• Users Online: 3987
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 2008  |  Volume : 56  |  Issue : 5  |  Page : 377-383

Posterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome

Banker's Retina Clinic and Laser Centre, 5 Subhash Society, Behind Ishvar Bhuvan, Ahmedabad 380 009, India

Date of Submission08-Mar-2007
Date of Acceptance14-Feb-2008
Date of Web Publication8-Aug-2008

Correspondence Address:
Alay S Banker
Banker's Retina Clinic and Laser Centre, 5 Subhash Society, Behind Ishvar Bhuvan, Ahmedabad -380 009
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.42413

Rights and Permissions

Ocular manifestations can occur in up to 50% of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) patients and posterior segment involvement is the most common presentation. The posterior segment manifestations of AIDS can be divided into four categories: retinal vasculopathy, opportunistic infections, unusual malignancies and neuro-ophthalmologic abnormalities. Retinal microvasculopathy and cytomegalovirus (CMV) retinitis are the most common manifestations, even in the era of highly active anti-retroviral therapy (HAART). Highly active anti-retroviral therapy has been shown to cause regression of CMV retinitis, reduce the incidence of CMV-related retinal detachments, and prolong patient survival. Immune recovery uveitis is a new cause of vision loss in patients on HAART. Diagnosis and treatment are guided by the particular conditions and immune status of the patient.

Keywords: Acquired immune deficiency syndrome, cytomegalovirus retinitis, highly active antiretroviral therapy, immune recovery uveitis, microvasculopathy, posterior segment

How to cite this article:
Banker AS. Posterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome. Indian J Ophthalmol 2008;56:377-83

How to cite this URL:
Banker AS. Posterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome. Indian J Ophthalmol [serial online] 2008 [cited 2022 Oct 6];56:377-83. Available from: https://www.ijo.in/text.asp?2008/56/5/377/42413

As per the United Nations acquired immune deficiency syndrome (UNAIDS)/World Health organization (WHO) acquired immune deficiency syndrome (AIDS) epidemic update, December 2006, there are about 39.5 million (34.1–47.1 million) people globally living with human immunodeficiency virus (HIV). [1] Out of these, about 5.2–5.7 million people are from India. [2] In spite of the widespread use of highly active antiretroviral therapy (HAART) today, ocular manifestations of AIDS at some point affect 50 to 75% of infected persons, of which posterior segment involvement is the most common. [3] Also, the spectrum of ocular manifestations of AIDS in the developing world differs from that of developed nations. [4] The purpose of this article is to review all posterior segment manifestations of AIDS. The posterior segment manifestations in AIDS patients can be divided into four main categories: vasculopathy, opportunistic infections, unusual malignancies and neuro-ophthalmologic abnormalities.


Microvasculopathy is the most common ocular manifestation of AIDS, seen in about 40% to 60% of HIV-positive patients. [5] Clinically, it manifests as cotton-wool spots located in the posterior pole and may simulate small patches of cytomegalovirus (CMV) retinitis [Figure 1]. However, unlike CMV retinitis, cotton-wool spots are not associated with large amounts of hemorrhages, subtle iritis, or mild posterior vitritis. They have more rounded borders, and are usually oriented along the vascular arcades, and represent focal areas of ischemia in the nerve fiber layer. Most patients with retinal microvasculopathy are asymptomatic. Treatment is not indicated in most cases. The prevalence of microvasculopathy is inversely proportional to CD4+ count.

Large vessel disease

Large vessel occlusions, including central and branch retinal vein occlusions and branch retinal artery occlusions are uncommon and usually occur in association with viral retinitis, infiltrative lymphomatous optic neuropathy, and as isolated abnormalities. [6],[7],[8] Frosted branch vasculitis has been associated with CMV retinitis in AIDS. [9]

  Posterior segment opportunistic infections Top

Ocular posterior segment opportunistic infections are manifestations of disseminated disease in AIDS patients and are recognized either as necrotizing retinitis or as unifocal or multifocal choroiditis. Retinitis is more common than choroiditis. Retinitis in quiet eyes occurs in patients with lower CD4+ counts and is more commonly due to CMV and progressive outer retinal necrosis (PORN), while retinitis in inflamed eyes usually occur in patients with higher CD4+ counts and is more commonly due to acute retinal necrosis (ARN), toxoplasmosis, syphilis, or late stages of cryptococcus.

