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REVIEW ARTICLE FOR RESIDENTS
Year : 2018  |  Volume : 66  |  Issue : 2  |  Page : 190-194

Anatomy of cornea and ocular surface

Mittanamalli S Sridhar
Department of Ophthalmology, Krishna Institute of Medical Sciences, Hyderabad, Telangana, India

Date of Submission26-Jul-2017
Date of Acceptance20-Sep-2017
Date of Web Publication30-Jan-2018

Correspondence Address:
Dr. Mittanamalli S Sridhar
Department of Ophthalmology, Krishna Institute of Medical Sciences, Hyderabad, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_646_17

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  Abstract 


Important functions of cornea in the eye include protecting the structures inside the eye, contributing to the refractive power of the eye, and focusing light rays on the retina with minimum scatter and optical degradation. Considerable advances have taken place in understanding the organization of collagen in the corneal stroma and its clinical significance. In this review, the structure and function of various components of cornea and ocular surface are presented.

Keywords: Collagen, cornea, Descemet's membrane, endothelium, epithelium, stroma


How to cite this article:
Sridhar MS. Anatomy of cornea and ocular surface. Indian J Ophthalmol 2018;66:190-4

How to cite this URL:
Sridhar MS. Anatomy of cornea and ocular surface. Indian J Ophthalmol [serial online] 2018 [cited 2023 May 29];66:190-4. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2018/66/2/190/224089



Cornea and sclera constitute the outer covering or coat of the eyeball. The main purpose of this coat is to protect structures inside the eye. The cornea is a transparent avascular tissue that acts as a structural barrier and protects the eye against infections.[1] Along with the tear film, it provides proper anterior refractive surface for the eye. Cornea contributes to two-third of the refractive power of the eye.

The cornea is horizontally oval, measuring 11–12 mm horizontally and 9–11 mm vertically. The corneal horizontal diameter (white to white) using ORBSCAN II system has revealed average corneal diameter as 11.71 ± 0.42 mm. The average corneal diameter was 11.77 ± 0.37 in males compared to 11.64 ± 0.47 in females. The corneal diameter ranged from 11.04–12.50 in males and 10.7–12.58 in females.[2] The limbus is widest in superior and inferior cornea. Cornea is convex and aspheric. The anterior curvature is 7.8 mm and posterior curvature is about 6.5 mm. Cornea contributes to about 40–44 D of refractive power and accounts for approximately 70% of total refraction. The refractive index of cornea is 1.376. There is a gradual increase in thickness from central cornea to the periphery [3] [Figure 1]. Alteration in tissue thickness is due to increase in the amount of collagen in the peripheral stroma. With different methods of evaluation, the central corneal thickness in normal eyes is found to range from 551 to 565 μ and the peripheral corneal thickness from 612 to 640 μ.[4] The corneal thickness is found to decrease with age. Anterior corneal stromal rigidity appears to be particularly important in maintaining the corneal curvature. Anterior curvature resists changes to stromal hydration much more than posterior stroma.[1]
Figure 1: Picture of cornea showing central and peripheral cornea

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The cornea is made up of cellular and acellular components. The cellular components include the epithelial cells, keratocytes, and endothelial cells. The acellular component includes collagen and glycosaminoglycans. The epithelial cells are derived from epidermal ectoderm. The keratocyte and endothelial cells are derived from neural crest. The corneal layers include epithelium, Bowman's layer, stroma, Descemet's membrane, and endothelium [Figure 2]. Recently, a layer of cornea which is well defined, acellular in pre-Descemet's cornea is getting attention with the development of lamellar surgeries.[5] [Table 1] summarizes all layers of cornea with their functions.
Figure 2: Histopathology of cornea showing corneal epithelium, stroma, and Descemet's membrane

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Table 1: Corneal layers with their functions

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The corneal epithelium is composed fairly uniformly of 5–7 layers of cells [Figure 3]. It is about 50 μ in thickness. The epithelium is uniform to provide a smooth regular surface and is made up of nonkeratinized stratified squamous epithelium. The epithelium is derived from surface ectoderm between 5 and 6 weeks of gestation. The epithelium and the overlying tear film have symbiotic relationship. The mucin layer of the tear film which is in the direct contact with corneal epithelium is produced by the conjunctival goblet cells. It interacts closely with the corneal epithelial cells' glycocalyx to allow hydrophilic spreading of the tear film with each eyelid blink.
Figure 3: Histopathology of corneal epithelium and Bowman's membrane

