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BRIEF COMMUNICATION
Year : 2014  |  Volume : 62  |  Issue : 5  |  Page : 656-658

Hypertensive iridocyclitis associated with delayed onset biopsy proven Cytomegalovirus retinitis


1 Department of Ophthalmology, Greenlane Clinical Centre, Auckland, NewZealand
2 Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom
3 Department of Pathology, Royal Hallamshire Hospital, Sheffield, United Kingdom

Date of Submission24-Jun-2011
Date of Acceptance10-Apr-2012
Date of Web Publication30-May-2014

Correspondence Address:
Sudipto Bhatta
Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, S10 2JF
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.97086

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  Abstract 

We describe a case of primary hypertensive iridocyclitis with biopsy-proven Cytomegaloviral retinitis. It is an observational case report of a 69-year-old diabetic gentleman on azathioprine for Crohn's disease who presented with recurrent episodes of hypertensive iridocyclitis. On the 4 th attendance in 5 months, a granular white lesion was noted in the temporal periphery of the mid-peripheral fundus and a chorioretinal and vitreous biopsy performed. Vitreous PCR was positive for Cytomegalovirus (CMV). Hematoxylin and eosin staining revealed cytomegalic-like inclusions within necrotic neural retina. Transmission electron microscopy revealed herpes family virus particles and immunohistochemistry demonstrated CMV protein. This case provides further evidence implicating CMV infection in the etiology of hypertensive iridocyclitis. With hindsight, the cumulative effect of diabetes and azathioprine on the immune surveillance system proved sufficient to render the patient susceptible to CMV retinitis.

Keywords: Cytomegalovirus retinitis, hypertensive iridocyclitis, vitreous polymerace chain reaction


How to cite this article:
Squirrell DM, Bhatta S, Mudhar HS, Rennie IG. Hypertensive iridocyclitis associated with delayed onset biopsy proven Cytomegalovirus retinitis. Indian J Ophthalmol 2014;62:656-8

How to cite this URL:
Squirrell DM, Bhatta S, Mudhar HS, Rennie IG. Hypertensive iridocyclitis associated with delayed onset biopsy proven Cytomegalovirus retinitis. Indian J Ophthalmol [serial online] 2014 [cited 2024 Mar 28];62:656-8. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2014/62/5/656/97086

Posner-Schlossman syndrome (PSS) is recognized as a distinct clinical entity, comprising unilateral recurrent attacks of glaucoma where the intraocular pressure rise is out of proportion to the associated cyclitis. [1] Although it was initially hypothesized that PSS may have an allergic etiology, [1] more recently positive polymerace chain reaction (PCR) for Cytomegalovirus (CMV) has been described in anterior chamber isolates from immunocompetent individuals presenting with PSS. [2],[3],[4] These data suggest that at least in a subgroup of patients with presumed PSS, hypertensive iridocyclitis may actually be caused by a primary herpetic, particularly CMV infection of the eye, which individuals with a competent immune system limit to the anterior chamber. We describe the case of a 69-year-old diabetic gentleman who presented with recurrent episodes of hypertensive iridocyclitis mimicking PSS. On the fourth attendance in 5 months, a granular white lesion was noted in the temporal periphery of the mid peripheral fundus and a chorioretinal and vitreous biopsy performed. This revealed an unexpected diagnosis of CMV retinitis. We suggest that this case provides further evidence to implicate CMV infection of the eye as a causative trigger for hypertensive iridocyclitis, which in our case, went on to cause posterior segment disease. It also serves to emphasize the need to maintain a high index of suspicion for unusual infections when managing patients with compromised immune systems, from whatever cause.


  Case Report Top


A 69-year-old gentleman presented with a history of episodic blurred vision in his right eye. On examination, visual acuity was 6/12, the intraocular pressure was 48 mmHg, but aside a mild anterior chamber cellular reaction and fine stellate KPs, ocular examination was unremarkable. The patient's medical history included type 2 diabetes and terminal ileal Crohn's disease, for which he was prescribed Rosiglitazone and Azathioprine 150 mg od. There was no significant past ocular history.

A diagnosis of Posner-Schlossman Syndrome was made, and topical corticosteroids and timolol were prescribed. Following treatment, the ocular condition rapidly resolved with complete resolution of anterior chamber inflammation and normalization of IOP, but over the ensuing 3 months, the patient presented with 2 further episodes of presumed PSS. On each occasion, the condition was controlled with topical corticosteroids and timolol. On a further attendance 6 weeks later, the visual acuity was noticeably more reduced than previously (6/36), and in addition to a mild anterior chamber reaction and high intraocular pressure (42 mmHg), there was also a moderate vitritis. An examination of the posterior pole at this attendance revealed a small discrete area (2 disc diameters) of granular retinal pallor in the temporal periphery. There was no associated hemorrhage, and this was diagnosed as peripheral drusen. The patient was treated with topical and systemic prednisolone with resolution of the ocular inflammation and improved visual acuity. Over the ensuing 12 weeks, the systemic and topical steroids were tapered, but the ocular inflammation recurred as the dose was reduced. It was also noted that the previously noted white patch had enlarged [Figure 1] and a chorioretinal and vitreous biopsy organized. Vitreous PCR [LightCycler® FRET technology (Roche)] was positive for Cytomegalovirus (CMV) and negative for HZV, HSV 1 and 2. Hematoxylin and eosin staining revealed cytomegalic-like inclusions within necrotic neural retina. Transmission electron microscopy revealed herpes family virus particles, and immunohistochemistry demonstrated CMV protein [Figure 2]. The patient was investigated for other causes of immunocompromise without a positive result. In particular, 3 rd generation HIV test (ELISA) was negative, his CD4 counts were consistently above 350, and his full blood count was normal. Despite treatment with intravenous ganciclovir and long-term oral valcyclovir (as per local guidelines), the retinitis progressed rapidly to involve the central macula. The patient's final visual acuity was "hand movements".
Figure 1: Color fundus photograph. There is an area of granular retinal pallor in the temporal periphery, which had enlarged over 4 months. There is a possible satellite lesion at the fovea, an associated vitritis and new vessels at the disc

