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ORIGINAL ARTICLE
Year : 2016  |  Volume : 64  |  Issue : 7  |  Page : 518-523

Coats' disease of adult-onset in 48 eyes


Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Chennai, Tamil Nadu, India

Date of Submission10-Jan-2014
Date of Acceptance19-Feb-2016
Date of Web Publication9-Sep-2016

Correspondence Address:
Pukhraj Rishi
Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18 College Road, Chennai - 600 006, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.190141

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  Abstract 

Background: Coats' disease diagnosed in adulthood is an idiopathic, retinal exudative vascular disease without an inciting factor and has retinal features different from the childhood disease. Aim: To describe clinical features, treatment, and outcomes of eyes with Coats' disease first diagnosed in patients 35 years or older. Materials and Methods: Retrospective chart review of patients first diagnosed with Coats' disease at the age of 35 years or more at a tertiary eye care center between January 1995 and 2012. Eyes with retinal exudation or Coats'-like response from secondary causes were excluded. Results: Forty-five of 646 patients (7%) diagnosed with Coats' disease had adult-onset disease. Mean age at presentation was 47 years. Systemic hypertension was the most common (22%) systemic association and decreased vision the predominant presenting feature (83%). Localized (<6 clock h) presentation (74%) was unique to adults as against diffuse involvement (69%) in children (P < 0.001). Eyes were treated with laser photocoagulation 29 (60%), cryotherapy (4%), or both (2%) with surgical intervention in three (6%) eyes. Following treatment eight (35%) eyes improved, 11 (48%) eyes were stable while four (12%) eyes worsened due to complications. Conclusion: Adult-onset Coats' disease has less extensive involvement, more benign natural course, and a more favorable treatment outcome as against the childhood-onset disease. The bilateral presentation emphasizes the need for regular follow-up to detect possible future involvement of the fellow eye.

Keywords: Adult, Coats′ disease, retina, retinal telangiectasia


How to cite this article:
Rishi E, Rishi P, Appukuttan B, Uparkar M, Sharma T, Gopal L. Coats' disease of adult-onset in 48 eyes. Indian J Ophthalmol 2016;64:518-23

How to cite this URL:
Rishi E, Rishi P, Appukuttan B, Uparkar M, Sharma T, Gopal L. Coats' disease of adult-onset in 48 eyes. Indian J Ophthalmol [serial online] 2016 [cited 2024 Mar 28];64:518-23. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2016/64/7/518/190141

The classic description of Coats' disease is reported among young male subjects and the disease diagnosed in adulthood is a rare entity. [1],[2],[3],[4] It is possible to detect a Coats'-like response in patients with ocular inflammation, infection, retinal degeneration, and postradiation therapy. However, a clear history and distinct clinical presentation help differentiate such patients from the "idiopathic" form of retinal exudation with telangiectasia that characterize Coats' disease. [5] Systemic conditions such as hypertension, diabetes mellitus, and hypercholesterolemia have been reported with adult-onset Coats' disease, [6] whereas no such association has been reported with the childhood-onset disease. Coats' disease diagnosed in adulthood is an idiopathic, retinal exudative vascular disease without an inciting factor and has retinal features different from the childhood disease [Figure 1]. [7],[8],[9],[10],[11],[12],[13] Vascular abnormalities are often present in both peripheral as well as juxtamacular areas and adults more commonly demonstrate localized lipid deposition, hemorrhage around macroaneurysms, and slower disease progression.
Figure 1: (a) Color fundus montage picture revealing telangiectasias in the temporal periphery with the presence of exudates and subretinal fluid. (b) Fundus fluorescein angiogram (arteriovenous phase) of the corresponding area depicting telangiectasias with typical light bulb appearance with areas of capillary nonperfusion

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There is very few information in the published literature about Coats' disease of adult-onset. Most of the reports exist in the form of isolated case reports or small case series. [6],[7],[8],[9],[10],[11],[14],[15],[16] We have earlier published our data of Coats' disease in 307 eyes, [12] and the present study aims to fill gaps in our current knowledge about Coats' disease of adults-onset in terms of disease presentation and treatment outcomes.


  Materials and Methods Top


A retrospective chart review of patients diagnosed with Coats' disease of adult-onset at a tertiary care center between January 1995 and January 2012 was carried out. All methods adhered to the tenets of the Declaration of Helsinki for research involving human subjects. As per the existing institutional policy at the time of the study, Ethics Committee clearance was not deemed necessary at our institute in view of the retrospective nature of the study. Patients first diagnosed with Coats' disease at 35 years of age or more were included. This criterion was based on our previous series on Coats' disease with a bimodal peak of presentation, the second peak being beyond 35 years of age. Supposedly, this approach would also help decrease the possibility of including cases that actually began during childhood or adolescence. Six hundred and forty-six patients were diagnosed with Coats' disease. Among these, 45 patients (48 eyes) had Coats' disease of adult-onset. A complete history with special attention to systemic disease (systemic hypertension, diabetes mellitus, dyslipidemia, etc.,) was elicited.

