• Users Online: 201
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 2020  |  Volume : 68  |  Issue : 10  |  Page : 2067-2074

Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus

1 Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, Karnataka, India
2 Department of Paediatrics, Allergy and Immunology, Manipal Hospital, Bangalore, Karnataka, India
3 GROW Research Laboratory, Narayana Nethralaya Foundation, Bangalore, Karnataka, India

Date of Submission01-Jul-2019
Date of Acceptance24-Mar-2020
Date of Web Publication23-Sep-2020

Correspondence Address:
Dr. Sharon D'Souza
Department of Ocular Surface and Refractive, Narayana Nethralaya, 121/c, Chord Road, Rajajinagar, Bangalore, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1191_19

Rights and Permissions

Keratoconus (KC) is an ectatic disease of the cornea characterized by localized thinning and protrusion causing irregular astigmatism, which can lead to significant visual impairment. KC has often been associated with allergy and/or atopy, which are immune-mediated inflammatory reactions primarily driven by IgE. A higher proportion of KC patients were reported to have history or suffer from systemic and/or ocular allergy with elevated allergen-specific IgE and/or total serum IgE. Eye rubbing, one of the risk factors for worsening of the disease and developing related complications in KC, is associated with IgE driven conditions. The current review enumerates and contextualizes the evidence related to IgE in mediating KC pathogenesis, including aberrant extra-cellular matrix remodeling. This review also discusses clinical strategies directed at modulating IgE-mediated responses in the management of KC, and the emerging academic and plausible clinical relevance of assessing serum and tear IgE (allergen-specific and total) status in improving the understanding of disease pathobiology, treatment planning, and prognosis.

Keywords: Allergy, atopy, eye rubbing, IgE, keratoconus

How to cite this article:
Ahuja P, Dadachanji Z, Shetty R, Nagarajan SA, Khamar P, Sethu S, D'Souza S. Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus. Indian J Ophthalmol 2020;68:2067-74

How to cite this URL:
Ahuja P, Dadachanji Z, Shetty R, Nagarajan SA, Khamar P, Sethu S, D'Souza S. Relevance of IgE, allergy and eye rubbing in the pathogenesis and management of Keratoconus. Indian J Ophthalmol [serial online] 2020 [cited 2022 Nov 29];68:2067-74. Available from: https://www.ijo.in/text.asp?2020/68/10/2067/295661

Keratoconus (KC) is a corneal ectatic disorder characterized by thinning and forward protrusion of a localized portion of the cornea. In the initial stages the patient may present with varying degrees of irregular astigmatism correctable by glasses but advanced cases can result in a significant drop in vision due to the worsening ectasia and even corneal scarring in some cases.[1],[2],[3] KC is usually known to have an onset early in the second decade of life. It can be progressive in a subset of patients or spontaneously stabilize in others.[4] The early stages of KC can be managed by glasses and rigid contact lens for visual rehabilitation, and collagen crosslinking if there is a progression of the disease. Adjunct treatment modalities like intra corneal ring segments or topography-guided treatments have also been described with good effect. The advanced stage of KC may need a corneal transplant to restore vision. Hence, identifying KC in early stages and managing it by treating the known risk factors, may provide ample chance for the disease to stabilize without further deterioration. During the early stages of KC, prior to the use of surgical strategies listed above, it would be beneficial to prophylactically reduce potential risk factors and associated events. Ocular allergy and eye rubbing in particular have been shown as key contributors in the pathogenesis of KC.[5],[6] Hence, managing associated ocular allergy and eye rubbing in addition or ahead of other therapeutic strategies would be beneficial in improving the prognosis of KC. The current review collates, contextualizes, and examines an underlying modifiable factor, IgE – which is a key driver of allergic responses, with reference to the pathogenesis and management of KC.

  Allergy, Atopy, and Eye Rubbing in KC Top

Ocular and systemic allergy including atopy have emerged as one of the key modifiable risk factors associated with KC pathogenesis. The pathological role and relationship between ocular allergy and KC has been discussed in detail by Sharma et al. earlier.[5] Atopy is a condition associated with the inherent or genetic predisposition to develop allergy due to exaggerated immune response against common allergens. Atopy can have manifestations in skin (dermatitis), respiratory tract (rhinitis, asthma), and the ocular surface (conjunctivitis). Allergy and atopy have long been associated with KC and a summary of findings regarding the relationship between allergy and atopic conditions and KC prevalence from key reports have been enumerated in [Table 1]. Even though few studies have shown no significant association between KC and ocular allergy, a majority of studies showed a positive association between them.[7],[8],[9],[10],[11],[12],[13] The prevalence of allergy across the varying grades of KC ranges from 11.3 to 30% of KC patients.[8],[10],[11],[12] Studies have shown that KC is more prevalent in children with vernal keratoconjunctivitis (VKC), and VKC has also been found to have effect on progression of the KC. Even though the progression of KC was not affected by the severity of allergic eye disease in one study, there have been other reports where allergic eye disease was found to be associated with higher grade of KC at presentation.[13] Another strongly associated risk factor in KC pathogenesis is eye rubbing and this relationship has been extensively reviewed in many recent articles on the subject.[14],[15]
Table 1: The status of Atopy/Allergy in Keratoconus

Click here to view

KC patients with ocular allergy are also at a higher risk of developing other ocular complications like acute hydrops and corneal scarring, which could be related to the associated eye rubbing in these patients. These patients may require surgical intervention including intrastromal corneal ring segments or keratoplasty for visual rehabilitation.[16],[17] Ocular allergy and eye rubbing can also have a detrimental effect on the outcomes of surgical procedures on the eye due to the associated inflammation and mechanical trauma. Allergy and atopy have also been linked to complications related to KC management such as graft and intrastromal corneal ring segment outcomes.[18],[19] Collagen crosslinking is a procedure done to halt the progression of KC. Studies have shown an increased risk of progression of KC even after collagen crosslinking in patients with ocular and systemic allergy.[20],[21],[22] This could be related to the mechanical trauma due to eye rubbing and the inflammation and cytokines released. These patients could require repeat collagen crosslinking.[20],[22] In addition, the outcomes of keratoplasty for advanced KCwas evaluated in various studies.[23],[24] It was found that the there was no difference in the outcomes of keratoplasty including visual outcomes and graft survival or the risk of graft rejection among the KC patients with and without (VKC).[23],[24] However, certain complications like early loosening of sutures, epithelial breakdown, and steroid related complications showed an increased incidence in the KC patients with associated ocular allergy who underwent keratoplasty.[23]

