BRIEF COMMUNICATION |
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Year : 2017 | Volume
: 65
| Issue : 8 | Page : 764-767 |
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Molecular pathologic interpretation of new retinoblastoma rosettes
Dipankar Das1, Panna Deka2, Kasturi Bhattacharjee2, Manab Jyoti Barman2, Harsha Bhattacharjee2, Divakant Misra2, Rushil Kumar Saxena2, Anusuya Bhattacharyya2, Apurba Deka2
1 Department of Ocular Pathology, Uvea and Neuro-Ophthalmology Services, Sri Sankaradeva Nethralaya, Guwahati, Assam, India 2 Sri Sankaradeva Nethralaya, Guwahati, Assam, India
Correspondence Address:
Dipankar Das Department of Ocular Pathology, Uveitis and Neuro-Ophthalmology Services, Sri Sankaradeva Nethralaya, Beltola, Guwahati - 781 028, Assam India
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/ijo.IJO_316_16
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Newly described retinoblastoma (RB) rosettes have various kinds of pathological significance. Some of their characteristics have been revealed in this immunohistochemistry study. Five paraffin-embedded eyeballs with RB and new rosettes were studied for neuron-specific enolase (NSE), p53, p16, BAX, c-Myc, glial fibrillary acidic protein, synaptophysin, and chromogranin. They were compared and interpreted using control specimens. NSE, P53, and P16 were significantly expressed in the cells of the new rosettes. The presence of new RB rosettes that mostly have histopathological high-risk factors and p53 positivity may be a strong marker of poor prognosis of RB.
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