Clinical parameters which were evaluated included best-corrected visual acuity, intraocular pressure (IOP), and anterior and posterior segment features. Coats' disease was diagnosed if an eye had idiopathic retinal telangiectasia with or without intra- or sub-retinal exudation. Retinal telangiectasia was defined as abnormal dilatation of the terminal precapillary vessels often present in clusters and possibly associated with exudation or subretinal fluid. Retinal exudation was defined as discrete yellow subretinal/intraretinal deposits with sharp edges. We excluded patients with secondary causes of exudation and telangiectasia such as radiation retinopathy, retinal vascular occlusions, postinflammatory causes, and retinal capillary hemangioblastoma.

The disease extent was classified into three zones, the macula (area between the temporal vascular arcades) being zone 1, the mid-periphery, between the retinal vascular arcades and equator being zone 2, and the peripheral fundus anterior to this being zone 3. Staging of the disease was done based on the extent and the quadrant (s) of retina involved according to classification by Shields et al. [2] Fundus fluorescein angiography confirmed active telangiectatic leakage, areas of capillary nonperfusion, and also helped rule out other differential diagnosis. Optical coherence tomography (OCT) was done in selected eyes depending on physician discretion. Ultrasound B-scan was performed when extensive bullous retinal detachment with exudation resulted in a diagnostic dilemma.

Treatment was advised if deemed necessary by the treating physician. Laser photocoagulation or cryotherapy was done to the leaking vascular lesions. Vitrectomy or scleral buckling along with laser photocoagulation or cryotherapy to the leaking areas was done for patients with rhegmatogenous or tractional retinal detachment. Operated patients were followed up on the first postoperative day, 1 st week, 6 weeks, 6 months, and at 1 year. Patients in the observation group were followed up at 6 monthly intervals. At each follow-up, visual acuity (Snellen's chart), IOP, presence or absence of neovascular changes in the iris or angle, and fundus evaluation for disease progression were carried out.

Visual improvement and worsening were defined as gain or loss of two or more lines on Snellen's chart while vision change <2 Snellen's lines was considered as stabilization of visual acuity. The Snellen's visual acuity was converted to logarithm of the minimum angle of resolution (logMAR) for the ease of statistical analysis. The resolution of telangiectasia, retinal exudation, status of the retina (attached or detached), and presence or absence of complications like neovascular glaucoma were determined. Based on follow-up examinations, the final ocular outcome (improved, stable, or worse) was assessed. Statistical analysis was done using parametric and nonparametric tests of significance to look for differences between presentations of adult-onset and childhood-onset Coats' disease and also for the difference between adult-onset Coats' disease in Indian and the Western counterparts. The SPSS version 13.0 (SPSS Science, Chicago, IL, USA) was used for statistical analysis.


  Results Top


Between January 1995 and January 2012, 45 of 646 (7%) patients presenting at 35 years of age or above were diagnosed of Coats' disease, with 33 (73%) being males. The mean age at presentation was 47 years (range: 35-70 years). Systemic hypertension was the most common associated systemic condition in ten (22%) patients [Table 1]. Forty-two (93%) patients had unilateral presentation [Table 1] with diminution of vision being the most common presenting complaint in forty (83.3%) patients. Incidental diagnosis of Coats' disease was made in four (8%) patients [Table 2]a. The average duration of complaint (s) was 14 months (range: 10 days to 5 years). Family history was negative in all cases. Visual acuity recorded with Snellen's chart was converted to logMAR for ease of evaluation. Mean logMAR visual acuity was 1.13 ± 0.91. Eighteen eyes (38%) had visual acuity of 20/60 (logMAR 0.47) or better [Table 2]a. Eighteen eyes (38%) had vision between 20/80 and 20/200 (logMAR 0.6-1), and 12 eyes (25%) had visual acuity worse than 20/200 (logMAR 1); three eyes had only light perception (LP) vision. Myopia was an ocular association in five (10%) eyes, whereas lattice degeneration was seen in two (4%) eyes. Anterior segment evaluation revealed the presence of a cataract in 13 (29%) eyes, exotropia in three (6%) eyes, and neovascular glaucoma in one (2%) eye. Details of fundus examination and the staging of Coats' disease are presented in [Table 2]b and c. Features of OCT are summarized in [Table 2]d. None of the eyes showed the presence of vasoproliferative tumor.
Table 1: Coats' disease of adult - onset in 48 eyes patient demographics

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Table 2:

