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| LETTER TO THE EDITOR |
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| Year : 2015 | Volume
: 63
| Issue : 1 | Page : 82 |
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Vitamin D supplementation in antiphospholipid syndrome patients
N Venugopal
Neuro-ophthalmology Clinic, Glaucoma Service, AG Eye Hospital, Puthur, Trichy, Tamil Nadu, India
| Date of Web Publication | 16-Feb-2015 |
Correspondence Address:
N Venugopal
No. 19, Mathuram Apartments, Officer's Colony (Behind YMCA), Puthur, Trichy - 620 017, Tamil Nadu
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0301-4738.151497
How to cite this article:
Venugopal N. Vitamin D supplementation in antiphospholipid syndrome patients. Indian J Ophthalmol 2015;63:82 |
Sir,
Tugcu et al. [1] in their article titled "nonarteritic anterior ischemic optic neuropathy as the presenting manifestation of primary antiphospholipid syndrome (APS)" have stressed the importance of considering APS in the differential diagnosis of ischemic optic neuropathy, particularly when the etiology is uncertain. We appreciate author's effort and research work. Vitamine D deficiency [2] is common among APS patients and is associated with clinically defined thrombotic events. Hypovitaminosis D [3] probably may have a complex origin in APS and may be part of the mosaic of factors that contribute to autoimmunity, rather than a consequence of chronic disease and treatment. To conclude vitamine D deficiency (<10-20 ng/ml) and insufficiency (<30 ng/ml) should be corrected in all antiphospholipid antibody positive (aPL) patients [4] based on general population guidelines. The prognostic role of vitamine D deficiency and therapeutic value of supplementation (including the dosage and definition of treatment goals) in aPL positive patients should be clarified by prospective studies.
| References | |  |
| 1. | Tugcu B, Acar N, Coskun CT, Celik S, Yigit FU. Nonarteritic anterior ischemic optic neuropathy as the presenting manifestation of primary antiphospholipid syndrome. Indian J Ophthalmol 2014;62:642-4.  [ PUBMED]  |
| 2. | Agmon-Levin N, Blank M, Zandman-Goddard G, Orbach H, Meroni PL, Tincani A, et al. Vitamin D: An instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression. Ann Rheum Dis 2011;70:145-50. |
| 3. | Andreoli L, Piantoni S, Dall'Ara F, Allegri F, Meroni PL, Tincani A. Vitamin D and antiphospholipid syndrome. Lupus 2012;21:736-40. |
| 4. | Erkan D, Aguiar CL, Andrade D, Cohen H, Cuadrado MJ, Danowski A, et al. 14 th International Congress on Antiphospholipid Antibodies: Task force report on antiphospholipid syndrome treatment trends. Autoimmun Rev 2014;13:685-96. |
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