  Serum Ige and KC Top

A key factor that is a common mediator to the major risk factors (allergy, atopy, and eye rubbing) associated with KC is Immunoglobulin E (IgE). It is well known that the signs and symptoms associated with allergy and atopy including ocular manifestations are primarily driven by IgE-mediated cellular responses.[25],[26],[27] Hence, a detailed review of literature was conducted to evaluate the status of IgE in KC patients with and without allergy or atopy across different studies [Table 2]. It is evident that a significant number of KC patients do have higher levels of serum IgE. It has also been shown that KCs patients who have allergy have significantly high serum IgE levels than those without clinical signs and symptoms of allergy.[7],[13] Elevated serum IgE is also associated with a subset of KC patients even without significant signs of ocular allergy.[7],[8] The association of serum total IgE and s pecific IgE levels in KC patients has been evaluated by Rahi A et al.[7],[13] along with association to other immunoglobulins. No significant association or trend was found in the serum levels of other immunoglobulins. Kemp et al. evaluated the association of total serum IgE and allergen specific IgE in patients with keratoconus and found a 52% incidence of elevated levels of total serum IgE in patients with keratoconus and 59% of raised serum specific IgE levels.[8] Increased serum IgE was also reported to be associated with the progression of the disease and graft rejection in KC patients.[28],[29] Based on reports listed in [Table 2], it is important to note that there could very well be a subset of KC patients with raised IgE, but without any history or ongoing allergy/atopy. However, the reason underlying this observation is yet to be ascertained and could be attributed to sub-clinical allergy or measurement variation. Irrespective of the etiology underlying the raised IgE in KC patients, it would be beneficial to reduce IgE levels and mitigate IgE mediated effects to improve KC prognosis.
Table 2: The status of IgE in Keratoconus

Click here to view

  Tear Ige and KC Top

Ocular surface IgE levels in KC patients would provide the much-needed relevant information pertaining to the actual role of allergy in causing KC. Measuring IgE level from the tear fluid would be an ideal strategy to determine the status of IgE on the ocular surface of patients. Altered tear fluid IgE levels have been reported in a variety of ocular surface conditions including ocular allergy, dry eye, and corneal dystrophies.[30],[31],[32],[33] However, the information regarding the status of tear IgE in KC patients is almost nil, expect for a couple of reports. A study by Rahi A et al. showed that there was higher levels of IgE in serum, but not in tear fluid of KC patients compared to controls.[7] However, a more recent finding stated in a conference proceedings reports a significant increase in both serum and tear IgE levels were observed in KC patients without allergy compared to controls.[34] More studies assessing tear IgE levels in KC are required to improve this knowledge base. There is mounting evidence regarding the usefulness of tear IgE assessment in ocular surface conditions, and tear IgE levels are reported to associate with the severity of ocular surface conditions and allergenic factors.[32],[35],[36],[37],[38] Further, correlation between tear and serum IgE levels [39],[40] and a significant positive relationship between allergen-specific tear IgE and skin prick test [41],[42] were also reported. Tear IgE measurements for diagnostic purpose needs further standardization that would requires large scale population studies to determine normative data and the type of tear collection method (Schirmer's strip or capillary tube). Until then tear IgE measurement will remain a supplemental tool in diagnosis and treatment planning. However, total and allergen-specific IgE levels in the tear fluid of KC patients would be of immense value in studying the mechanistic role of allergy or IgE in KC pathogenesis and prognosis.

  Ige Associated KC Pathogenesis Top

KC was previously considered as a non inflammatory condition. However, in the last decade, various studies have confirmed the inflammatory basis of KC pathogenesis.[43],[44],[45],[46],[47] The local (ocular surface) manifestation of a IgE-based systemic immunological imbalance common in allergy or atopy could possibly be related to the underlying inflammatory nature of KC leading to changes in the collagen and keratocytes in the ectatic region. IgE exerts its function including protection against parasites by the binding of the Fc portion of the antigen bound IgE to Fc-epsilon receptor (FcεR) present on the surface of variety of cells such as mast cells, basophils, eosinophils, epithelial cells, and neurons.[27],[48],[49] Mast cells, basophils, and eosinophils primarily in the tissues degranulate when stimulated by binding of IgE-bound to an allergen (IgE-IC; IgE immune complex) to FcεR on their surface.[26] [Figure 1] outlines the proposed IgE-mediated events that may underlie KC pathogenesis. Briefly, (i) IgE-FcεR degranulates granulocytes resulting in the release of itch factors and inflammatory mediators; (ii) the released inflammatory mediators such as the allergy associated cytokines and chemokines can orchestrate the trafficking of immune cells further propagating the inflammatory milieu on the ocular surface; (iii) itch factors along with additional inflammatory mediators results in eye rubbing, which delivers mechanical trauma to the corneal tissues and also stimulates inflammatory factors, and (iv) inflammatory milieu along with proteases compromises extra-cellular matrix remodeling processes resulting in ectasia.
Figure 1: Proposed role of IgE in keratoconus pathogenesis. Schematic hypothesizes that raised IgE will bind to its receptor (FcεR) on the ocular surface immune cells including mast cells. Binding of IgE to FcεR results in the degranulation of FcεR expressing cells, releasing itch factors. These factors -enzymes and cytokines can trigger eye rubbing and degranulated factors along with mechanical force of eye rubbing can have an effect on epithelium, keratocytes and fibroblasts of cornea resulting in an inflammatory molecular milieu contributing to dysregulated focal ECM remodeling resulting in keratoconus pathogenesis

