|LETTER TO THE EDITOR
|Year : 2019 | Volume
| Issue : 8 | Page : 1382-1383
Feasibility and outcome of simple limbal epithelial transplantation (SLET) in unilateral total limbal stem cell deficiency (LSCD) following chemical injury, in a semiurban location in Western India
Sushmita G Shah1, Shreya M Shah2, Juhee Agarwal2, Ankita Mulchandani2
1 Cornea and Anterior Segment Services, Drashti Nethralaya, Dahod, Gujarat; Eye Life; Netra Mandir, Mumbai, Maharashtra, India
2 Cornea and Anterior Segment Services, Drashti Nethralaya, Dahod, Gujarat, India
|Date of Web Publication||22-Jul-2019|
Dr. Sushmita G Shah
Eye Life, 204 Ram Krishna Chambers, Liking Road, Khar West, Mumbai – 52
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Shah SG, Shah SM, Agarwal J, Mulchandani A. Feasibility and outcome of simple limbal epithelial transplantation (SLET) in unilateral total limbal stem cell deficiency (LSCD) following chemical injury, in a semiurban location in Western India. Indian J Ophthalmol 2019;67:1382-3
|How to cite this URL:|
Shah SG, Shah SM, Agarwal J, Mulchandani A. Feasibility and outcome of simple limbal epithelial transplantation (SLET) in unilateral total limbal stem cell deficiency (LSCD) following chemical injury, in a semiurban location in Western India. Indian J Ophthalmol [serial online] 2019 [cited 2023 Mar 22];67:1382-3. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2019/67/8/1382/263118
Simple limbal epithelial transplantation (SLET) was first described by Sangwan et al. as an innovative technique for the management of unilateral total limbal stem cell deficiency (LSCD). Subsequently, its efficacy has been described by Vazirani et al. in a multicenter study conducted across advanced eye care centers in urban locations in India, United States, and Mexico.
We describe the outcome and feasibility of performing SLET by a trained corneal surgeon in a semi-urban setting in western India. Patients with unilateral total LSCD following chemical injury with healthy fellow eye were included. Surgical technique as described by Sangwan et al. was followed. Outcome measures were as follows: (i) Improvement in visual acuity, (ii) improvement in corneal clarity and LSCD, (iii) ease of performing SLET in a semi-urban setting.
Three patients, two males and one female with age range 13-16 years were included in the study. One patient had history of lime burn while two had exposure to unknown chemicals. At mean follow up of 4.33 months (range 2-6 months), two patients (66.6%) improved from preoperative visual acuity of <20/400 to 20/80 and 20/60, respectively. One patient remained at 20/400 which could be attributed to pre-existing amblyopia. Complete resolution of LSCD was noted in two patients (66.6%) while one patient had localized residual pannus of 1 clock hour.
Our results are comparable to that of the multicenter study. As mentioned by Basu et al., the advantages of SLET include minimal surgical paraphernalia, logistical support, and training. In our study, the procedures were easily performed by an experienced cornea specialist who had attended SLET workshops and had performed a few cases of SLET prior to this study. The other essential requirements include fresh frozen amniotic membrane and fibrin glue which can be made available even in semi-urban areas. SLET can thus be performed in hospitals located in such areas.
To conclude, this study establishes that SLET could be performed by a trained corneal surgeon even in semi-urban settings with useful outcomes.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Sangwan VS, Basu S, MacNeil S, Balasubramanian D. Simple limbal epithelial transplantation (SLET): A novel surgical technique for the treatment of unilateral limbal stem cell deficiency. Br J Ophthalmol 2012;96:931-4.
Vazirani J, Ali MH, Sharma N, Gupta N, Mittal V, Atallah M, et al
. Autologous simple limbal epithelial transplantation for unilateral limbal stem cell deficiency: Multicentre results. Br J Ophthalmol 2016;100:1416-20.
Basu S, Bahuguna C, Singh V. Simple limbal epithelial transplantation: Impactful innovation. Ind J Ophthalmol 2018;66:53-4.