Cytomegalovirus retinitis

Cytomegalovirus retinitis is the most common AIDS-related ocular opportunistic infection and can develop in up to 40 to 50% of AIDS patients prior to HAART. [5] Although its incidence has declined markedly since the advent of HAART in the western world, it still remains the leading cause of ocular morbidity in the developing countries. [10] In India, CMV retinitis still remains the commonest ocular manifestation in AIDS cases. [11],[12] In our series of 1286 cases, the incidence of CMV retinitis remains high even in the era of HAART [Table 1]. It may be unilateral to start with, but up to 52% will eventually develop bilateral disease. Cytomegalovirus retinitis occurs almost exclusively in patients whose CD4+ counts are <50 cells/µl. [13] However, its diagnosis cannot be excluded based on CD4+ count alone in patients taking HAART. In exceptionally rare instances, CMV retinitis may develop in patients with elevated CD4+ counts shortly after the initiation of HAART.

Clinical findings : There are three clinical forms of CMV retinitis. The classical form (pizza pie retinopathy or cottage cheese with ketchup) is characterized by confluent retinal necrosis with hemorrhage that develops mostly in the posterior retina [Figure 2A]. The advancing edge of these lesions is usually very sharp and spreads contiguously. Typically, over several weeks untreated lesions progress to full-thickness necrosis with resultant retinal gliosis and pigment epithelial atrophy. Patients often have loss of visual field or visual acuity and scotoma. In contrast, the indolent form is recognized as a granular lesion in the peripheral retina, often with little or no hemorrhage [Figure 2B]. Patients may notice floaters, or they may be asymptomatic. A third uncommon presentation is frosted branch angiitis [Figure 2C]. Because approximately 15% of patients with active CMV retinitis are asymptomatic, routine screening with dilated indirect ophthalmoscopy has been recommended at three-month intervals in patients with CD4+ counts less than 50 cells/µl. [14] Cytomegalovirus retinitis may result in either serous or rhegmatogenous retinal detachment, although the latter is much more common. Rhegmatogenous retinal detachment has been reported in 13 to 29% of patients with CMV retinitis and may occur during the active or healed phase of the disease. However, since the advent of HAART, incidence of retinal detachment has decreased by approximately 60 to 77% in the western world. [15] In contrast, in our series, the incidence of CMV-related retinal detachment was found to have increased [Table 1]. This may be due to higher number of patients taking inappropriate HAART, or people taking HAART have larger areas of healed CMV retinitis which eventually develop necrotic holes leading to detachment. Various approaches including pars plana vitrectomy (PPV) with gas or silicone oil tamponade (preferably high viscosity 5000CS), scleral buckling and laser demarcation have been effective in the repair of retinal detachments related to CMV retinitis. [16]

Treatment : Treatment of CMV retinitis is individualized and depends upon the location of the active retinitis and the immune status of the patient. Currently available anti-CMV agents include ganciclovir and its prodrug valganciclovir, foscarnet, cidofovir, fomivirsen, ganciclovir implant and oral valganciclovir. A brief summary of these drugs is provided in [Table 2].

Necrotizing herpetic retinopathy

Necrotizing herpetic retinopathy (NHR) is a continuous spectrum of posterior segment inflammation induced by herpes viruses, most commonly varicella zoster virus (VZV). Its two most recognizable clinical patterns are ARN [Figure 3] and PORN [Figure 4]. Usually, the former occurs in healthy persons and AIDS patients with only mild immune dysfunction and elevated CD4+ counts, whereas the latter usually develops in those who are severely immunosuppressed. [17] In addition to varicella zoster virus, herpes simplex virus and CMV have been isolated in patients with ARN, and herpes simplex in eyes with PORN. [18] The differential features between ARN, PORN and CMV retinitis are given in [Table 3].