Click here to view

Conjunctival biopsies from ocular allergy exhibits several degranulating mast cells and infiltration of inflammatory cells.[50] Since, mast activation results in the production of cytokines that facilitates immune cell trafficking and further the release of potent inflammatory mediators.[30],[51],[52] The eye rubbing in response to itchy eyes has been suggested as an important link between KC and allergy.[53] Such itch sensations are often mediated by inflammatory or immune factors that stimulate the release of itch factors. Therefore, it is possible that an allergy and immune mediated release of itch factors is causal in KC. Although, it is not understood whether the eye rubbing alone can initiate or worsen KC directly due to mechanical trauma, or if the inflammation due to subclinical ocular allergy causes the eye rubbing and consequently KC.[3] Elevated serum IgE levels in patients with allergy triggers the release of mediators such as histamine and IL-13, which activate transient receptor potential channels on sensory nerve endings to trigger an itch response.[54] Thus, in patients with clinical or subclinical ocular allergy, elevated serum IgE levels can be associated with KC, particularly those who have ocular surface inflammation or eye rubbing. Studies demonstrate that tear levels of matrix metalloproteinases (MMP)-13, IL-6, and TNF- alpha have been increased by eye rubbing even in normal eyes,[12],[53] suggesting an inflammation mediated mechanism linking eye rubbing with KC. More recently, the activation of FcεR on the peripheral nociceptive neurons by IgE-IC was reported to result in an itch response.[49]

Cytokines related to ocular allergy has been reviewed extensively elsewhere,[55] and IL-4, IL-5, and IL-13 are the common cytokines that was reported to be elevated in the different forms of ocular allergy. A variety of cytokines, including IL-1β, IL-4, IL-5, IL-6, IL-8, IL-13, IL-17, TNFα, IFNγ, chemokines, and MMPs was observed to elevated in the tears and ocular surface of KC patients.[47],[56],[57],[58],[59],[60],[61] In addition, increased proteolytic, gelatinolytic, and collagenolytic activity was also observed in the tears of KC patients.[62] Inflammatory mediators are also known to be associated with KCand could be driving the underlying inflammatory pathology.[46],[53],[63] These inflammatory signals also lead to an increase in the tissue protease activity and progression in KC, which is evidenced by the severity dependent increase in MMP9.[46],[54] In addition, KC corneas show altered collagen arrangement and extracellular matrix properties, which is suggested to be due to increased expression of lysosomal and proteolytic enzymes and decreased concentration of protease inhibitors.[53] While, IL-17 is known to induce MMP9,[64],[65] TNFα reduces collagen synthesis and lysyl oxidase (LOX) expression.[66],[67] Reduced LOX expression in the corneal epithelium was reported to be associated with sub-optimal outcome following cross-linking in KC patients.[68] Hence, inflammation associated increase in MMPs and decrease in LOX have resulted in compromised extra cellular matrix (ECM) remodeling (increased degradation and reduced synthesis of collagen), plausibly resulting in corneal ectasia.

  Emerging Perspectives in the Management of KC Top

Various strategies for the treatment of KC have been comprehensively reviewed in existing literature.[69] Most often, the management options are based on the grade of KC, which includes topography and pachymetry. An important adjunct to the the success of these treatment strategies relies on careful identification and the management of the associated risk factors. Allergy, atopy, and eye rubbing are key modifiable risk factors that would impact KC prognosis and treatment outcomes. Hence, we propose an addendum [Figure 2] to the currently available and preferred practice algorithms for KC. Since, IgE mediated factors like allergy and eye rubbing are evolving to be key drivers of KC pathogenesis, one approach to the management of KC could be to objectively identify and manage allergy and altered IgE status in KC patients to slow the progression of disease and improve the clinical outcome of surgical interventions. KC patients with associated allergy are more likely to have progressive KC and complications like acute hydrops due to the associated inflammation and eye rubbing.[17] Since, IgE levels correlate with the increasing grades of KC,[70] it is important to control the ocular and systemic allergy adequately. Controlling allergy may lead to reduced eye rubbing and the associated inflammation of the ocular surface. Therefore, controlling the ocular allergy along with systemic allergy could help attain better treatment outcomes. The management of ocular and systemic allergy would depend upon the severity, duration, and the frequency of episodes. The symptoms, depending on systemic involvement, like that of nose (allergic rhinitis) or that of lung (asthma) needs a multi-centric approach. It involves local therapy like intranasal steroids/decongestants/antihistamines or inhalers accordingly, or systemic antihistamines, leukotriene receptor antagonists, respectively.[71] Environmental avoidance measures, once a triggering allergen, is identified, is known to reduce the exacerbations.[71] High serum IgE, though the indicative of higher sensitization for atopy, warrants detailed systemic evaluation and the possible identification of locally relevant common allergens.[71]
Figure 2: Algorithm for clinical management of Keratoconus, raised IgE and Allergy. The relationship between allergy and KC is important in KC management. Treatment planning involves triaging KC patients based on allergy signs, history and eye rubbing. A multidisciplinary team with an immunologist is useful in patients with recurrent, severe allergy or history of atopy. Identification of allergen (skin prick or patch test; allergen specific IgE) and control (sublingual immunotherapy; avoidance of exposure) is possible. Total IgE status aids as well. Reducing ocular surface inflammation, IgE and induced effectors prior to treatment would improve outcome. Ag – Antigen/Allergen