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Cornea epithelial cells have a lifespan of 7 to 10 days undergoing involution, apoptosis, and desquamation. The presence of high concentrations of intracytoplasmic enzyme crystalline, like in lens epithelial cells, may play an important role in maintaining optical transparency. The epithelium is 5–6 layers structure with three types of cells: superficial cells, wing cells, and the basal cells. The superficial cells are 2–3 layers made up of flat polygonal cells. They have a diameter of 40–60 μ with a thickness of about 2–6 μ. The microvilli on the surface increase the surface area. The epithelial layer is made up of large dark cells and small light cells. Desmosomes form the tight junction in between the superficial cells. Thawing cells are 2–3 layered and are named as they have wing-like shape. They express 64-k dalton keratins. Basal cells are single layer of the epithelium which is cuboidal or columnar. They have abundant organelles and they are active mitotically.

The surface cells maintain tight junction complexes between the neighbors which prohibit tears from entering the intercellular spaces. The deepest cell layer of the epithelium is the basal layer, which compromises the single cell layer of epithelium approximately 20 μ tall. Besides the stem cells and transient amplifying cells, basal cells are the only corneal epithelial cells capable of mitosis. They are the source of wing and superficial cells.

Desmosomes are present along the lateral membranes of all epithelial cells, to keep the epithelial cells adherent to each other. The basal cells are attached to the underlying basement membrane by a hemidesmosomal system. The strong attachment prevents the epithelium getting separated from the underlying layers. Abnormality of this attachment results in corneal erosions and nonhealing epithelial defects.

Tight junctions are present only in the lateral wall of apical cells of epithelium, providing a permeability barrier between the cells at the most superficial level.[3] Adherens junctions are present along the lateral membrane of only the apical cells of the epithelium. They maintain cellular adherence in the region of tight junctions. Gap junctions are permeable channels on the lateral aspects of all epithelial cells, allowing the diffusion of small molecules.

The basement membrane of epithelial cells is 40–60 nm in thickness and is made up of Type IV collagen and laminin secreted by basal cells. The basement membrane is made up of lamina lucida and lamina densa. From the basal epithelial cells, anchoring fibrils pass through the basement membrane and end as anchoring plaques. The anchoring fibrils are made up of Type VII collagen and anchoring plaque is made up of Type I collagen [Figure 4]. If basement membrane is damaged, fibronectin levels increases and the process of healing can take up to 6 weeks.
Figure 4: Diagram depicting the junctional complexes of the corneal epithelium

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There are differences between epithelium of central and peripheral cornea. In the central cornea, the epithelium has 5–7 layers. The basal cells are columnar. There are no melanocytes or Langerhans cells. There is a smooth basal cell layer with keratan sulfate, and there are no lymphatics. In the peripheral cornea, the epithelium is 7–10 layered. The basal cells are cuboidal. There are melanocytes and Langerhans cells. There are undulating extensions of basal layer. There is no keratan sulfate and there are no lymphatics.

Thoft and Friend proposed the XYZ hypothesis of central epithelial maintenance.[6] X component denotes the basal cell proliferation. The Y component migration of cells from peripheral to central cornea and Z component denotes the loss of cells from the surface. The cells in the limbus are in two compartments. The stem cells and transient amplifying cells are in the proliferative compartment. The postmitotic cells and terminally differentiated cells are in nonproliferative compartment. The palisades of Vogt are undulations in basement membrane which provide increased vascularity, increased surface area for attachment, and also for provide protection to stem cells.

Bowman's membrane is condensation of collagen and proteoglycans. It is a 12 μ structure and is made up of Type I and V collagen as well as proteoglycans. It has no regenerative ability. Bowman's membrane lies just anterior to stroma and is not a true membrane. It is acellular condensate of the most anterior portion of the stroma. This smooth layer helps the cornea maintains its shape. When injured, this layer does not regenerate and may result in a scar.