Aggressive medical treatment with appropriate systemic antivirals may improve long-term visual outcome in patients with NHR. Treatment of ARN includes intravenous acyclovir (1500 mg/sq, meter/day in three divided doses) for seven to 10 days followed by oral acyclovir (800 mg five times daily) for six weeks. [12] Following resolution of retinitis, prophylactic laser barrage is considered beneficial to prevent retinal detachment. However, visual loss due to progressive infection, optic nerve sheath effusion, or, in most cases, retinal detachment occurs in up to 70 to 85% of patients. Retinal detachment requires vitrectomy, intravitreal silicone oil tamponade and endolaser photocoagulation.


In the majority of AIDS cases, toxoplasmosis is a primary infection rather than a reactivation. Ocular toxoplasmosis in AIDS, in contrast to toxoplasmosis in immunocompetent individuals, is often bilateral, multifocal, and not associated with chorioretinal scars. It may cause a variety of ocular abnormalities including iritis, vitritis, choroiditis, multifocal or diffuse necrotizing retinitis [Figure 5], papillitis or retrobulbar neuritis, or outer retinal toxoplasmosis. [19] Toxoplasma retinitis may resemble CMV retinitis; however, intraocular inflammation is usually more severe and hemorrhages are fewer. Treatment with standard antiparasitic drugs (pyrimethamine, clindamycin, sulfonamides) is successful in controlling ocular toxoplasmosis in most cases.



Ocular manifestations of P. carinii include conjunctivitis, orbital mass, optic neuropathy, and choroiditis. [20] It is seen as classically bilateral and multifocal yellowish, well-demarcated, choroidal lesions located in the posterior pole not associated with vitritis, iritis, or vasculitis [Figure 6]. [21] Ocular lesions respond in most cases to induction and subsequent maintenance treatment with systemic pentamidine, trimethoprim and sulfamethoxazole, or dapsone.


Cryptococcus meningitis is the most common cause of AIDS-related neuro-ophthalmolgic lesions. Cryptococcal choroiditis may be multifocal, solitary, or confluent and may be associated with eyelid nodule, conjunctival mass, granulomatous iritis, iris mass, vitritis, necrotizing retinitis, endophthalmitis, and optic neuritis [Figure 7]. [22] Fluconazole maintenance therapy 200 mg/day is currently recommended in all patients even in the era of HAART.

  Ocular tuberculosis Top

Though pulmonary tuberculosis is the commonest systemic opportunistic infection seen in AIDS cases in India, the incidence of ocular tuberculosis is very low. In our study of 1286 cases, we found only 1% cases with presumed ocular tuberculosis. It usually presents as multifocal choroidal tubercles with discrete yellow lesions mainly at the posterior pole [Figure 8]. It may be associated with an exudative retinal detachment with variable vitreous inflammation. Occasionally, however, it may present as a big solitary posterior pole granuloma-like mass lesion [Figure 9]. [23] Treatment with long-term systemic anti-tuberculous drugs is effective in most cases. The spectrum of ocular tuberculosis, however, is changing in today's era of HAART. Recently, there has been a report of worsening of ocular tuberculosis in HIV patients after antiretroviral therapy. [24]

  Unusual malignancies Top

Reported posterior segment manifestations of non-Hodgkin's lymphoma (NHL) include necrotizing retinitis, multifocal choroiditis, retinal vasculitis, vitritis, subretinal mass, and pseudo-hypopyon uveitis. [25] Treatment options include radiation and chemotherapy.