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Figure 2: Chorioretinal biopsy (a) Hematoxylin and eosin stained chorioretinal biopsy. The black arrows point to cytomegalic-like inclusions within the eosionophilic, necrotic neural retina (Magnification, ×400), (b) Immunohistochemistry: chorioretinal tissue stained with monoclonal antibodies to cytomegalovirus protein shows positive brown signal within the necrotic neural retina (Magnification, ×400), (c) Transmission electron microscopy shows herpes family viruses particles within the necrotic neural retina (Magnification, ×20000)

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  Discussion Top


Ocular CMV infection is most commonly known for the typical retinitis that is seen in those patients who are severely immunocompromised or receiving combination immunosuppressive therapy. [5] It is however recognized that CMV infection may also be implicated in PSS/ 'hypertensive iridocyclitis'. [3],[4] Currently, the pathophysiology of CMV associated hypertensive iridocyclitis remains obscure. [6] Anterior chamber involvement in patients with CMV retinitis secondary to AIDS is occasionally seen, but when present, is not typically a Posner-Schlossman like syndrome. The anterior chamber inflammation, observed in patients with AIDS, could be due to either primary anterior segment infection or it may also simply be an inflammatory response, secondary to posterior segment pathology.

The discovery of positive PCR for CMV in anterior chamber isolates from immunocompetent patients presenting with isolated PSS suggests that, at least in some patients, hypertensive iridocyclitis may actually be caused by primary herpetic infection of the anterior chamber and thus mimics PSS. [3],[4] With the benefit of hindsight, it is likely that in the case we describe the CMV infection was unrecognized for some months. The fact that the patient had a moderate vitritis also caused confusion as CMV retinitis is typically associated with a quiet vitreous. Only one can assume that the vitritis represented an inadequate immunological response to the virus, a response that is often not generated in patients with low CD4 counts associated with HIV CMV retinitis. Therefore, although the presentation of PSS in our patient predated the definitive diagnosis of CMV retinitis by 6 months, it is tempting to speculate that the initial presentation of PSS in our case also coincided with the primary presentation of CMV in the eye. Whilst not conclusive, we suggest that our case provides further evidence that CMV infection of the eye can present with a clinical syndrome of hypertensive iridocyclitis, which without further diagnostic testing, is indistinguishable from PSS. The evolving clinical scenario presented a number of diagnostic difficulties. With hindsight, the cumulative effect of diabetes and azathioprine on the immune surveillance system proved sufficient to render the patient susceptible to CMV retinitis. In patients without HIV, it is regrettably not unusual for the diagnosis of CMV retinitis to be delayed. [7] This case therefore also emphasizes the need to maintain a high index of suspicion for unusual infections when managing patients with compromised immune systems, from whatever cause.

 
  References Top

1.
Theodore FH. Observations on glaucomatocyclitic crises (Posner Schlossman syndrome). Br J Ophthalmol 1952;36:207-10.  Back to cited text no. 1
    
2.
Teoh SB, Thean L, Koay E. Cytomegalovirus in aetiology of Posner-Schlossman syndrome: Evidence from quantitative polymerase chain reaction. Eye (Lond) 2005;19:1338-40.  Back to cited text no. 2
    
3.
de Schryver I, Rozenberg F, Cassoux N, Michelson S, Kestelyn P, Lehoang P, et al. Diagnosis and treatment of cytomegalovirus iridocyclitis without retinal necrosis. Br J Ophthalmol 2006;90:852-5.  Back to cited text no. 3
    
4.
Chee SP, Bacsal K, Jap A, Se-Thoe SY, Cheng CL, Tan BH. Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients. Am J Ophthalmol 2008;145:834-40.   Back to cited text no. 4
    
5.
Yoser SL, Forster DJ, Rao NA. Systemic viral infections and their retinal and choroidal manifestations. Surv Ophthalmol 1993;37:312-52.  Back to cited text no. 5
    
6.
Kim EC, Moargolis TP. Hypertensive iridocyclitis. Br J Ophthalmol 2006;90:812-3.  Back to cited text no. 6
    
7.
Eid AJ, Bakri SJ, Kijpittayarit S, Razonable RR. Clinical features and outcomes of cytomegalovirus retinitis after transplantation. Transpl Infect Dis 2008;10:13-8.  Back to cited text no. 7
    


    Figures

  [Figure 1], [Figure 2]



 

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