The corneal stroma forms the bulk of the structural framework of the cornea and comprises approximately 80%–85% of its thickness. Embryologically, it is the result of second wave of neural crest migration that occurs in the 7th week of gestation, after establishment of the primitive endothelium. The stroma is characteristically transparent which is the result of precise organization of stromal fibers and extracellular matrix (ECM). The collagen within corneal fibrils is predominantly Type I. Type VI collagen and Type XII collagen are also found in stroma.[7]

The collagen fibers are arranged in parallel bundles called fibrils. These fibrils are packed in layers or lamellae. The stroma of the human eye contains 200–250 distinct lamellae, each layer arranged at right angles relative to fibers in adjacent lamella. The collagen in the stroma is laid down within lamellae. These structures are of the variable thickness, in humans up to 0.2 mm broad and 2 μm thick. At the center of the human cornea, there is approximately 200 lamellar thickness. The packing density is higher in the anterior lamellae than in the posterior stroma. These anterior lamellae are highly interwoven and most appear to insert into the Bowman's layer.[8] The mid-stromal lamellae are also highly interlaced. The posterior lamellae in the central cornea are more hydrated. The posterior stromal can swell easily whereas the more interwoven cannot.

Cornea lamellae in the deepest stroma have preferred directions which appear to close to inferior superior and nasal-temporal directions. X-rays scattering also has suggested a network of collagen lamella that enters the cornea close to the inferior, superior, nasal, and temporal which probably originate in the adjacent sclera. Collagen fibrils in the prepupillary appear to be more closely packed than in the peripheral cornea.[9] High packing density of stress-bearing collagen fibrils in the prepupillary cornea seems to be necessary for maintaining corneal strength and hence curvature in a region of reduced corneal thickness.

Collagen fibrils within the cornea are narrower than in many other connecting tissues, and there is an important factor for transparency, which is a function of diameter. There are about 300–400 triple-helical molecules within the cross section of the fibril. Ultrastructure within the organization of the lamellar appears to vary based on the depth within the stroma. Deeper layers are more strictly organized than superficial layers. This accounts for care of surgical dissection in a particular plane as one approaches the posterior depths of the corneal stroma.[1] During air injection into stroma, it is a common observation that part of the posterior stroma often adheres to the Descemet's membrane and there is a natural cleavage plane in the stroma almost 10 μ alone Descemet's membrane.[5]

A high refractive index and symmetric curvature are essential for optimal refractive power and minimum astigmatism of the cornea.[10] The architecture of the most anterior part (100–120 μ) of the stroma prevents changes in the morphology of the stromal region even after extreme swelling. The smooth curvature at the anterior side is not affected in conditions with increased corneal hydration. As the diameter of the cornea hardly changes, swelling is compensated by large undulations in Descemet's membrane at the posterior side. The corneal swelling behavior shows a gradual decrease in swelling from posterior to anterior side; this seems to be related to the organization of collagen lamellae and to the presence of different types of proteoglycan. In the posterior part keratan sulfate, a more hydrophilic proteoglycan is prevalent, whereas in the anterior part dermatan sulfate, a much less hydrophilic proteoglycan is prevalent. There is also an elastic fiber network within the stroma. These elastic fibers present throughout the stromal depth, are concentrated below the posterior-most keratocyte layer.

Cornea stroma is made up of keratocytes and ECM. The ECM is composed of collagens (Type I, III, V, VI) and glycosaminoglycans. The glycosaminoglycans constitute keratan sulfate, chondroitin sulfate, and dermatan sulfate. The corneal stroma has keratocytes and about 300 collagen lamellae which are regularly arranged. The glycosaminoglycans are predominantly keratan sulfate. Less contribution is by dermatan sulfate and chondroitin sulfate. Hyaluronan is seen in infancy.

Keratocytes are the major cell type of stroma. They are involved in maintaining the ECM environment. They are able to synthesize collagen molecules and glycosaminoglycans, while also creating matrix metalloproteinases (MMPs), all important in maintaining stromal homeostasis. Most of the keratocytes reside in the anterior stroma.

