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Year : 2020  |  Volume : 68  |  Issue : 11  |  Page : 2439-2444

Hypochlorous acid antiseptic washout improves patient comfort after intravitreal injection: A patient reported outcomes study

The New York Eye Cancer Center, New York, New York, USA

Correspondence Address:
Paul T Finger
MD, The New York Eye Cancer Center, Fifth Floor, 115 East 61st Street, New York, NY 10065
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_2001_20

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Purpose: Current ocular antiseptic practice for intravitreal injection (IVI) employs 5% povidone–iodine (Betadine®) drops which frequently cause ocular discomfort and prolonged irritation. In an effort to improve comfort while maintaining efficacy, we studied a hypochlorous acid (HOCL 0.01%) spray washout prior to injection. Methods: Patients had received a minimum of 3 IVIs prepared with Betadine®antisepsis prior to entry in this study. Their subsequent IVIs were prepared with Betadine®followed by HOCL 0.01% washout. Facets of comfort were measured by a Likert-scaled questionnaire to compare their experiences after IVI. Results: Thirty-seven participants were enrolled. Addition of HOCL 0.01% spray after Betadine®reduced the duration of discomfort (P = 0.001) and need for artificial tears postinjection (P = 0.003). It improved their reported quality of life (P = 0.04) and sleep (P = 0.01). There were neither HOCL-related side effects nor endophthalmitis during this study. Conclusion: Topical HOCL 0.01% spray after topical Betadine®antisepsis significantly improved patient comfort following IVIs.

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