  Neuro-ophthalmologic abnormalities Top

Neuro-ophthalmologic abnormalities usually are an indication of infection or lymphoma of the brain or meninges and occur in only 6% of AIDS patients. Clinical abnormalities of the optic nerve in a patient with AIDS may be recognized as perineuritis, papilledema, papillitis, retrobulbar neuritis, and optic atrophy. [26]

  Syphilis Top

Ocular syphilis in AIDS may present as iritis, vitritis, retrobulbar optic neuritis, perineuritis, papillitis, neuroretinitis, retinal vasculitis, a necrotizing retinitis which may be clinically indistinguishable from CMV and exudative retinal detachment. [27] Syphilis in AIDS may develop when CD4+ counts are greater than 200 cells/µl and, consequently, syphilis, including ocular syphilis, may be the presenting illness leading to the diagnosis of AIDS. It has been recommended that 12 to 24 million units of intravenous aqueous penicillin be administered for 10 days in AIDS patients with ocular syphilis.

  Ocular manifestations of HIV in the era of HAART Top

The advent of potent antiretroviral therapy has had a profound impact on the ophthalmological manifestations of AIDS patients. As these drugs lead to improved immune function, patients have fewer opportunistic infections. There have been reports of dramatic decreases in the frequency of CMV retinitis in areas where three- and four-drug antiretroviral combination therapies are routinely being used. In addition to decreased incidence, there are improved outcomes in patients with CMV retinitis who received new active antiretroviral therapy in addition to anti-CMV therapy. [28] In many patients with healed CMV retinitis who have responded to HAART, anti-CMV therapy has been discontinued without reactivation of the retinitis. In our study where combination antiretroviral treatment was given to 12 patients with active CMV retinitis, all anti-CMV medications were omitted once the CD4 cell counts were >100/mm 3 for three months. [29] The median CD4 cell count increased from 36.5/mm 3 (range, 3 to 74/mm 3 ) at baseline to 175.5/mm 3 (range, 97 to 410/mm 3 ) at three months. No patient had reactivation of CMV retinitis or development of extraocular CMV during median follow-up of 16.7 months. Although at present there are no standardized criteria for determining whether immunologic improvement is sufficient to allow withdrawal of therapy, a CD4+ cell count of at least 100 cells/mcL for at least three to six months, or a rise of at least 50 cells/mcL has been recommended. [30],[31] Reactivation of CMV retinitis has been reported in patients who discontinue or become intolerant to HAART. When maintenance therapy is discontinued, close observation is required.

Immune recovery uveitis

Immune recovery uveitis (IRU) is a noninfectious intraocular inflammation which develops in patients with inactive CMV retinitis who have had a substantial elevation in CD4+ count with HAART. Immune recovery uveitis is the leading cause of new visual loss in persons with AIDS seen in about 16 to 63% of HAART responders. The severity of the inflammation depends on the degree of immune reconstitution, extent of CMV retinitis, amount of intraocular CMV antigen, and previous treatment. Clinical findings include anterior chamber or vitreous reaction [Figure 10], panuveitis with hypopon, optic disk and cystoid macular edema, epiretinal membrane formation, cataract, vitreomacular traction syndrome, and proliferative vitreoretinopathy. [32],[33] Treatment with corticosteroids (subtenon or systemic or intravitreal) is effective in controlling inflammation and improving vision in some cases. However, surgery may be required in patients with vitreomacular traction syndrome, epiretinal membrane formation, cataract, and proliferative vitreoretinopathy.

  Summary Top

CMV retinitis is much less common in the era of HAART but remains one of the commonest ocular complications of AIDS in India. Highly active anti-retroviral therapy has been shown to cause regression of opportunistic infections, including CMV retinitis, increase time to relapse of CMV retinitis, reduce the incidence of CMV-related retinal detachments, and prolong patient survival. Patients with inactive CMV retinitis who have responded to HAART with a CD4+ cell count >100 cells/mcL for more than three to six months may be candidates for discontinuation of CMV maintenance therapy. Close follow-up for any signs of reactivation is mandatory. Immune recovery uveitis has been reported in patients with healed CMV retinitis who have responded to HAART. Necrotizing herpetic retinopathy and ocular tuberculosis are other common posterior segment disorders seen in AIDS cases.