The Descemet's membrane is a 7 μ structure. It is made up of Type IV collagen and laminin. Descemet's membrane begins in utero at the 8-week stage. Endothelial cells continuously secrete Descemet's membrane. The anterior 3 μ secreted before birth has a distinctive banded appearance. Descemet's membrane produced after birth is unbanded and has an amorphous ultrastructural texture. Descemet's membrane can be up to 10 μ in thickness with age. The Descemet's membrane is elastic and curls on getting severed.

The endothelium is a single layer, 5 μ thick structure [Figure 5]. The cells are hexagonal and are metabolically active. There is an endothelial pump which regulates water content. Endothelium is a monolayer which appears as a honeycomb-like mosaic when viewed from the posterior side. In early embryogenesis, the posterior surface is lined with a neural crest-derived monolayer of orderly arranged cuboidal cells. The individual cells continue to flatten over time and stabilize at approximately 4 μ in thickness is adulthood. Adjacent cells share extensive lateral interdigitations and possess gap and tight junctions along the lateral borders. The lateral membrane contains the high density of Na + K + ATPase pump sites. The two most important ion transport systems are the membrane-bound Na + K + ATPase and the intracellular carbonic anhydrase pathway. Activity in both these pathways produces the net flux of ions from the stroma to the aqueous humor. The basal surface of the endothelium contains numerous hemidesmosomes that promote adhesion to Descemet's membrane.
Figure 5: Endothelial cell layer on the specular microscopy

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Immediately anterior to the flattened layer of endothelial cell is a discontinuous homogeneous acellular layer Descemet's membrane. At birth, the endothelial layer is approximately 10 μ thick. Descemet's membrane becomes continuous and uniform, fusing peripheral with the trabecular beams. The fusion site, known as Schwalbe line, is a gonioscopic landmark that defines the end of Descemet's membrane and the start of trabecular meshwork.

Endothelial cell density continues to change throughout life, from second to eight decades of life. The cell density declines from 3000 to 4000 cells/mm2 to around 2600 cells/mm2 of hexagonal cells decline from approximately from 75% to 60%. Endothelial cell density at birth is 3500 cells/mm2. Human central endothelial cell density decreases at an average of approximately 0.6% per year in normal corneas throughout adult life, into gradual increase in polymegathism and pleomorphism.[11] Endothelial cells do not regenerate in adults.[12]

A deep corneal layer has been getting attention recently. It is a well-defined, acellular, strong layer in the pre-Descemet's cornea.[5] This layer is found to be 5–8 lamellae of collagen fibers ranging from 6 to 15 μ in thickness. There are no keratocytes in this layer, and it is impervious to air. In donor eyes from eye banks, the bubble can be inflated to pressure about 700 mmHg before it ruptures. It is also found in children.

The cornea is one of the most heavily innervated and most sensitive tissues in the body. The sensation is derived from the nasociliary branch of the first division of (ophthalmic) of the trigeminal nerve. Thick and straight stromal nerve trunks extend laterally and anteriorly to give rise to plexiform arrangements of progressively thin nerve fibers at several levels within the stroma.[13] The nerve fibers perforate Bowman's layer and eventually form a dense nerve plexus just beneath the basal epithelial cell layer characterized by tortuous, thin beaded nerve fibers interconnected by numerous nerve elements. The cornea also contains autonomic sympathetic nerve fibers.

Normal human cornea is avascular. The aqueous humor is the main source of nutrients to the cornea. Blood supply is by tiny vessels at the outer edge of the cornea as well as components supplied by end branches of the facial and ophthalmic arteries through the aqueous humor and the tear film.


  Tear Film Top


The minute surface irregularities of the corneal surface epithelium are masked by a smooth and regular overlying tear film. The tear film is the first layer of the cornea with which light comes into contact. In produces lubrication and hydration to the ocular surface. It is also a source of oxygen, immunoglobulins, lysozymes, lactoferrin, and α- and β-defensins. The tear film is traditionally told to be composed of three distinct layers. The most superficial layer is composed of oily secretions of  Meibomian gland More Detailss. Because oil is less dense than water, the secretions float to the top of the tear film to form a smooth refractive surface. This oily layer also provides an important barrier against the evaporation of the tear film. The aqueous middle layer of the tear film lies immediately beneath the oily layer. It is produced from the secretion of the lacrimal gland which is located in the superior lateral orbit. The aqueous is secreted onto the ocular surface from ducts in the superior fornix. There are also numerous scattered accessory lacrimal glands embedded within the conjunctiva stroma which contribute to this aqueous layer. The innermost mucin layer is produced primarily by the conjunctival goblet cells although the epithelial cells of the cornea and the conjunctiva also contribute. Current understanding is that all the three layers are in the form of a gel on the ocular surface. Conjunctival goblet cells seem to be important in performing the functions of debris removal and immune surveillance.[14]