Click here to view

The approach to allergic eye disease is targeted at the pathomechanism of the disease. Seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) are IgE mediated reactions to allergens.[72] Targeting IgE, IL-4, and IL-13 by using monoclonal antibodies (mAb, e.g. anti-IgE antibody, Omalizumab) against these factors, mast cell stabilizing agents, antihistaminics and steroids have been successful in the management of systemic allergy and atopic conditions. In the event of KC associated with severe/frequent ocular allergy or the history of systemic allergy, measurement of allergen specific IgE would be useful in identification of the trigger. Allergen specific immunotherapy (SIT) is a treatment recommended by the World Health Organization as an important addition to existing management protocols for severe allergy. Sublingual immunotherapy (SLIT) is a relatively new technique of immunotherapy to reduce the specific IgE load, which has been found to have high safety and efficacy. It works by making the patient more tolerant to the allergen, giving symptomatic relief, and reducing the need for medications especially steroids. An immunologist consultation for these patients would improve effectiveness in diagnosis and managing these subjects. SLIT has been found to be useful in treating patients with recalcitrant or chronic allergy not responding to regular treatment. It changes the phenotype of T cells from Th2 to Th1 as happens in when anergy or tolerance develops as a natural course of the disease.[72],[73] More severe cases or acute exacerbations can be treated when topical steroids are used in pulsed and tapering fashion. The type of topical steroid would again depend upon the severity of disease and can range from loteprednolol 0.5% to prednisolone 1% eye drops for varying frequencies and durations. The biggest drawback of using topical steroids are the potential side effects of long-term usage like rise in intraocular pressure and cataract formation. To avoid such complications, there are steroid sparing agents like cyclosporine 0.05% and 0.1% eye drops and tacrolimus 0.03% and 0.1% eye ointment, which act by calcineurin inhibition.[74],[75]

Topical mast cell stabilizers like sodium cromoglycate and anti-histamines, either alone or in combination can be effective in the managing milder/moderate form of allergies and eye rubbing. Mast cell stabilizers act primarily by stabilizing mast cell membranes and inhibiting degranulation, thereby preventing histamine release. They prevent the signs and symptoms of type 1 allergic reactions including acute and chronic allergic conjunctivitis.[76] Newer molecules like olopatadine have a dual mode of action by both mast cell stabilization and antihistaminic action. It inhibits the release of histamine, tryptase, and PGD2 with decreased H1 receptor binding activity in vitro. Another possible method of action is by inhibiting anti-IgE antibody-mediated release of tumor necrosis factor alpha (TNFα) from human conjunctival mast cells, which plays an important role in allergic ocular inflammation via increasing intercellular adhesion molecule (ICAM)-1 on epithelial cells and triggering other proinflammatory events. These medications are effective as a stand-alone medication in milder ocular allergy and as an adjunct in more acute allergy with topical steroids.[77],[78]

  Conclusion Top

Since KC is often associated with allergy and eye rubbing, it is important to control allergy while treating the KC. Measuring serum IgE could be an important parameter in the management of KC especially if the patient has chronic ocular allergy and is a frequent eye rubber. However, in certain patients, the serum IgE may be elevated even without any symptoms or signs, thereby making IgE testing relevant even in such cases. The inflammation induced extracellular remodeling associated with KC may therefore be reduced if the allergy or IgE induced inflammatory stimulus is controlled medically. However, the cost of doing the serum specific IgE test is a limitation as it may not be affordable for many patients. With advancing technologies and the use of tear fluid, a more affordable and non invasive means to assess IgE status would be possible to aid informed decision making in the management of KC.


