• Users Online: 4622
  • Home
  • Print this page
  • Email this page

   Table of Contents      
LETTER TO THE EDITOR
Year : 2014  |  Volume : 62  |  Issue : 12  |  Page : 1174

Comment on: Successful use of intravitreal and systemic colistin in treating multidrug resistant Pseudomonas aeruginosa postoperative endophthalmitis


1 Department of Ophthalmology, Konya Training and Research Hospital, Konya, Turkey
2 Department of Infectious Diseases and Clinical Microbiology, Konya State Hospital, Konya, Turkey

Date of Web Publication12-Jan-2015

Correspondence Address:
Dr. Muammer Ozcimen
Feritpasa Mah, Malazgirt Sok, Kardelen Apt. No: 14, Selcuklu, Konya
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.149152

Rights and Permissions

How to cite this article:
Ozcimen M, Sakarya Y, Sakarya R, Goktas S, Ozcimen S. Comment on: Successful use of intravitreal and systemic colistin in treating multidrug resistant Pseudomonas aeruginosa postoperative endophthalmitis. Indian J Ophthalmol 2014;62:1174

How to cite this URL:
Ozcimen M, Sakarya Y, Sakarya R, Goktas S, Ozcimen S. Comment on: Successful use of intravitreal and systemic colistin in treating multidrug resistant Pseudomonas aeruginosa postoperative endophthalmitis. Indian J Ophthalmol [serial online] 2014 [cited 2022 Oct 4];62:1174. Available from: https://www.ijo.in/text.asp?2014/62/12/1174/149152

Dear Editor,

We read with a great interest the article entitled "successful use of intravitreal and systemic colistin in treating multidrug resistant Pseudomonas aeruginosa postoperative endophthalmitis" by Samant and Ramugade. [1] They explored the efficacy of intravitreal and intravenous colistin in postoperative endophthalmitis; however, there are some points to be cleared out.

First, the dose of intravitreal dexamethasone in the study was 10-fold greater than the recommended dose regimen. Second, there are no safety studies of colistin when given intravitreally; therefore, there is no determined safe intravitreal dose of colistin. Third, it has been reported that colistin did not reach therapeutically relevant levels in the aqueous and in the vitreous humor of rabbit eyes. [2]

We wonder why the authors used such a high concentration of dexamethasone. The intravitreal dexamethasone dose should be 0.4 mg/0.1 ml instead of 4 mg/0.1 ml. [3] It would be informative if the authors explained how they found the dose of intravitreal colistin as 0.1 mg/0.1 ml. Finally, we argue that there should be a limited role for intravenously administered colistin in the treatment of Gram-negative bacterial endophthalmitis.

 
  References Top

1.
Samant P, Ramugade S. Successful use of intravitreal and systemic colistin in treating multidrug resistant Pseudomonas aeruginosa post-operative endophthalmitis. Indian J Ophthalmol 2014;62:1167-70.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Ozcimen M, Ozcimen S, Sakarya Y, Sakarya R, Goktas S, Alpfidan I, et al. Ocular penetration of intravenously administered colistin in rabbit uveitis model. J Ocul Pharmacol Ther 2014;30:681-5.  Back to cited text no. 2
    
3.
ESCRS Guidelines for Prevention and Treatment of Endophthalmitis Following Cataract Surgery: Data, Dilemmas and Conclusions; 2013.  Back to cited text no. 3
    




 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
References

 Article Access Statistics
    Viewed943    
    Printed17    
    Emailed0    
    PDF Downloaded202    
    Comments [Add]    

Recommend this journal