  References Top

UNAIDS, AIDS epidemic update: Special report on HIV/AIDS: December 2006. Available from: http://data.unaids.org/pub/EpiReport/2006/2006_EpiUpdate_en.pdf. [last accessed on 2007 Oct 31].  Back to cited text no. 1
National AIDS Control Organization, Ministry of Health and family affairs, Government of India. HIV/AIDS epidemiological Surveillance and Estimation report for the year 2005. April 2006. Available from: http://www.nacoonline.org/fnlapil06rprt.pdf. [last accessed on 2007 Oct 31].  Back to cited text no. 2
Kestelyn PG, Cunningham Jr. ET. HIV/AIDS and blindness. Bull World Health Organ 2001;79:208-13.  Back to cited text no. 3
Vrabec TR. Posterior segment manifestations of HIV-AIDS. Surv Ophthalmol 2004;49:131-57.  Back to cited text no. 4
Jabs DA. Ocular manifestations of HIV infection. Trans Am Ophthalmol Soc 1995;93:623-83.  Back to cited text no. 5
Conway MD, Tong P, Olk RJ. Branch retinal artery occlusion (BRAO) combined with branch retinal vein occlusion (BRVO) and optic disc neovascularization associated with HIV and CMV retinitis. Int Ophthalmol 1996;19:249-52.  Back to cited text no. 6
Friedman SM, Margo CE. Bilateral central retinal vein occlusions in a patient with acquired immunodeficiency syndrome: Clinico-pathologic correlations. Arch Ophthalmol 1995;113:1184-8.  Back to cited text no. 7
Park KL, Marx JL, Lopez PF, Rao NA. Noninfectious branch retinal vein occlusion in HIV-positive patients. Retina 1997;17:162-4.  Back to cited text no. 8
Mansour AM, Li HK. Frosted retinal periphlebitis in the acquired immunodeficiency syndrome. Ophthalmologica 1993;207:182-6.  Back to cited text no. 9
Holbrook JT, Jabs DA, Weinberg DV, Lewis RA, Davis MD, Friedberg D, et al . Visual loss in patients with cytomegalovirus retinitis and acquired immunodeficiency syndrome before widespread availability of highly active antiretiroviral therapy. Arch Ophthalmol 2003;121:99-107.  Back to cited text no. 10
Biswas J, Madhavan HN, George AE, Kumarasamy N, Solomon S. Ocular lesions associated with HIV infection in India: A series of 100 consecutive patients evaluated at a referral center. Am J Ophthalmol 2000;129:9-15.  Back to cited text no. 11
Biswas J, Fogla R, Gopal L, Narayana KM, Banker AS, Kumarsamy N, et al . Current approaches to diagnosis and management of ocular lesions in human immunodeficiency virus positive patients. Indian J Ophthalmol 2002;50:83-96.  Back to cited text no. 12
[PUBMED]  Medknow Journal  
Kuppermann BD, Petty JG, Richman DD, Mathews WC, Fullerton SC, Rickman LS, et al . Correlation between CD4+ counts and prevalence of cytomegalovirus retinitis and human immunodeficiency virus-related noninfectious retinal vasculopathy in patients with acquired immunodeficiency syndrome. Am J Ophthalmol. 1993;115:575-82.  Back to cited text no. 13
Baldassano VF, Dunn JP, Feinberg J, Jabs DA. Cytomegalovirus retinitis and low CD4+ T-lymphocyte counts. N Engl J Med 1995;333:670.  Back to cited text no. 14
Cassoux N, Bodaghi B, Lautier-Frau M, Fardeau C, lehoang P. Current status of retinal detachment in AIDS patients. J Fr Ophtalmol 2000;23:1031-4.  Back to cited text no. 15
Freeman WR, Quiceno JI, Crapotta JA, Listhaus A, Munguia D, Aguilar MF. Surgical repair of rhegmatogenous retinal detachment in immunosuppressed patients with cytomegalovirus retinitis. Ophthalmology 1992;99:466-74.  Back to cited text no. 16
