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   Table of Contents      
OPHTHALMIC IMAGE
Year : 2020  |  Volume : 68  |  Issue : 11  |  Page : 2534

Cherubism with orbital involvement


1 Department of Ophthalmology, Virgen de las Nieves University Hospital; Doctoral Programme in Clinical Medicine and Public Health, University of Granada, Granada, Spain Hospital Virgen de las Nieves, c/Av. de las Fuerzas Armadas, 2, 18014 Granada, Spain
2 Department of Ophthalmology, Virgen de las Nieves University Hospital, 18014 Granada, Spain

Date of Web Publication26-Oct-2020

Correspondence Address:
Dr. Javier Lacorzana
c/ Av. de las Fuerzas Armadas, 2,18014, Granada
Spain
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_870_20

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How to cite this article:
Lacorzana J, Prieto-Moreno CG. Cherubism with orbital involvement. Indian J Ophthalmol 2020;68:2534

How to cite this URL:
Lacorzana J, Prieto-Moreno CG. Cherubism with orbital involvement. Indian J Ophthalmol [serial online] 2020 [cited 2020 Nov 28];68:2534. Available from: https://www.ijo.in/text.asp?2020/68/11/2534/299115



A 13-year-old boy, diagnosed with cherubism, had mild exophthalmos and visual acuity (VA) 0.9 on both eyes. Neuroimaging showed multiple cystic images that affected both maxillary and mandibular bones, sparing both mandibular condyles. Cystic formations involved the orbit, causing displacement of the extrinsic muscles and the eyeballs [Figure 1]. It was decided to monitor him due to the stability of the disease, the mild exophthalmos, the unaffected ocular mobility, and good VA. Cherubism usually starts affecting the jaw, second, the maxilla, and later it may extend to the orbit. Hence, it must be examined by an ophthalmologist to diagnose possible orbital manifestations.[1],[2],[3],[4],[5]
Figure 1: (a and b) Computed tomography (CT) 3D showed bilateral radiolucencies and multicystic lesions in the mandible, maxilla, and orbit. More marked injuries were on the left side. (c) CT Orbital invasion causing exophthalmos. The roofs of the orbits were preserved. (d) Asymmetrical cherubism; it was more marked on the left side. CT: Computed tomography

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Yoo SH, Pineles SL, Jarrahy R, Velez FG. Ophthalmic manifestations of cherubism. J AAPOS 2015;19:70-2.  Back to cited text no. 1
    
2.
Yu Z, Zhai M, Gan W, Zhang H, Zhou Y, Wen H. Cherubism with bilateral mandible and maxilla involvement: A case report. Medicine (Baltimore) 2015;94:e2120.  Back to cited text no. 2
    
3.
Robbins S, Kozak I. New retinal findings in cherubism. Retin Cases Brief Rep 2010;4:146-9.  Back to cited text no. 3
    
4.
Mirmohammadsadeghi A, Eshraghi B, Shahsanaei A, Assari R. Cherubism: Report of three cases and literature review. Orbit 2015;34:33-7.  Back to cited text no. 4
    
5.
Kadlub N, Sessiecq Q, Mandavit M, L'Hermine AC, Bandoual C, Galmiche L, et al. Molecular and cellular characterizations of human cherubism: Disease aggressiveness depends on osteoclast differentiation. Orphanet J Rare Dis 2018;13:166. [Figure 1]: (a and b) Computed tomography (CT) 3D showed bilateral radiolucencies and multicystic lesions in the mandible, maxilla, and orbit. More marked injuries were on the left side. (c) CT Orbital invasion causing exophthalmos. The roofs of the orbits were preserved. (d) Asymmetrical cherubism; it was more marked on the left side. CT: Computed tomography  Back to cited text no. 5
    


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