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Year : 2008  |  Volume : 56  |  Issue : 5  |  Page : 430-434

Familial unilateral Brown syndrome

1 St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, L7 8XP, United Kingdom
2 Institute of Medical Genetics, University Hospital of Wales, Cardiff, CF14 4XW, United Kingdom
3 Department of Ophthalmology, University Hospital of Wales, Cardiff, CF14 4XW, United Kingdom

Correspondence Address:
Patrick Watts
University Hospital of Wales, Heath Park, Cardiff, CF14 4XW
United Kingdom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0301-4738.42427

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We present a two-generation family with Brown syndrome. The proband was a six and a half-year-old female who presented with a history of failure of dextro-elevation of her left eye. A full ophthalmic evaluation was consistent with a left Brown syndrome. Family history revealed that her mother was operated on as a child for left Brown syndrome and examination of her four and a half-year-old sibling showed similar affection in the left eye. Autosomal dominant inheritance has been postulated in this condition. To our knowledge this is the first report of three members of a two-generation family with left-sided Brown syndrome. Genetic counseling of Brown syndrome cases is advised; nevertheless, identification of the responsible gene should shed more light on its genetics.

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