Guex-Crosier Y, Rochat C, Herbort CP. Necrotizing herpetic retinopathies: A spectrum of herpes virus-induced diseases determined by the immune state of the host. Ocul Immunol Inflamm 1997;5:259-65.  Back to cited text no. 17
Ormerod LD, Larkin JA, Margo CA, Pava PR, Menosky NM, Haight DO, et al . Rapidly progressive herpetic retinal necrosis: A blinding disease characteristic of advanced AIDS. Clin Infect Dis 1998;26:34-47.  Back to cited text no. 18
Holland GN, Engstrom RE Jr, Glasgow BJ, Berger BB, Daniels SA, Sidikaro Y, et al . Ocular toxoplasmosis in patients with the acquired immunodeficiency syndrome. Am J Ophthalmol 1988;106:653-67.  Back to cited text no. 19
Freeman WR, Gross JG, Labelle J, Oteken K, Katz B, Wiley CA. Pneumocystis carinii choroidopathy: A new clinical entity. Arch Ophthalmol 1989;107:863-7.  Back to cited text no. 20
Shami MJ, Freeman W, Friedberg D, Siderides E, Listhaus A, Ai E. A multicenter study of pneumocystis choroidopathy. Am J Ophthalmol 1991;112:15-22.  Back to cited text no. 21
Muccioli C, Belfort R, Neves R, Rao N. Limbal and choroidal Cryptococcus infection in the acquired immunodeficiency syndrome. Am J Ophthalmol 1995;120:539-40.  Back to cited text no. 22
Babu RB, Sudharshan S, Kumarasamy N, Therese L, Biswas J. Ocular tuberculosis in acquired immunodeficiency syndrome. Am J Ophthalmol 2006;142:413-8.  Back to cited text no. 23
Rathinam SR, Lalitha P. Paradoxical worsening of ocular tuberculosis in HIV patients after antiretroviral therapy. Eye 2007;21:667-8.  Back to cited text no. 24
Rivero ME, Kuppermann BD, Wiley CA, Garcia CR, Smith MD, Dreilinger A, et al . Acquired immunodeficiency syndrome-related intraocular B-cell lymphoma. Arch Ophthalmol 1999;117:616-22.  Back to cited text no. 25
Mansour AM. Neuro-ophthalmic findings in acquired immunodeficiency syndrome. J Clin Neuroophthalmol 1990;10:167-74.  Back to cited text no. 26
McLeish WM, Pulido JS, Holland S, Culbertson WW, Winward K. The ocular manifestations of syphilis in the human immunodeficiency virus type 1-infected host. Ophthalmology 1990;97:196-203.  Back to cited text no. 27
Reed JB, Schwab IR, Gordon J, Morse LS. Regression of cytomegalovirus retinitis associated with protease-inhibitor treatment in patients with AIDS. Am J Ophthalmol 1997;124:199-205.  Back to cited text no. 28
Banker AS, Patel A. Effect of combination antiretroviral therapy on cytomegalovirus retinitis. Indian J Opthalmol 2002;50:29-33.  Back to cited text no. 29
Vrabec TR, Baldassano VF, Whitcup SM. Discontinuation of maintenance therapy in patients with quiescent cytomegalovirus retinitis and elevated CD4+ counts. Ophthalmology 1998; 105:1259-64.  Back to cited text no. 30
Tural C, Romeu J, Sirera G, Andreu D, Conejero M, Ruiz S, et al . Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients. J Infect Dis 1998;177:1080-3.  Back to cited text no. 31
Karavellas MP, Azen SP, MacDonald JC, Shufelt CL, Lowder CY, Plummer DJ, et al . Immune recovery vitritis and uveitis in AIDS: Clinical predictors, sequelae and treatment outcomes. Retina 2001;21:1-9.  Back to cited text no. 32
Karavellas MP, Song M, McDonald JC, Freeman WR. Longterm posterior and anterior segment complications of immune recovery uveitis associated with cytomegalovirus retinitis. Am J Ophthalmol 2000;130:57-64.  Back to cited text no. 33


