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LETTER TO THE EDITOR
Year : 2017  |  Volume : 65  |  Issue : 5  |  Page : 424

Head injury, varicella vasculopathy: Differential diagnosis for pediatric retinal arterial occlusion


Department of Neuro-ophthalmology, Clinic and Glaucoma Service, AG Eye Hospital, Trichy, Tamil Nadu, India

Date of Web Publication2-Jun-2017

Correspondence Address:
Natarajapillai Venugopal
No. 19, Mathuram Apartments (Behind YMCA), Officer's Colony, Puthur, Trichy - 620 017, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0301-4738.207452

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How to cite this article:
Venugopal N. Head injury, varicella vasculopathy: Differential diagnosis for pediatric retinal arterial occlusion. Indian J Ophthalmol 2017;65:424

How to cite this URL:
Venugopal N. Head injury, varicella vasculopathy: Differential diagnosis for pediatric retinal arterial occlusion. Indian J Ophthalmol [serial online] 2017 [cited 2024 Mar 29];65:424. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2017/65/5/424/207452

Dear Sir,

We read the article titled, “Idiopathic pediatric retinal artery occlusion” by Manayath et al.[1] We appreciate the authors effort. Authors have mentioned about absence of etiology in spite of extensive workup. We would like to highlight few points regarding asymptomatic oral trauma induced internal carotid artery spasm which may present as ischemic attack in anterior or middle cerebral artery territory.

Apart from posttraumatic cranial arterial spasm other conditions such as varicella vasculopathy (VV), chronic tonsillitis, cervical adenitis, and retropharyngeal abscess may cause childhood stroke.[2] Unilateral and bilateral occlusions of cervical internal carotid arteries may develop.

Stroke following intraoral trauma is rare. A high index of suspicion helps to identify this peculiar form of stroke in childhood. Penetrating or blunt trauma to pharynx may cause internal carotid artery occlusion. In mild injury, it may cause arterial spasm. Clinical manifestations may involve either anterior or middle cerebral artery region with overlapping or partial features depending on degree of occlusion and the competence of circle of Willis.[3]

Varicella vasculopathy is a differential diagnosis in pediatric stroke.[4] Initial infection with varicella-zoster virus results in chickenpox typically seen in patients 1–9 years of age. Central nervous system complications include self-limiting cerebellar ataxia, meningitis, meningoencephalitis, and vasculopathy. Stroke may occur months after chicken pox secondary to VV and is not always easy to diagnose. Stroke, transient ischemic attacks, mental status changes, fever, and headache are clinical features of VV. In VV, ischemic optic neuropathy can occur with normal cerebral angiogram and magnetic resonance imaging. Since VV can occur without rashes, all vasculopathies of unknown etiology should be evaluated for VV. Rapid diagnosis of VV is important since the mortality rate without treatment is 25%. Treatment with intravenous acyclovir, even after neurological disease has been present for months may be curative.

VV presents as acute hemiparesis, aphasia, hemianesthesia, focal neurological or retinal deficits [5] associated with mononuclear pleocytosis, and virus-specific antibodies in cerebrospinal fluid. Varicella-associated arterial ischemic stroke accounts for one-third of childhood ischemic stroke.

To conclude, proper history taking and meticulous clinical examination (multidisciplinary approach) supplemented by appropriate investigations are essential in pediatric retinal artery occlusion (branch and central).

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Manayath GJ, Shah PK, Narendran V, Morris RJ. Idiopathic pediatric retinal artery occlusion. Indian J Ophthalmol 2010;58:151-2.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Kaul S. Cerebrovascular disease in children. Indian Pediatr 2000;37:159-71.  Back to cited text no. 2
    
3.
Singhi P, Khandelwal NK, Mahajan V, Shahab S, Gupta V. Stroke following a bicycle injury. Indian J Pediatr 2007;74:856-8.  Back to cited text no. 3
    
4.
Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA. Varicella zoster virus infection: Clinical features, molecular pathogenesis of disease, and latency. Neurol Clin 2008;26:675-97, viii.  Back to cited text no. 4
    
5.
Selvakumar CJ, Justin C, Gnanaeswaran R, Chandrasekaran M. Post - varicella vasculopathy. J Assoc Physicians India 2010;58:572-3.  Back to cited text no. 5
    




 

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