Narayana Nethralaya Foundation, Bangalore, India.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol 1984;28:293-322.  Back to cited text no. 1
Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998;42:297-319.  Back to cited text no. 2
Naderan M, Rajabi MT, Zarrinbakhsh P, Bakhshi A. Effect of allergic diseases on keratoconus severity. Ocul Immunol Inflamm 2017;25:418-23.  Back to cited text no. 3
Romero-Jimenez M, Santodomingo-Rubido J, Wolffsohn JS. Keratoconus: Areview. Cont Lens Anterior Eye 2010;33:157-66.  Back to cited text no. 4
Sharma N, Rao K, Maharana PK, Vajpayee RB. Ocular allergy and keratoconus. Indian J Ophthalmol 2013;61:407-9.  Back to cited text no. 5
  [Full text]  
Shetty R, Sureka S, Kusumgar P, Sethu S, Sainani K. Allergen-specific exposure associated with high immunoglobulin E and eye rubbing predisposes to progression of keratoconus. Indian J Ophthalmol 2017;65:399-402.  Back to cited text no. 6
[PUBMED]  [Full text]  
Rahi A, Davies P, Ruben M, Lobascher D, Menon J. Keratoconus and coexisting atopic disease. Br J Ophthalmol 1977;61:761-4.  Back to cited text no. 7
Kemp EG, Lewis CJ. Immunoglobulin patterns in keratoconus with particular reference to total and specific IgE levels. Br J Ophthalmol 1982;66:717-20.  Back to cited text no. 8
Zadnik K, Barr JT, Edrington TB, Everett DF, Jameson M, McMahon TT, et al. Baseline findings in the collaborative longitudinal evaluation of keratoconus (CLEK) study. Invest Ophthalmol Vis Sci 1998;39:2537-46.  Back to cited text no. 9
Bawazeer AM, Hodge WG, Lorimer B. Atopy and keratoconus: Amultivariate analysis. Br J Ophthalmol 2000;84:834-6.  Back to cited text no. 10
Weed KH, MacEwen CJ, Giles T, Low J, McGhee CN. The Dundee University Scottish Keratoconus study: Demographics, corneal signs, associated diseases, and eye rubbing. Eye (Lond) 2008;22:534-41.  Back to cited text no. 11
Agrawal VB. Characteristics of keratoconus patients at a tertiary eye center in India. J Ophthalmic Vis Res 2011;6:87-91.  Back to cited text no. 12
  [Full text]  
Cingu AK, Cinar Y, Turkcu FM, Sahin A, Ari S, Yuksel H, et al. Effects of vernal and allergic conjunctivitis on severity of keratoconus. Int J Ophthalmol 2013;6:370-4.  Back to cited text no. 13
Najmi H, Mobarki Y, Mania K, Altowairqi B, Basehi M, Mahfouz MS, et al. The correlation between keratoconus and eye rubbing: Areview. Int J Ophthalmol 2019;12:1775-81.  Back to cited text no. 14
Hashemi H, Heydarian S, Hooshmand E, Saatchi M, Yekta A, Aghamirsalim M, et al. The Prevalence and risk factors for keratoconus: A systematic review and meta-analysis. Cornea 2020;39:263-70.  Back to cited text no. 15
Sharma R, Titiyal JS, Prakash G, Sharma N, Tandon R, Vajpayee RB. Clinical profile and risk factors for keratoplasty and development of hydrops in north Indian patients with keratoconus. Cornea 2009;28:367-70.  Back to cited text no. 16
El Rami H, Chelala E, Dirani A, Fadlallah A, Fakhoury H, Cherfan C, et al. An update on the safety and efficacy of corneal collagen cross-linking in pediatric keratoconus. Biomed Res Int 2015;2015:257927.  Back to cited text no. 17
Yildiz EH, Erdurmus M, Hammersmith KM, Rapuano CJ, Laibson PR, Cohen EJ. Comparative study of graft rejection in keratoconus patients with and without self-reported atopy. Cornea 2009;28:846-50.  Back to cited text no. 18
Neira W, Krootila K, Holopainen JM. Atopic dermatitis is a risk factor for intracorneal ring segment extrusion. Acta Ophthalmol 2014;92:e491-2.  Back to cited text no. 19
Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term results. J Cataract Refract Surg 2008;34:796-801.  Back to cited text no. 20
Peyman A, Kamali A, Khushabi M, Nasrollahi K, Kargar N, Taghaodi M, et al. Collagen cross-linking effect on progressive keratoconus in patients younger than 18 years of age: A clinical trial. Adv Biomed Res 2015;4:245.  Back to cited text no. 21
[PUBMED]  [Full text]  
Antoun J, Slim E, El Hachem R, Chelala E, Jabbour E, Cherfan G, et al. Rate of corneal collagen crosslinking redo in private practice: Risk factors and safety. J Ophthalmol 2015;2015:690961.  Back to cited text no. 22
Egrilmez S, Sahin S, Yagci A. The effect of vernal keratoconjunctivitis on clinical outcomes of penetrating keratoplasty for keratoconus. Can J Ophthalmol 2004;39:772-7.  Back to cited text no. 23
Thomas JK, Guel DA, Thomas TS, Cavanagh HD. The role of atopy in corneal graft survival in keratoconus. Cornea 2011;30:1088-97.  Back to cited text no. 24
Leonardi A, Bogacka E, Fauquert JL, Kowalski ML, Groblewska A, Jedrzejczak-Czechowicz M, et al. Ocular allergy: Recognizing and diagnosing hypersensitivity disorders of the ocular surface. Allergy 2012;67:1327-37.  Back to cited text no. 25
Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2010;125 (2 Suppl 2):S73-80.  Back to cited text no. 26
Leonardi A, Motterle L, Bortolotti M. Allergy and the eye. Clin Exp Immunol 2008;153(Suppl 1):17-21.  Back to cited text no. 27
Kemp EG, Lewis CJ. Measurement of total and specific IgE levels in the management of a family exhibiting a high incidence of keratoconus. Acta Ophthalmol (Copenh) 1984;62:524-9.  Back to cited text no. 28
Harrison RJ, Klouda PT, Easty DL, Manku M, Charles J, Stewart CM. Association between keratoconus and atopy. Br J Ophthalmol 1989;73:816-22.  Back to cited text no. 29
Wakamatsu TH, Satake Y, Igarashi A, Dogru M, Ibrahim OM, Okada N, et al. IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. Br J Ophthalmol 2012;96:581-6.  Back to cited text no. 30
Leonardi A. Allergy and allergic mediators in tears. Exp Eye Res 2013;117:106-17.  Back to cited text no. 31
Dermer H, Theotoka D, Lee CJ, Chhadva P, Hackam AS, Galor A, et al. Total tear IgE levels correlate with allergenic and irritating environmental exposures in individuals with dry eye. J Clin Med 2019;8.  Back to cited text no. 32
Shetty R, Naidu JR, Nair AP, Vaidya TA, D'Souza S, Matalia H, et al. Distinct ocular surface soluble factor profile in human corneal dystrophies. Ocul Surf 2019. doi: 10.1016/j.jtos. 2019.11.007.  Back to cited text no. 33
Gasset AR, Hinson WA, Frias JL. Keratoconus and atopic diseases. Ann Ophthalmol 1978;10:991-4.  Back to cited text no. 34
Mimura T, Usui T, Yamagami S, Miyai T, Amano S. Relation between total tear IgE and severity of acute seasonal allergic conjunctivitis. Curr Eye Res 2012;37:864-70.  Back to cited text no. 35
Mimura T, Yamagami S, Kamei Y, Goto M, Matsubara M. Specific IgE in tear fluid and features of allergic conjunctivitis. Curr Eye Res 2013;38:917-25.  Back to cited text no. 36