  [Figure 1], [Figure 2A], [Figure 2B], [Figure 2C], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8], [Figure 9], [Figure 10]

  [Table 1], [Table 2], [Table 3]

This article has been cited by
1 Vitreoretinal manifestations of human immunodeficiency virus infection and acquired immunodeficiency syndrome in patients attending an antiretroviral therapy clinic in Nigeria: A cross sectional study
YewandeO Babalola, TunjiS Oluleye, AdeyinkaO Ashaye
Journal of Clinical Sciences. 2022; 19(3): 73
[Pubmed] | [DOI]
2 Multimodal Imaging in AIDS-Related Ocular Cryptococcosis
Maria Fernanda Flores Herrera, Nicolas Dauby, Evelyne Maillart, Agnes Libois, Alberto Papaleo, Hind El Ouardighi, Laurence Postelmans, François Willermain, Dorine Makhoul, Alexander A. Bialasiewicz
Case Reports in Ophthalmological Medicine. 2021; 2021: 1
[Pubmed] | [DOI]
3 AIDS-related Cryptococcus neoformans choroiditis
Gregory S. Canfield, Sarah Reingold, Andrea Ho, Ann D. Thor, Paula E. Pecen, Kristen DeSanto, Daniel B. Chastain, Carlos Franco-Paredes, Jose R. Castillo-Mancilla, Andrés F. Henao-Martinez
IDCases. 2020; 22: e00931
[Pubmed] | [DOI]
4 HIV-induced Retinitis
Juliana Wons, John Kempen, Justus G. Garweg
Ocular Immunology and Inflammation. 2020; 28(8): 1259
[Pubmed] | [DOI]
Vishwanath Bannikuppe Narasimhaiah, Shruti Prakash Naik, Shashidhar Swamy, Lekha Lakshmikanth
Journal of Evidence Based Medicine and Healthcare. 2018; 5(28): 2134
[Pubmed] | [DOI]
6 Documento de Consenso de la Secretaría del Plan Nacional sobre el Sida/SEMES/GESIDA sobre urgencias y virus de la inmunodeficiencia humana
Enfermedades Infecciosas y Microbiología Clínica. 2013; 31(7): 455.e1
[Pubmed] | [DOI]
7 Ocular neuropathy in peripheral neuropathies
Ferhat Evliyaoglu,Remzi Karadag,Ahmet Z. Burakgazi
Muscle & Nerve. 2012; 46(5): 681
[Pubmed] | [DOI]
8 Cytomegalovirus retinitis associated with HIV in resource-constrained settings: systematic screening and case detection
Sophia Pathai,Stephen D. Lawn,Clare Gilbert
International Health. 2012; 4(2): 86
[Pubmed] | [DOI]
9 The Uncommon Combination of Common Variable Immunodeficiency, Macrophage Activation Syndrome, and Cytomegalovirus Retinitis
Asghar Aghamohammadi, Hassan Abolhassani, Armin Hirbod-Mobarakeh, Fariba Ghassemi, Shervin Shahinpour, Nasrin Behniafard, Ghazal Naghibzadeh, Amir Imanzadeh, Nima Rezaei
Viral Immunology. 2012; 25(2): 161
[VIEW] | [DOI]
10 Criptococosis ocular y retinitis por citomegalovirus en paciente inmunosuprimido
Catalina Montoya,Jose David Paulo,Luis Fernando Velásquez
Infectio. 2012; 16: 100
[Pubmed] | [DOI]
11 Evaluation of Ocular Manifestations and Blindness in HIV/AIDS Patients in a Tertiary Care Hospital in South India
Sunil Ganekal,Vishal Jhanji,Syril Dorairaj,Ashwini Nagarajappa
Ocular Immunology and Inflammation. 2012; 20(5): 336
[Pubmed] | [DOI]
12 Les complications oculaires au cours de l’infection par le VIH : expérience du pôle d’excellence Nord du Maroc
L. Lamzaf, W. Ammouri, O. Berbich, Z. Tazi Mezalek, M. Adnaoui, M. Aouni, H. Harmouche