  Ocular Surface Top


Thoft and Friend first suggested that cornea, conjunctiva, lacrimal glands, and lids work as an integrated unit called ocular surface.[15] The anatomical ocular surface is composed of the mucosa that lines the globe and palpebral surfaces, the corneoscleral limbus, the corneal epithelium, and the tear film.[16]

Sclera, in contrast to cornea, has collagen fibrils which are more haphazard and random. The bulk of stroma is mostly acellular, except for outer episcleral layer.

Conjunctiva extends from the limbus to the fornices, forming a fold at the fornices of the eyelid and then extends back around onto the posterior surface of the eyelids. Plica semilunaris is a crescent-shaped fold of conjunctiva medially with thickened stroma. The caruncle is located medial to the plica and marks the most medial aspect of the interpalpebral fissure. The bulbar conjunctiva is fairly loosely adherent to the underlying anterior Tenon's capsule. On histology, the conjunctiva is composed of a surface layer of nonkeratinizing stratified squamous epithelium overlying vascular stroma composed of loose connective tissue. A unique feature of conjunctiva is the presence of goblet cells in stratified squamous epithelium. These goblet cells are specialized apocrine cells which provide the mucin layer to the tear film.[15] The specific mucin type secreted by these cells has been identified as MUC5AC.

Eyelids provide mechanical protection for the ocular surface. Constant blinking of the lids renews the tear film over the surface of the cornea and mechanically removes away superficially adherent foreign bodies and bacteria. Viewed in cross section, it is composed of five layers. The first layer is the cutaneous epithelium consisting of stratified squamous epithelium. The epithelium rests on very thin dermis. The orbicularis oculi muscle is a striated muscle that surrounds the orbital margins. Deep to the orbicularis lies the orbital septum, a membrane sheet which separates the preseptal space from the posterior orbit. Underneath the septum lie the retractors of the eyelids. The tarsus has a cartilaginous consistency. It is composed of dense connective tissue which molds tightly to the curvature of the eye to keep the eyelid firmly on the surface. Within the tarsus are numerous specialized sebaceous glands called the meibomian glands opening at the lid margin. Their secretions are the main source of superficial lipid layer of the tear film. Each eyelash follicle is also associated with sebaceous glands called the glands of Moll. In addition, there are associated apocrine glands called the glands of Zeis.

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Conflicts of interest

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  References Top

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Fares U, Otri AM, Al-Aqaba MA, Dua HS. Correlation of central and peripheral corneal thickness in healthy corneas. Cont Lens Anterior Eye 2012;35:39-45.  Back to cited text no. 3
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    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
 
 
    Tables

  [Table 1]