Mimura T, Usui T, Yamagami S, Miyai T, Amano S. Relationship between total tear IgE and specific serum IgE in autumnal allergic conjunctivitis. Cornea 2013;32:14-9.  Back to cited text no. 37
Ueta M, Shoji J, Sotozono C, Kinoshita S. Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. Clin Transl Allergy 2014;4:40.  Back to cited text no. 38
Mimura T, Usui T, Mori M, Funatsu H, Noma H, Yamamoto H, et al. Relationship between total tear and serum IgE in allergic conjunctivitis. Int Arch Allergy Immunol 2011;154:349-52.  Back to cited text no. 39
Mimura T, Usui T, Mori M, Funatsu H, Noma H, Yamamoto H, et al. Relation between total tear IgE and specific serum IgE in seasonal allergic conjunctivitis. Cornea 2011;30:790-5.  Back to cited text no. 40
Mimura T, Yamagami S, Noma H, Kamei Y, Goto M, Kondo A, et al. Specific IgE for wheat in tear fluid of patients with allergic conjunctivitis. Cutan Ocul Toxicol 2015;34:25-34.  Back to cited text no. 41
Abdel-Latif RS, ELBadawy NE, Ibrahim BM. Ibrahim, validity of specific immunoglobulin E assay in tear film for detection of allergens inducing different types of allergic conjunctivitis. Egypt J Immunol 2017;24:127-40.  Back to cited text no. 42
Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera A. Keratoconus: An inflammatory disorder? Eye (Lond) 2015;29:843-59.  Back to cited text no. 43
Shetty R, Sathyanarayanamoorthy A, Ramachandra RA, Arora V, Ghosh A, Srivatsa PR, et al. Attenuation of lysyl oxidase and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity. Mol Vis 2015;21:12-25.  Back to cited text no. 44
Shetty R, Ghosh A, Lim RR, Subramani M, Mihir K, Reshma AR, et al. Elevated expression of matrix metalloproteinase-9 and inflammatory cytokines in keratoconus patients is inhibited by cyclosporine A. Invest Ophthalmol Vis Sci 2015;56:738-50.  Back to cited text no. 45
Pahuja N, Kumar NR, Shroff R, Shetty R, Nuijts RM, Ghosh A, et al. Differential molecular expression of extracellular matrix and inflammatory genes at the corneal cone apex drives focal weakening in keratoconus. Invest Ophthalmol Vis Sci 2016;57:5372-82.  Back to cited text no. 46
Shetty R, Deshmukh R, Ghosh A, Sethu S, Jayadev C. Altered tear inflammatory profile in Indian keratoconus patients-The 2015 col rangachari award paper. Indian J Ophthalmol 2017;65:1105-8.  Back to cited text no. 47
[PUBMED]  [Full text]  
Untersmayr E, Bises G, Starkl P, Bevins CL, Scheiner O, Boltz-Nitulescu G, et al. The high affinity IgE receptor Fc epsilonRI is expressed by human intestinal epithelial cells. PLoS One, 2010. 5:e9023.  Back to cited text no. 48
Liu F, Xu L, Chen N, Zhou M, Li C, Yang Q, et al. Neuronal Fc-epsilon receptor I contributes to antigen-evoked pruritus in a murine model of ocular allergy. Brain Behav Immun 2017;61:165-75.  Back to cited text no. 49
Easty DL, Birkenshaw M, Merrett T, Merrett J, Entwhistle C, Amer B. Immunological investigations in vernal eye disease. Trans Ophthalmol Soc UK 1980;100:98-107.  Back to cited text no. 50
Graziano FM, Stahl JL, Cook EB, Barney NP. Conjunctival mast cells in ocular allergic disease. Allergy Asthma Proc 2001;22:121-6.  Back to cited text no. 51
Elieh Ali Komi D, Rambasek T, Bielory L. Clinical implications of mast cell involvement in allergic conjunctivitis. Allergy 2018;73:528-39.  Back to cited text no. 52
Balasubramanian SA, Pye DC, Willcox MD. Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: Relevance in keratoconus. Clin Exp Optom 2013;96:214-8.  Back to cited text no. 53
Kittaka H, Tominaga M. The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin. Allergol Int 2017;66:22-30.  Back to cited text no. 54
Aydin E, Gokhale M, Azizoglu S, Suphioglu C. To See or not to see: A systematic review of the importance of human ocular surface cytokine biosignatures in ocular allergy. Cells 2019;8. doi: 10.3390/cells8060620.  Back to cited text no. 55
Lema I, Duran JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology 2005;112:654-9.  Back to cited text no. 56
Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, et al. Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS One 2011;6:e16437.  Back to cited text no. 57
Kolozsvári BL, Petrovski G, Gogolák P, Rajnavölgyi É, Tóth F, Berta A, et al. Association between mediators in the tear fluid and the severity of keratoconus. Ophthalmic Res 2014;51:46-51.  Back to cited text no. 58
Wisse RP, Kuiper JJ, Gans R, Imhof S, Radstake TR, Van der Lelij A, et al. Cytokine expression in keratoconus and its corneal microenvironment: A systematic review. Ocul Surf 2015;13:272-83.  Back to cited text no. 59
Sorkhabi R, Ghorbanihaghjo A, Taheri N, Ahoor MH. Tear film inflammatory mediators in patients with keratoconus. Int Ophthalmol 2015;35:467-72.  Back to cited text no. 60
Ionescu IC, Corbu CG, Tanase C, Ionita G, Nicula C, Coviltir V, et al. Overexpression of tear inflammatory cytokines as additional finding in keratoconus patients and their first degree family members. Mediators Inflamm 2018;2018:4285268.  Back to cited text no. 61
Balasubramanian SA, Mohan S, Pye DC, Willcox MD. Proteases, proteolysis and inflammatory molecules in the tears of people with keratoconus. Acta Ophthalmol 2012;90:e303-9.  Back to cited text no. 62
Nemet AY, Vinker S, Bahar I, Kaiserman I. The association of keratoconus with immune disorders. Cornea 2010;29:1261-4.  Back to cited text no. 63
De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD 3rd, Fang B, Zheng X, et al. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol 2009;2:243-53.  Back to cited text no. 64
Hou A, TongL. Expression, regulation, and effects of interleukin-17f in the human ocular surface. Ocul Immunol Inflamm 2018;26:1069-77.  Back to cited text no. 65
Greenwel P, Tanaka S, Penkov D, Zhang W, Olive M, Moll J, et al. Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT/enhancer-binding proteins. Mol Cell Biol 2000;20:912-8.  Back to cited text no. 66
Rodríguez C, Alcudia JF, Martínez-González J, Raposo B, Navarro MA, Badimon L. Lysyl oxidase (LOX) down-regulation by TNFalpha: Anew mechanism underlying TNFalpha-induced endothelial dysfunction. Atherosclerosis 2008;196:558-64.  Back to cited text no. 67
Shetty R, Rajiv Kumar N, Pahuja N, Deshmukh R, Vunnava K, Abilash VG, et al. Outcomes of corneal cross-linking correlate with cone-specific lysyl oxidase expression in patients with keratoconus. Cornea 2018;37:369-74.  Back to cited text no. 68
Andreanos KD, Hashemi K, Petrelli M, Droutsas K, Georgalas I, Kymionis GD. Keratoconus Treatment Algorithm. Ophthalmol Ther 2017;6:245-62.  Back to cited text no. 69
