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OPHTHALMIC IMAGE |
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Year : 2018 | Volume
: 66
| Issue : 9 | Page : 1330-1331 |
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Anterior lenticonus associated with Alport syndrome
Jitender Jinagal1, Gaurav Gupta1, Faisal Thattaruthody1, Ritambhra Nada2, Jagat Ram1
1 Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India 2 Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Date of Web Publication | 20-Aug-2018 |
Correspondence Address: Dr. Jagat Ram Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012 India
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/ijo.IJO_400_18
How to cite this article: Jinagal J, Gupta G, Thattaruthody F, Nada R, Ram J. Anterior lenticonus associated with Alport syndrome. Indian J Ophthalmol 2018;66:1330-1 |
A 22-year-old male presented with urinary complaints. On ocular examination, his best corrected visual acuity was 20/80 OU. Slit lamp examination revealed conical protrusion of anterior surface of crystalline lens suggestive of anterior lenticonus in left eye [Figure 1]a. Retinoscopy revealed ‒2.0 DS/‒1.50 DC @ 160o in left eye and dull glow due to cataract in right eye. Scheimpflug imaging confirmed the examination findings of anterior lenticonus [Figure 1]b. Fundus was normal. Electron microscopy findings of renal biopsy were suggestive of Alport syndrome [Figure 2]a and [Figure 2]b. | Figure 1: (a) Anterior segment photograph showing conical protrusion of anterior surface of crystalline lens suggestive of anterior lenticonus; (b) Scheimpflug image supporting the clinical findings of anterior lenticonus
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| Figure 2: Electron microscopy photographs showing; (a) Glomerular capillaries having thin (arrows) and thick areas (stars) with loss of tri-lamellar structure of basement membrane. There are no immune complex type of deposits( Uranyl acetate, x1000 direct magnification), (b) glomerular capillaries having variable thickness and extensive splitting of basement membrane giving basket weave appearance (Uranyl acetate, x5000 direct magnification)
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Conclusion | | |
Anterior lenticonus is a rare condition, commonly associated with Alport syndrome, which is characterized by genetically defective synthesis of Type IV collagen.[1],[2]
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
References | | |
1. | Savige J, Sheth S, Leys A, Nicholson A, Mack HG, Colville D. Ocular features in Alport syndrome: Pathogenesis and clinical significance. Clin J Am Soc Nephrol 2015;10:703-9. |
2. | Miner JH, Baigent C, Flinter F, Gross O, Judge P, Kashtan CE, et al. The 2014International Workshop on Alport Syndrome. Kidney Int 2014;86:679-84. |
[Figure 1], [Figure 2]
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