Journal Français d Ophtalmologie. 2011; 34(2): 75
[VIEW] | [DOI]
13 Ocular complications of HIV infection: Experience of the Northern Excellence Pole of Morocco | [Les complications oculaires au cours de læinfection par le VIH: Expérience du pôle dæexcellence Nord du Maroc]
Lamzaf, L., Ammouri, W., Berbich, O., Tazi Mezalek, Z., Adnaoui, M., Aouni, M., Harmouche, H.
Journal Francais dæOphtalmologie. 2011; 34(2): 75-82
14 Ocular complications of drugs used in rheumatic disease
Tam, P., Taylor, S., Lightman, S.
Current Rheumatology Reviews. 2011; 7(1): 61-68
15 The clinical characteristics of cytomegaloviral retinitis in 19 cases with AIDS
Sun, H.-Y., Mao, F.-F., Li, D., He, H.-Y., Xu, X.-J., Liu, Y.-H., Chen, F.
Ophthalmology in China. 2010; 19(6): 376-379
16 Treatment and prevention of cytomegalovirus-associated diseases in HIV-1 infection in the era of HAART
Meyer-Olson, D., Schmidt, R.E., Bollmann, B.A.
HIV Therapy. 2010; 4(4): 413-436
17 Ocular lesions associated with human immunodeficiency virus infection
Upadhyay Col A.K., C.A.K., Vichare Maj N., M.N.
Medical Journal Armed Forces India. 2010; 66(3): 235-238
18 Ocular lesions associated with human immunodeficiency virus infection
AK Upadhyay, N Vichare
Medical Journal Armed Forces India. 2010; 66(3): 235
[VIEW] | [DOI]
19 Treatment and prevention of cytomegalovirus-associated diseases in HIV-1 infection in the era of HAART
Dirk Meyer-Olson,Reinhold E Schmidt,Benjamin A Bollmann
HIV Therapy. 2010; 4(4): 413
[Pubmed] | [DOI]
20 HIV/AIDS in the Developing World :
Nikolas J.S. London, Dhananjay Shukla, David Heiden, Sivakumar R. Rathinam, J. Fernando Arevalo, Emmett T. Cunningham
International Ophthalmology Clinics. 2010; 50(2): 201
[VIEW] | [DOI]
21 The Epidemiology of Uveitis in Developing Countries :
Nikolas J.S. London, Sivakumar R. Rathinam, Emmett T. Cunningham
International Ophthalmology Clinics. 2010; 50(2): 1
[VIEW] | [DOI]
22 Recent advances in drug delivery systems for treating ocular complications of systemic diseases
Susan S Lee, Patrick M Hughes, Michael R Robinson
Current Opinion in Ophthalmology. 2009; 20(6): 511-519
[Pubmed] | [DOI]
23 Intraocular penetration of antimicrobial agents in ophthalmic infections and drug delivery strategies
Velpandian, T.
Expert Opin. Drug Deliv.. 2009; 6(3): 255-270
24 Analysis of the ophthalmic opportunity infection of AIDS in 21 cases
Sun, H.-Y., Peng, X.-Y.
International Journal of Ophthalmology. 2009; 9(9): 1825-1826
25 HIV/AIDS and ocular complications
Tan, S.-Y., Liu, S.-W., Jiang, S.-B.
International Journal of Ophthalmology. 2009; 9(2): 203-213
26 Human immunodeficiency virus and the ophthalmologist
Soman, R., Purandare, B.
Indian Journal of Ophthalmology. 2008; 56(5): 355-356


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Posterior segmen...
Ocular tuberculosis
Unusual malignancies
Ocular manifesta...
Article Figures
Article Tables

 Article Access Statistics
    PDF Downloaded1149    
    Comments [Add]    
    Cited by others 26    

Recommend this journal