Patel P, Shetty R, Ghosh A, Sethu S, Khamar P, Ahuja P, Ocular surface immune trafficking and eye rubbing in keratoconus, and its impact on treatment outcomes, in International CXL Experts; Meeting. 2018: Zurich, Switzerland.  Back to cited text no. 70
Dhami S, Nurmatov U, Roberts G, Pfaar O, Muraro A, Ansotegui IJ, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: Protocol for a systematic review. Clin Transl Allergy 2016;6:12.  Back to cited text no. 71
Kari O, Saari KM. Updates in the treatment of ocular allergies. J Asthma Allergy 2010;3:149-58.  Back to cited text no. 72
Frati F, Scurati S, Puccinelli P, David M, Hilaire C, Capecce M, et al. Development of a sublingual allergy vaccine for grass pollinosis. Drug Des Devel Ther 2010;4:99-105.  Back to cited text no. 73
Ebihara N, Ohashi Y, Uchio E, Okamoto S, Kumagai N, Shoji J, et al. A large prospective observational study of novel cyclosporine 0.1% aqueous ophthalmic solution in the treatment of severe allergic conjunctivitis. J Ocul Pharmacol Ther 2009;25:365-72.  Back to cited text no. 74
Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y, et al. A randomized, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis. J Ocul Pharmacol Ther 2010;26:165-74.  Back to cited text no. 75
Sorkin EM, Ward A. Ocular sodium cromoglycate. An overview of its therapeutic efficacy in allergic eye disease. Drugs 1986;31:131-48.  Back to cited text no. 76
Gonzalez-Estrada A, Reddy K, Dimov V, Eidelman F. Olopatadine hydrochloride ophthalmic solution for the treatment of allergic conjunctivitis. Expert Opin Pharmacother 2017;18:1137-43.  Back to cited text no. 77
Cook EB, Stahl JL, Barney NP, Graziano FM. Olopatadine inhibits TNFalpha release from human conjunctival mast cells. Ann Allergy Asthma Immunol 2000;84:504-8.  Back to cited text no. 78
Brunsting LA, Reed WB, Bair HL. Occurrence of cataracts and keratoconus with atopic dermatitis. AMA Arch Derm 1955;72:237-41.  Back to cited text no. 79
Galin MA, Berger R. Atopy and keratoconus. Am J Ophthalmol 1958;45:904-6.  Back to cited text no. 80
Ring CC. Atopic dermatitis with cataracts; a report of three cases, one with keratoconus. Trans Ophthalmol Soc N Z 1958;10:41-7.  Back to cited text no. 81
Spencer WH, FisherJJ. The association of keratoconus with atopic dermatitis. Am J Ophthalmol 1959;47:332-44.  Back to cited text no. 82
Copeman PW. Eczema and keratoconus. Br Med J 1965;2:977-9.  Back to cited text no. 83
Lowell FC, Carroll JM.A study of the occurrence of atopic traits in patients with keratoconus. J Allergy 1970;46:32-9.  Back to cited text no. 84
Longmore L. Atopic dermatitis cataract and keratoconus. Australas J Dermatol 1970;11:139-41.  Back to cited text no. 85
Wachtmeister L, Ingemansson SO, Moller E. Atopy and HLA antigens in patients with keratoconus. Acta Ophthalmol (Copenh) 1982;60:113-22.  Back to cited text no. 86
Tuft SJ, Moodaley LC, Gregory WM, Davison CR, Buckley RJ. Prognostic factors for the progression of keratoconus. Ophthalmology 1994;101:439-47.  Back to cited text no. 87
Reinhard T, Moller M, Sundmacher R. Penetrating keratoplasty in patients with atopic dermatitis with and without systemic cyclosporin A. Cornea 1999;18:645-51.  Back to cited text no. 88
Hollingsworth JG, Efron N, Tullo AB. In vivo corneal confocal microscopy in keratoconus. Ophthalmic Physiol Opt 2005;25:254-60.  Back to cited text no. 89
Watson SL, Tuft SJ, Dart JK. Patterns of rejection after deep lamellar keratoplasty. Ophthalmology 2006;113:556-60.  Back to cited text no. 90
Kaya V, Karakaya M, Utine CA, Albayrak S, Oge OF, Yilmaz OF. Evaluation of the corneal topographic characteristics of keratoconus with orbscan II in patients with and without atopy. Cornea 2007;26:945-8.  Back to cited text no. 91
Millodot M, Shneor E, Albou S, Atlani E, Gordon-Shaag A. Prevalence and associated factors of keratoconus in Jerusalem: Across-sectional study. Ophthalmic Epidemiol 2011;18:91-7.  Back to cited text no. 92
Saboo US, Jain M, Reddy JC, Sangwan VS. Demographic and clinical profile of vernal keratoconjunctivitis at a tertiary eye care center in India. Indian J Ophthalmol 2013;61:486-9.  Back to cited text no. 93
[PUBMED]  [Full text]  
Nivenius E, Montan P. Spontaneous corneal perforation associated with atopic keratoconjunctivitis: Acase series and literature review. Acta Ophthalmol 2015;93:383-7.  Back to cited text no. 94
Merdler I, Hassidim A, Sorkin N, Shapira S, Gronovich Y, Korach Z. Keratoconus and allergic diseases among Israeli adolescents between 2005 and 2013. Cornea 2015;34:525-9.  Back to cited text no. 95
Shajari M, Eberhardt E, Müller M, Al Khateeb G, Friderich S, Remy M, et al. Effects of atopic syndrome on keratoconus. Cornea 2016;35:1416-20.  Back to cited text no. 96
Antonios R, Dirani A, Fadlallah A, Chelala E, Hamadeh A, Jarade E. Acute corneal hydrops 3 years after intra-corneal ring segments and corneal collagen cross-linking. Middle East Afr J Ophthalmol 2016;23:156-9.  Back to cited text no. 97
[PUBMED]  [Full text]  
Thyssen JP, Toft PB, Halling-Overgaard AS, Gislason GH, Skov L, Egeberg A. Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. J Am Acad Dermatol 2017;77:280-286 e1.  Back to cited text no. 98
Mazzotta C, Traversi C, Mellace P, Bagaglia SA, Zuccarini S, Mencucci R, et al., Keratoconus progression in patients with allergy and elevated surface matrix metalloproteinase 9 point-of-care test. Eye Contact Lens 2018;44(Suppl 2):S48-53.  Back to cited text no. 99
Lee HK, Jung EH, Cho BJ. Epidemiological association between systemic diseases and keratoconus in a Korean population: A 10-year nationwide cohort study. Cornea 2020;39:348-53.  Back to cited text no. 100
Bak-Nielsen S, Ramlau-Hansen CH, Ivarsen A, Plana-Ripoll O, Hjortdal J. A nationwide population-based study of social demographic factors, associated diseases and mortality of keratoconus patients in Denmark from 1977 to 2015. Acta Ophthalmol 2019;97:497-504.  Back to cited text no. 101
Alrobaian M, Elsayed M, Alotaibi AK, AlHarbi M, May W, Stone DU. Safety and efficacy of corneal cross-linking in pediatric patients with keratoconus and vernal keratoconjunctivitis. Middle East Afr J Ophthalmol 2019;26:95-100.  Back to cited text no. 102
[PUBMED]  [Full text]  
Easty D, Entwistle C, Funk A, Witcher J. Herpes simplex keratitis and keratoconus in the atopic patient. A clinical and immunological study. Trans Ophthalmol Soc U K 1975;95:267-76.  Back to cited text no. 103
Kim J, Netto MV. Keratoconus associated with hyperimmunoglobulin E syndrome. Cornea 2004;23:93-6.  Back to cited text no. 104
Kodama R, Yang X, Araki T, Sato M, Iwashige S, Tanigawa Y, et al. Keratoconus in a cynomolgus monkey. J Toxicol Pathol 2010;23:53-8.  Back to cited text no. 105