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Thirty-five (73%) eyes underwent treatment [Table 3] while 13 (27%) were observed. Laser photocoagulation to the telangiectatic vessels was the most common treatment modality used in 29 (60%) eyes. A single session of laser was adequate in 25 patients; two sessions in five patients and up to four sessions were required in two eyes. The pre- and post-treatment visual acuity of patients treated with a laser is depicted in [Figure 2]. Eleven (23%) eyes presented with retinal detachment; five with total retinal detachment and six had subtotal detachment. Two eyes with total rhegmatogenous retinal detachment underwent surgical repair. Three eyes with long-standing detachment and atrophic retina were observed in view of the poor visual potential. Of the two patients, one was lost to follow-up after surgery. The other patient had a recent-onset total retinal detachment and was managed with scleral buckling plus vitrectomy and silicone oil endotamponade. He maintained a vision of 6/36 in this eye at 4 years of follow-up.
Figure 2: Bar diagram depicting the pre- and post-treatment visual acuity of eyes treated with laser photocoagulation

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Table 3: Differences in the management of adult, pediatric, and Western subjects with Coats' disease

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Subtotal retinal detachment was seen in six (13%) eyes (three eyes each with stage 3A1 and 3A2). Of these, four eyes underwent laser photocoagulation to telangiectatic vessels. Among four eyes subjected to laser photocoagulation, two eyes showed improvement in visual acuity, one maintained same vision, while one was lost to follow-up. The remaining two eyes with retinal detachment required surgical intervention; one eye had vitrectomy with scleral buckling for nonresolving vitreous hemorrhage and tractional retinal detachment. This patient developed cataract and underwent phacoemulsification with intraocular lens implantation after 1½ years. His retinal condition and vision remained stable at the last follow-up. The second patient was treated with laser photocoagulation and encirclage for exudative retinal detachment and vitreoretinal traction. This patient was lost to follow-up after 2 months.

The mean follow-up of patients was 40 months (range: 1-122 months). Thirty-two (67%) eyes had a follow-up of more than 6 months. Of these, 23 (48%) eyes were treated and nine (15%) eyes were observed. A favorable structural outcome in the form of reduced exudation was seen in 13 (57%) treated eyes versus three (33%) untreated eyes [Table 4]. With respect to the visual outcome, four (12%) eyes worsened due to the presence of multiple complications such as glaucoma, disc pallor, recurrent retinal detachment, persistent macular edema, and macular scarring [Figure 3]. It was decided to observe the eyes not amenable to treatment, eight (88%) such eyes maintained vision, one (11%) worsened but none of them improved. Glaucoma was the most common complication in four (8%) eyes, three eyes developed secondary angle closure in treated group, and one eye developed neovascular glaucoma in the untreated group. Retinal detachment was seen in two eyes and vitreous hemorrhage in one eye. None of the eyes progressed to painful blind eye necessitating enucleation.
Figure 3: (a) Diffuse retinal thickness with subfoveal fluid (b) following treatment foveal thickness reduced with a resolution of fluid and subretinal scarring (c) near normal macula at presentation (d) lamellar macular hole and chronic cystoid changes developed despite laser to peripheral lesions. (e) Diffuse and spongiform retinal thickness with massive schitic changes (f) line scan through telangiectatic vessel shows area of signal void with shadowing (g) subfoveal scarring and adjacent diffuse retinal thickening (h) line scan through organized retinal exudation reveals increased retinal thickening with shadowing and back-scattering

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Table 4: Difference in outcomes between treated and untreated eyes with adult-onset Coats' disease at final follow-up

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A comparative analysis of the presenting features between the childhood [12] and adult-onset Coats' disease was done and also compared to the published literature [Table 2]. [6] Adult-onset Coats' disease was found to have more localized presentation with 36 (74%) eyes having ≤2 quadrant of involvement. Comparing the treatment and outcomes [Table 3], more adults were treatable with laser (60% vs. 27%, P < 0.001) and surgery was required in only three eyes (6% vs. 26%, P < 0.003). None of the eyes required enucleation (0 vs. 10%) when compared with the pediatric series. Visual outcomes in published literature were significantly better than the current series as the presenting visual acuity was better to begin with (69% vs. 38%, P = 0.04) [Table 2].


