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Year : 2019  |  Volume : 67  |  Issue : 9  |  Page : 1507

Primary orbital low-grade fibromyxoid sarcoma

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Web Publication22-Aug-2019

Correspondence Address:
Prof. Mahmood Dhahir Al-Mendalawi
P.O. Box 55302, Baghdad Post Office, Baghdad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_583_19

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How to cite this article:
Al-Mendalawi MD. Primary orbital low-grade fibromyxoid sarcoma. Indian J Ophthalmol 2019;67:1507

How to cite this URL:
Al-Mendalawi MD. Primary orbital low-grade fibromyxoid sarcoma. Indian J Ophthalmol [serial online] 2019 [cited 2023 Dec 8];67:1507. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2019/67/9/1507/265122


In April 2019 issue of the Indian Journal of Ophthalmology, Rao et al.[1] reported a case of primary orbital low-grade fibromyxoid sarcoma (LGFS), classified by the World Health Organization as a malignant fibroblastic/myofibroblastic neoplasm, in an Indian patient. The authors described the clinical picture, imaging findings, histopathologic and immunohistochemical studies, and the radiotherapy plan. I assume that the aggressive nature and rarity of that tumor to primarily affect an unusual site must trigger the authors to take into consideration weak immune status in the studied patient. Among states associated with weak immunity, infection with human immunodeficiency virus (HIV) has the leading priority. Due to low immunity, co-infection with oncogenic viruses, and life extension due to the antiretroviral therapy, individuals with HIV infection tend to have various forms of tumors in comparison with immunocompetent individuals.[2] Indeed, myofibroblastic tumor has been reported among HIV-infected patients.[3] In India, HIV infection is an important health problem. Though no recent data are yet present on the seroprevalence of HIV infection in India, the available data reported the overall HIV seroprevalence of 0.26% compared to a global average of 0.2%.[4] I assume that HIV infection should be critically considered in the studied patient with LGFS affecting an unusual site. Hence, it was envisaged to conduct the diagnostic algorithm of blood CD4 lymphocyte count and viral overload estimations for HIV infection. If that algorithm was to reveal HIV positivity, the case in question could be regarded a novel case report of HIV-associated primary orbital LGFS in the literature.

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There are no conflicts of interest.

  References Top

Rao R, Honavar SG, Mulay K, Reddy VA. Primary orbital low-grade fibromyxoid sarcoma – a case report. Indian J Ophthalmol 2019;67:568-70.  Back to cited text no. 1
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Valencia Ortega ME. Malignancies and infection due to the human immunodeficiency virus. Are these emerging diseases? Rev Clin Esp 2018;218:149-55.  Back to cited text no. 2
Cambrea SC, Resul G, Bulbuc I, Cambrea M, Vasilescu F. Pulmonary inflammatory myofibroblastic tumor in an AIDS patient. Rom J Morphol Embryol 2014;55:407-12.  Back to cited text no. 3
Paranjape RS, Challacombe SJ. HIV/AIDS in India: An overview of the Indian epidemic. Oral Dis 2016;22(Suppl 1):10-4.  Back to cited text no. 4


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