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25 Updates on Biodegradable Formulations for Ocular Drug Delivery
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26 Dendrimers in Corneal Drug Delivery: Recent Developments and Translational Opportunities
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27 Recent Approaches to the Modification of Collagen Biomatrix as a Corneal Biomatrix and Its Cellular Interaction
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28 Prolonged Inflammation and Infectious Changes in the Corneal Epithelium Are Associated with Persistent Epithelial Defect (PED)
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29 Medical student competence in ophthalmology assessed using the Objective Standardized Clinical Examination
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30 Single-cell RNA sequencing in cornea research: Insights into limbal stem cells and their niche regulation
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31 Efficacy Of Using Cationorm and Systane Eye Drops on Post-Lasik Dry Eye
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32 A Review of Corneal Blindness: Causes and Management
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33 Corneal Biomechanical Parameters after 60-Year-Old
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34 Correlation between corneal tomography and postphacoemulsification positive dysphotopsia
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35 Bioprinted Membranes for Corneal Tissue Engineering: A Review
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36 Therapeutic Potential of Honey and Propolis on Ocular Disease
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37 Collagen as a Biomaterial for Skin and Corneal Wound Healing
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38 Antibacterial and Oxidative Stress-Protective Effects of Five Monoterpenes from Softwood
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39 Pituitary Adenylate Cyclase-Activating Polypeptide Protects Corneal Epithelial Cells against UV-B-Induced Apoptosis via ROS/JNK Pathway Inhibition
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40 Therapeutic Strategies for Restoring Perturbed Corneal Epithelial Homeostasis in Limbal Stem Cell Deficiency: Current Trends and Future Directions
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41 Raman Spectroscopic Study of Amyloid Deposits in Gelatinous Drop-like Corneal Dystrophy
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42 Corneal Behavior during Tonometer Measurement during the Water Drinking Test in Eyes with XEN GelStent in Comparison to Non-Implanted Eyes
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43 Alginate-Based Composites for Corneal Regeneration: The Optimization of a Biomaterial to Overcome Its Limits
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44 Ocular Surface Infection Mediated Molecular Stress Responses: A Review
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45 Human SMILE-Derived Stromal Lenticule Scaffold for Regenerative Therapy: Review and Perspectives
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46 The Underlying Relationship between Keratoconus and Down Syndrome
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47 Effect of Polydeoxyribonucleotide (PDRN) Treatment on Corneal Wound Healing in Zebrafish (Danio rerio)
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48 Autophagy in Extracellular Matrix and Wound Healing Modulation in the Cornea
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49 Features of morphological and ultrastructural organization of the cornea (literature review)
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50 Monoclonal Antibodies: A Therapeutic Option for the Treatment of Ophthalmic Diseases of the Eye Posterior Segment
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51 Cornea: anatomical and functional features, new methods of in vivo diagnostics of abnormalities
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52 Corneal Topographic versus Manifest Refractive Astigmatism in Patients with Keratoconus: A Retrospective Cross-Sectional Study
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53 Polyunsaturated Fatty Acid-Derived Lipid Mediators That Regulate Epithelial Homeostasis
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54 Bio-fabrication of stem-cell-incorporated corneal epithelial and stromal equivalents from silk fibroin and gelatin-based biomaterial for canine corneal regeneration
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55 A global bibliometric and visualized analysis in the status and trends of corneal tissue engineering research from 1991 to 2021
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56 Scaffold-Free Strategy Using a PEG–Dextran Aqueous Two-Phase-System for Corneal Tissue Repair
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57 Hyaluronan Modulates the Biomechanical Properties of the Cornea
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58 Novel vision restoration techniques: 3D bioprinting, gene and stem cell therapy, optogenetics, and the bionic eye
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59 Capsanthin from Capsicum annum fruits exerts anti-glaucoma, antioxidant, anti-inflammatory activity, and corneal pro-inflammatory cytokine gene expression in a benzalkonium chloride-induced rat dry eye model
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60 Finite Element Analysis of Cornea and Lid Wiper during Blink, with and without Contact Lens
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61 Unintentional Descemet Cleft Introduces Novel Mechanism of Maintenance of Corneal Clarity
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62 Mobile-CellNet: Automatic Segmentation of Corneal Endothelium Using an Efficient Hybrid Deep Learning Model
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63 Molecular characterization of fungal endophthalmitis and keratitis caused by yeasts
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64 A rapid review of the red eye
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65 Functional optimization of electric cell-substrate impedance sensing (ECIS) using human corneal epithelial cells
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66 Inverse Hartmann test for radius of curvature measurement in a corneal topography calibration sphere
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67 Bio-polymeric hydrogels for regeneration of corneal epithelial tissue*
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68 Teprotumumab for chronic thyroid eye disease
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69 Eye Make-up Products and Dry Eye Disease: A Mini Review
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70 Genetic screening of TGFBI in Iranian patients with TGFBI-associated corneal dystrophies and a meta-analysis of global variation frequencies