  Discussion Top


Coats' disease is a disease typically seen in childhood and less commonly among adults. [6] Bilaterality (7% vs. 0%) and increased female affection (27% vs. 7%) were noticeable in our series [Table 1] than in the published literature. [16] Decreased vision was the most common presenting complaint (83%) probably due to more prevalent macular involvement in our subjects. Our series, as well as published literature, show that leukocoria is never a presenting feature in adults as the disease is never that extensive and also probably due to earlier diagnosis in adults as compared to children. Systemic associations observed in our series were similar to the series by Smithen et al.[6] with systemic hypertension being the most common followed by diabetes mellitus and hypercholesterolemia [Table 1]. Anterior segment abnormalities like cataract, exotropia, and neovascular glaucoma were unique to our series and not reported by Smithen et al. [6] Hemorrhage was seen in fewer eyes in our series (18% vs. 77%). Preretinal and subretinal hemorrhages were commonly noted and vitreous hemorrhage was an unusual presenting feature noted in the current series. It has been postulated by Tripathi and Ashton [13] that retinal capillary nonperfusion, vessel wall changes, breakdown of the blood-retinal barrier could be the causes for hemorrhage from microaneurysms or macroaneurysms.

The presence of <2 quadrant involvement in adults as against the diffuse involvement in the childhood disease [Table 2]c probably explains why the disease is milder with slower progression in adults as against the childhood-onset disease, which is known to be rapidly progressive, often presenting with end-stage complications such as total retinal detachment or neovascular glaucoma leading to phthisis bulbi or painful blind eye. [6],[12] Although not statistically significant, the results are very encouraging when compared with the outcome of treatment in the classic childhood disease. Neovascular glaucoma, a dreaded complication of untreated childhood Coats' disease, [3],[12] was seen in only one of the adult patients in this series. The few older adults in the series by Shields et al. [3] had findings identical to the children in that series, and they had no other underlying conditions to predispose to exudative retinopathy.

Exudative retinal detachment in our series responded to laser or cryotherapy similar to series by Smithen et al. [6] where all four patients responded well to laser. Three patients in our series necessitated surgical intervention due to the development of breaks/traction at the site of telangiectasia. None of the patients required surgical intervention in the series by Smithen et al. Antivascular endothelial growth factor (VEGF) has also been tried in several cases as an adjunct to treatment modalities like laser and cryotherapy. [10] However, Ramasubramanian and Shields [17] have advised caution in the use of anti-VEGF as they observed vitreoretinal traction and progressive tractional detachment in their series. Anti-VEGF was not used in any of our patients. In our series, loss of vision was mainly attributable to factors such as glaucoma (secondary angle closure), disc pallor, recurrent retinal detachment, persistent macular edema, and macular scarring, whereas Smithen et al. [6] observed persistent macular edema, epiretinal membrane, and foveal ischemia as the causes for visual loss.

Distinct features in our series included bilateral presentation, presence of anterior segment changes (cataract and exotropia), more frequent macular involvement, vitreous hemorrhage, relatively poor visual acuity at presentation, and exudative retinal detachment with associated tractional or rhegmatogenous component necessitating surgical intervention. Genetic and other demographic factors may underlie these differences. We did not have a genetic workup done in any of our cases. Larger studies with a comprehensive genetic workup may reveal these disparities.


  Conclusion Top


Just like the childhood-onset disease, retinal exudation and telangiectasia remain the hallmarks for diagnosis in adult-onset Coats' disease too, though with less extensive involvement, more benign natural course and a more favorable treatment outcome. Disease progression and possible bilateral affection underscores the need for long-term follow-up.

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Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

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Jarin RR, Teoh SC, Lim TH. Resolution of severe macular oedema in adult Coat's syndrome with high-dose intravitreal triamcinolone acetonide. Eye (Lond) 2006;20:163-5.  Back to cited text no. 7
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Vázquez-Pulido N, Laliena Santamaría JL, Del Buey Sayas MA, Burdeus Gómez R, Osan Tello M. Adult-onset of recurrent Coats disease. Arch Soc Esp Oftalmol 2007;82:555-8.  Back to cited text no. 8
    
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Jun JH, Kim YC, Kim KS. Resolution of severe macular edema in adult Coats' disease with intravitreal triamcinolone and bevacizumab injection. Korean J Ophthalmol 2008;22:190-3.  Back to cited text no. 9
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Beselga D, Campos A, Mendes S, Carvalheira F, Castro M, Castanheira D. Refractory Coats' disease of adult onset. Case Rep Ophthalmol 2012;3:118-22.  Back to cited text no. 11
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Rishi P, Rishi E, Uparkar M, Sharma T, Gopal L, Bhende P, et al. Coats' disease: An Indian perspective. Indian J Ophthalmol 2010;58:119-24.  Back to cited text no. 12
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Tripathi R, Ashton N. Electron microscopical study of Coat's disease. Br J Ophthalmol 1971;55:289-301.  Back to cited text no. 13
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Otani T, Yasuda K, Aizawa N, Sakai F, Nakazawa T, Shimura M. Over 10 years follow-up of Coats' disease in adulthood. Clin Ophthalmol 2011;5:1729-32.  Back to cited text no. 14
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    Figures

  [Figure 1], [Figure 2], [Figure 3]
 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]


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