Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 5632
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 2020  |  Volume : 68  |  Issue : 1  |  Page : 123

Commentary: Pachydrusen: A tell-tale sign of pachychoroid phenotype

1 Retina Services, Kamalnayan Bajaj Sankara Nethralaya, New Town, Kolkata, West Bangal, India
2 Retina Services, B. B. Eye Foundation, Kolkata, West Bangal, India

Date of Web Publication19-Dec-2019

Correspondence Address:
Dr. Kumar Saurabh
Kamalnayan Bajaj Sankara Nethralaya, DJ16, Action Area 1D, New Town Kolkata - 700 156, West Bengal
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1534_19

Rights and Permissions

How to cite this article:
Saurabh K, Roy R. Commentary: Pachydrusen: A tell-tale sign of pachychoroid phenotype. Indian J Ophthalmol 2020;68:123

How to cite this URL:
Saurabh K, Roy R. Commentary: Pachydrusen: A tell-tale sign of pachychoroid phenotype. Indian J Ophthalmol [serial online] 2020 [cited 2021 Mar 3];68:123. Available from: https://www.ijo.in/text.asp?2020/68/1/123/273205

The pachychoroid phenotype encompasses changes in morphology of choroid which are physiological as well as pathological. The clinical characteristics of pachychoroid phenotype are reduced choroidal vascular markings in fundus, drusenoid retinal pigment epithelium (RPE) changes, and small pigment epithelium detachments.[1] These eyes have increased thickness of choroid on optical coherence tomography (OCT) and choroidal hyperpermeability on indocyanine green angiography.[1] Identifying such eyes is utmost important because they are prone to develop central serous chorioretinopathy (CSC), polypoidal choroidal vasculopathy, and sub-RPE neovascularization.[1],[2] Initially, a thick (pachy) choroid was considered as the cornerstone of pachychoroid phenotype which was defined as subfoveal choroidal thickness of >300 micron or extrafoveal focus of thick choroid exceeding subfoveal choroidal thickness by 50 micron or more.[3] With the evolution of our knowledge about pachychoroid, it is now believed that the total thickness of choroid was not the sole criterion to define pachychoroid phenotype and eyes with choroidal thickness less than 300 micron too could manifest pathological changes of diseases associated with pachychoroid. Cheung CMG et al. described that eyes with increased thickness of choroidal Haller's layer (pachy-vessel) and compression of overlying Sattler's layer and choriocapillaris develop changes in the RPE and were to be considered as pachychoroid phenotype.[4]

The understanding about pachychoroid spectrum of disorders is still evolving. It is obvious that swept-source OCT or spectral domain OCT with enhanced depth imaging was a prerequisite to identify these eyes. However, there are subtle clinical fundus findings, which help clinicians to think about the possibility of dealing with an eye with pachychoroid. Diffuse, focal or multifocal reddish-orange hue of the fundus, reduced choroidal vascular markings, and drusenoid RPE changes on posterior pole on indirect ophthalmoscopy are such signs suggesting a thicker choroid and probably pachychoroid phenotype.[1] Richard Spaide further elucidated the nature of these drusenoid RPE changes and explained them as drusen, which were different from those found in age-related macular degeneration.[5] He coined the term “pachydrusen” to describe drusen in pachychoroid eyes that were large (>125 micron) and were distributed over entire posterior pole, even around the optic disc. Unlike large soft drusen, pachydrusen had well defined and complex margins and could be found in isolation or clusters. Identifying pachydrusen on fundus should be a hint or tell-tale sign of underlying pachychoroid phenotype.

The authors in the published study (citation to be updated) report the prevalence of pachydrusen in CSC as 6.82% which is lower than the previous report from Japan.[6],[7] This variation could be due to demographic and ethnic differences of the study populations. This study carries it value for being the first from India to report the prevalence of pachydrusen in CSC. It is intriguing to note that the authors did not find any significant difference in subfoveal choroidal thickness among CSC eyes with and without pachydrusen because CSC can be seen in eyes with normal choroidal thickness as well. Further they did not find higher choroidal thickness at the site of pachydrusen compared to subfoveal choroidal thickness, which has recently been reported by Baek J et al.[8] In the present study, these findings have been obtained from small number of eyes with pachydrusen (nine out of 132 eyes). However, these findings still point toward a possible role of demographic variation in the choroidal morphology. The present study also reports pachydrusen as a feature of chronic, persistent or resolved CSC and not of acute CSC. It will be interesting to note pachydrusen in eyes with uncomplicated pachychoroid or pachychoroid pigment epitheliopathy which have not developed CSC. Similarly, a longitudinal study of pachydrusen in CSC will be able to shed light on their natural history, their influence on spontaneous resolution of CSC, as well as on the response to treatment.

  References Top

Warrow DJ, Hoang QV, Freund KB. Pachychoroid pigment epitheliopathy. Retina 2013;33:1659-72.  Back to cited text no. 1
Pang CE, Freund KB. Pachychoroid neovasculopathy. Retina 2015;35:1-9.  Back to cited text no. 2
Dansingani KK, Balaratnasingam C, Naysan J, Freund KB. En face imaging of pachychoroidspectrum disorders with swept-source optical coherence tomography. Retina 2016;36:499-16.  Back to cited text no. 3
Cheung CM, Lee WK, Koizumi H, Dansingani K, Lai TY, Freund KB. Pachychoroid disease. Eye (Lond) 2019;33:14-33.  Back to cited text no. 4
Spaide RF. Disease expression in non-exudative age related macular degeneration varies with choroidal thickness. Retina 2018;38:708-16.  Back to cited text no. 5
Singh SR, Chakurkar R, Goud A, Chhablani J. Low incidence of pachydrusen in central serous chorioretinopathy in an Indian cohort. Indian J Ophthalmol 2020;68:118-22.  Back to cited text no. 6
  [Full text]  
Matsumoto H, Mukai R, Morimoto M, Tokui S, Kishi S, Akiyama H. Clinical characteristics of pachydrusen in central serous chorioretinopathy. Graefes Arch ClinExp Ophthalmol 2019;257:1127-32.  Back to cited text no. 7
Baek J, Lee JH, Chung BJ, Lee K, Lee WK. Choroidal morphology under pachydrusen. Clin Exp Ophthalmol 2019;47:498-504.  Back to cited text no. 8


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded107    
    Comments [Add]    

Recommend this journal