lubricant eye drops and there has been no recurrence of the disease.

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