• Users Online: 50119
  • Home
  • Print this page
  • Email this page

   Table of Contents      
PHOTO ESSAY
Year : 2020  |  Volume : 68  |  Issue : 1  |  Page : 185-186

Management of pseudophakic bullous keratopathy with ultrathin Descemet stripping automated endothelial keratoplasty and modified Yamanes' technique of scleral fixation


National Institute of Ophthalmology, 1187/30, Off Ghole Road, Near Phule Museum, Shivaji Nagar, Pune, Maharashtra, India

Date of Submission16-Feb-2019
Date of Acceptance03-Aug-2019
Date of Web Publication19-Dec-2019

Correspondence Address:
Dr. Jai Kelkar
National Institute of Ophthalmology, 1187/30, Off Ghole Road, Near Phule Museum, Shivaji Nagar, Pune - 411 005, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_321_19

Rights and Permissions
  Abstract 


Keywords: Pseudophakic bullous keratopathy, ultrathin dsek, scleral fixated IOL


How to cite this article:
Kelkar J, Kelkar A, Chougule Y. Management of pseudophakic bullous keratopathy with ultrathin Descemet stripping automated endothelial keratoplasty and modified Yamanes' technique of scleral fixation. Indian J Ophthalmol 2020;68:185-6

How to cite this URL:
Kelkar J, Kelkar A, Chougule Y. Management of pseudophakic bullous keratopathy with ultrathin Descemet stripping automated endothelial keratoplasty and modified Yamanes' technique of scleral fixation. Indian J Ophthalmol [serial online] 2020 [cited 2024 Mar 28];68:185-6. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2020/68/1/185/273235



A 66-year-old pseudophakic female was presented with visual acuity of counting fingers close to face in the right eye following blunt trauma with ball two months back. Slit lamp examination revealed bullous keratopathy (BK) with moderate subluxation of intraocular lens temporally in the right eye. Status of the capsular bag could not be assessed because of corneal haze [Figure 1]. B-scan ultrasonography showed a normal posterior segment. Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK) with removal of the subluxated lens with sutureless 27-gauge needle-assisted flanged intrascleral intraocular lens (IOL) fixation was performed [Figure 2].
Figure 1: Slit lamp examination showing BK with subluxated IOL in the right eye

Click here to view
Figure 2: UT-DSAEK with sutureless 27-gauge needle-assisted flanged intrascleral IOL fixation

Click here to view


Sutureless 27-gauge needle-assisted flanged IOL fixation

Using peribulbar anesthesia of 5-mL lignocaine hydrochloride 2.0% and 5-mL bupivacaine hydrochloride 0.5%, conjunctival entry spots were marked 180° apart with a marker at 3'o clock and 9'o clock meridians, 2 mm from the limbus. Superior conjunctiva was dissected and a 4-mm sclerocorneal tunnel was made. Corneal epithelium was removed mechanically using 15 number blade to improve visualization. Following adequate triamcinolone-assisted anterior vitrectomy and removal of the dysfunctional IOL, a three-piece IOL Sensar AR40e [Abbott Medical Optics, Santa Ana, CA] was inserted into the anterior chamber. Using the previous marking, a transconjuctival angled sclerotomy was made with a 27-gauge needle, 2 mm from the limbus, keeping it tangential with the iris plane to avoid ciliary body injury. A 25G end gripping forcep was introduced from a paracentesis to insert the tip of the leading haptic into the lumen of the 27-gauge needle. The haptics were externalized and the tip was heated with a thermal cautery to create a flange, which was subsequently pushed back through the conjunctiva and fixed intrasclerally. The same technique was repeated 180° opposite to flange and fix the trailing haptic.

UT DSAEK technique

The UT-DSAEK donor graft was prepared by double pass technique using microkeratome (Moria) as per normogram developed by Busin et al. Thickness of lenticule achieved was 100 microns.