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71 Mucosal immunology of the ocular surface
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72 Electrospun-Reinforced Suturable Biodegradable Artificial Cornea
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73 Multiple roles of Pax6 in postnatal cornea development
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74 Clinical and biochemical footprints of inherited metabolic disorders. VII. Ocular phenotypes
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75 Necroptosis Contributes to Airborne Particulate Matter-Induced Ocular Surface Injury
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76 A review of described cases of mycotic keratitis and sclerokeratitis related to entomopathogenic fungi from 1984 to 2021
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77 Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets
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78 Non-canonical Wnt signaling in the eye
Ruchi Shah, Cynthia Amador, Steven T. Chun, Sean Ghiam, Mehrnoosh Saghizadeh, Andrei A. Kramerov, Alexander V. Ljubimov
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79 LNP-mediated delivery of CRISPR RNP for wide-spread in vivo genome editing in mouse cornea
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80 Ocular delivery of cyclosporine A using dissolvable microneedle contact lens
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81 Lipid-based nanocarriers for ocular drug delivery: An updated review
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82 Evaluation of corneal, ocular surface, and meibomian gland changes in obstructive sleep apnea syndrome
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83 Evaluating the clinical translational relevance of animal models for limbal stem cell deficiency: A systematic review
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84 Functionalized hydrogels in ophthalmic applications: ocular inflammation, corneal injuries, vitreous substitutes and intravitreal injection
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85 A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles
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86 Epithelial cells removed in advanced surface ablation (ASA) surgery can be used as a source of corneal samples to perform in vitro studies
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87 Analysis of different conditioned media secreted by limbal progenitor cells in the modulation of corneal healing
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88 Direct oral mucosal epithelial transplantation supplies stem cells and promotes corneal wound healing to treat refractory persistent corneal epithelial defects
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89 Biochemistry of human tear film: A review
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90 Resveratrol increases tear production and ocular pain after corneal abrasion in male, but not female, rats using a photorefractive keratectomy model
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91 Trio-based exome sequencing broaden the genetic spectrum in keratoconus
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92 Cytokine profile of human limbal myofibroblasts: Key players in corneal antiviral response
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93 From ocular immune privilege to primary autoimmune diseases of the eye
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94 p63 in corneal and epidermal differentiation
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95 Print me a cornea - Are we there yet?
Midhun Ben Thomas, Shivaram Selvam, Parinita Agrawal, Prayag Bellur, Neha Waghmare, Suvro K. Chowdhury, Kamalnath Selvakumar, Aastha Singh, Anil Tiwari, Abha Gour, Virender S. Sangwan, Tuhin Bhowmick, Arun Chandru
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96 Segmentation methods and morphometry of confocal microscopy imaged corneal epithelial cells
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97 PIPE-Net: A pyramidal-input-parallel-encoding network for the segmentation of corneal layer interfaces in OCT images
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98 Role of autophagy in the eye: from physiology to disease
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99 Tissue Engineered Mini-Cornea Model for Eye Irritation Test
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100 Anatomie et physiologie de l’œil
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101 Investigation of the effect of solution pH value on rabbit corneal stroma biomechanics
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102 Low-intensity low-frequency ultrasound mediates riboflavin delivery during corneal crosslinking
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103 Longitudinal assessment of the effect of alkali burns on corneal biomechanical properties using optical coherence elastography
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104 Scanning electron microscopy and morphometric analysis of superficial corneal epithelial cells in dromedary camel ( Camelus dromedarius )
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105 Gold-based blood serum treatment promotes wound closure of corneal epithelial cell defects in primary in vitro experiments
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106 Non-infectious and non-hereditary diseases of the corneal epithelium
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107 The role of fungi in fungal keratitis
Bethany Mills, Naveen Radhakrishnan, Siva Ganesa Karthikeyan Rajapandian, Gunasekaran Rameshkumar, Prajna Lalitha, N. Venkatesh Prajna
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108 Corneal angiogenic privilege and its failure
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109 Super-resolution imaging of flat-mounted whole mouse cornea
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110 The role of peroxisome proliferator-activated receptors in healthy and diseased eyes
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111 Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies
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112 Electrospun GelMA fibers and p(HEMA) matrix composite for corneal tissue engineering
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113 A single cell atlas of human cornea that defines its development, limbal progenitor cells and their interactions with the immune cells
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114 Descemetorhexis traumatique après exérèse chirurgicale de chalazion : à propos d’un cas
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115 Corneal lymphangiogenesis as a potential target in dry eye disease - a systematic review
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116 Stem cell-based therapeutic strategies for corneal epithelium regeneration
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