  [Figure 1], [Figure 2]

  [Table 1], [Table 2]

This article has been cited by
1 March consultation #10
Rohit Shetty, Pooja Khamar, Gairik Kundu, Arkasubhra Ghosh, Swaminathan Sethu
Journal of Cataract and Refractive Surgery. 2023; 47(3): 159
[Pubmed] | [DOI]
2 Keratoconus: An updated review
Jacinto Santodomingo-Rubido, Gonzalo Carracedo, Asaki Suzaki, Cesar Villa-Collar, Stephen J. Vincent, James S. Wolffsohn
Contact Lens and Anterior Eye. 2022; : 101559
[Pubmed] | [DOI]
3 Características clínico-epidemiológicas del queratocono en Asturias
K. Fernández Berdasco, L.B. Alfaya Muñoz, C.R. Corzo Fernández, A. Señaris González, B. Baamonde Arbaiza
Archivos de la Sociedad Española de Oftalmología. 2022;
[Pubmed] | [DOI]
4 Clinical-epidemiological characteristics of keratoconus in Asturias
K. Fernández Berdasco, L.B. Alfaya Muñoz, C.R. Corzo Fernández, A. Señaris González, B. Baamonde Arbaiza
Archivos de la Sociedad Española de Oftalmología (English Edition). 2022;
[Pubmed] | [DOI]
5 The association between keratoconus and allergic eye diseases: A systematic review and meta-analysis
Ishith Seth, Gabriella Bulloch, Michael Vine, Joseph Outmezguine, Nimish Seth, James Every, Mark Daniell
Clinical & Experimental Ophthalmology. 2022; 47(3): 423
[Pubmed] | [DOI]
6 Identification of Key Genes and Molecular Pathways in Keratoconus: Integrating Text Mining and Bioinformatics Analysis
Di Hu, Zenan Lin, Junhong Jiang, Pan Li, Zhehuan Zhang, Chenhao Yang, Shibiao Wan
BioMed Research International. 2022; 2022: 1
[Pubmed] | [DOI]
7 Research Progress on Non-Hereditary Etiology of Keratoconus
?? ?
Hans Journal of Ophthalmology. 2022; 11(01): 83
[Pubmed] | [DOI]
8 Family-based exome sequencing identifies candidate genes related to keratoconus in Chinese families
Liyan Xu, Kaili Yang, Shanshan Yin, Yuwei Gu, Qi Fan, Yawen Wang, Dongqing Zhao, Shengwei Ren
Frontiers in Genetics. 2022; 13
[Pubmed] | [DOI]
9 Choroidal thickness assessment in keratoconus patients treated with cross-linking compared to healthy population
Antonio Ballesteros-Sánchez, Concepción De-Hita-Cantalejo, María Carmen Sánchez-González, María-José Bautista-Llamas, José-María Sánchez-González, Beatriz Gargallo-Martínez
International Ophthalmology. 2022;
[Pubmed] | [DOI]
10 Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile
Sharon D’Souza, Archana Padmanabhan Nair, Ganesh Ram Sahu, Tanuja Vaidya, Rohit Shetty, Pooja Khamar, Ritika Mullick, Sneha Gupta, Mor M. Dickman, Rudy M. M. A. Nuijts, Rajiv R. Mohan, Arkasubhra Ghosh, Swaminathan Sethu
Scientific Reports. 2021; 11(1)
[Pubmed] | [DOI]
11 Biochemical Markers and Alterations in Keratoconus
Rohit Shetty, Sharon D'Souza, Pooja Khamar, Arkasubhra Ghosh, Rudy M.M.A. Nuijts, Swaminathan Sethu
Asia-Pacific Journal of Ophthalmology. 2020; 9(6): 533
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Allergy, Atopy, ...
Serum Ige and KC
Tear Ige and KC
Ige Associated K...
Emerging Perspec...
Article Figures
Article Tables

 Article Access Statistics
    PDF Downloaded265    
    Comments [Add]    
    Cited by others 11    

Recommend this journal