• Users Online: 96205
  • Home
  • Print this page
  • Email this page
SYMPOSIUM
Year : 2011  |  Volume : 59  |  Issue : 7  |  Page : 31-42

Complex genetic mechanisms in glaucoma: An overview


Kallam Anji Reddy Molecular Genetics Laboratory, Prof. Brien Holden Eye Research Centre, L.V. Prasad Eye Institute, Hyderabad, India

Correspondence Address:
Subhabrata Chakrabarti
Champalimaud Translational Centre, Prof. Brien Holden Eye Research Centre, L.V. Prasad Eye Institute, Banjara Hills, Hyderabad - 500 034
India
Login to access the Email id

Source of Support: Champalimaud Foundation, Portugal, and through a Program Support grant (BT/01/COE/06/02/10) from the Department of Biotechnology (DBT), Government of India, to SC, Conflict of Interest: None


DOI: 10.4103/0301-4738.73685

Rights and Permissions

Glaucomas comprise a group of hereditary optic neuropathies characterized by progressive and irreversible visual field loss and damage to the optic nerve head. It is a complex disease with multiple molecular mechanisms underlying its pathogenesis. Genetic heterogeneity is the hallmark of all glaucomas and multiple chromosomal loci have been linked to the disease, but only a few genes have been characterized, viz. myocilin (MYOC), optineurin (OPTN), WDR36 and neurotrophin-4 (NTF4) in primary open angle glaucoma (POAG) and CYP1B1 and LTBP2 in congenital and developmental glaucomas. Case-control-based association studies on candidate genes involved in different stages of glaucoma pathophysiology have indicated a very limited involvement. The complex mechanisms leading to glaucoma pathogenesis indicate that it could be attributed to multiple genes with varying magnitudes of effect. In this review, we provide an appraisal of the various efforts in unraveling the molecular mystery in glaucoma and also some future directions based on the available scientific knowledge and technological developments.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed7961    
    Printed219    
    Emailed11    
    PDF Downloaded859    
    Comments [Add]    
    Cited by others 15    

Recommend this journal