Pilocarpine Nitrate 0.5% injection (InjCarpinol 0.5%, Sunways India Pvt., Ltd.) was injected intracamerally to achieve miosis. Host corneal marking with blunt trephine was done on epithelial side to guide Descemet membrane scoring 2 mm less than the horizontal white-to-white diameter. Descemet membrane was stripped from the host using a reverse Sinsky hook after insertion of ophthalmic viscoelastic device (OVD) (Healon; Advanced Medical Optics, Co). A small peripheral iridectomy made using automated vitrectomy cutter to avoid pupillary block by full chamber air. The OVD was completely removed before insertion of donor lenticule by irrigation and aspiration. The graft was then delivered into the anterior chamber via the needle push technique through sclerocorneal wound. The wound was closed with a 10-0 nylon suture. The anterior chamber was filled with air injected via a 30-gauge cannula and final graft position was ensured by stroking the cornea with an iris repositor. Donor lenticule stability was confirmed after 10 min. The IOP was digitally checked and the eye was then patched. Patient remained supine for 1 h.

The anterior segment optical coherence tomography (ASOCT) done post operatively, showed a well apposed endothelial disc and positioning of the haptics flanges within the sclera [Figure 3]. Uncorrected visual acuity improved from 1.48 logMAR units at baseline to 0.6 logMAR at 6 weeks, which was maintained at six months. BCVA at last follow-up of 11 months was 0.5 logMAR units. The endothelial cell loss was 20%.
Figure 3: (a) Anterior segment optical coherence tomography (ASOCT) done post operatively, showed a well-apposed endothelial disc. (b) The ASOCT done shows positioning of the haptics flanges within the sclera post operatively

Click here to view



  Discussion Top


In majority of the cases of BK, the causative factor is either aphakia or dysfunctional IOL, which may require consecutive removal and replacement along with posterior lamellar keratoplasty.

UT-DSAEK is easier to perform even in eyes with complicated anatomy or poor anterior chamber visualization.

The ideal IOL option in this scenario is a transscleral fixated IOL or iris retrofixated lens, the rationale being to maintain maximum distance between the IOL and the donor endothelium thereby minimizing damage to anterior chamber angle structures. Yamanes' technique offers ease of performance, shorter learning curve, good lens centration, and transconjunctival approach.

We modified Yamane's technique of exteriorizing both haptics simultaneously and exteriorized and fixed the leading haptic entirely before manipulating the lagging haptic, thus obviating risk of peripheral retinal injury and haptic slippage.[1],[2] The SFIOL was very stable during all maneuvers of UTDSAEK, even during the air tamponade. There were no intraoperative and postoperative complications noted. Our results are comparable to the previously done studies on combined technique of DSAEK with SFIOL.[3],[4],[5] and it is a very unique and effective in management of aphakic and pseudophakic BK.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Ramakrishnan S, Ganne P, Nagesha CK, Baskaran P. Descemet-stripping endothelial keratoplasty and flange technique of scleral fixation of intraocular lens: Making it easier and safer. J Cataract Refractive Surg 2017;43:1238-9.  Back to cited text no. 1
    
2.
Kelkar AS, Fogla R, Kelkar J, Kothari AA, Mehta H, Amoaku W. Sutureless 27-gauge needle-assisstedtransconjuctival intrascleral intraocular lens fixation: Initial experience. Indian J Ophthalmol 2017;65:1450-3.  Back to cited text no. 2
[PUBMED]  [Full text]  
3.
Wylęgała E, Tarnawska D. Management of pseudophakic bullous keratopathy by combined Descemet-stripping endothelial keratoplasty and intraocular lens exchange. J Cataract Refract Surg 2008;34:1708-14.  Back to cited text no. 3
    
4.
Sinha R, Shekhar H, Sharma N, Tandon R, Titiyal JS, Vajpayee RB. Intrascleral fibrin glue intraocular lens fixation combined with Descemet- stripping automated endothelial keratoplasty or penetrating keratoplasty. J Cataract Refract Surg 2012;38:1240-5.  Back to cited text no. 4
    
5.
Cervantes LJ. Combined double-needle flanged-haptic intrascleral fixation of an intraocular lens and Descemet-stripping endothelial keratoplasty. J Cataract Refract Surg 2017;43:593-6.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]


This article has been cited by
1 Application of biomaterials and nanotechnology in corneal tissue engineering
Mohammad Soleimani, Zohreh Ebrahimi, Kosar Sadat Ebrahimi, Negin Farhadian, Mohsen Shahlaei, Kasra Cheraqpour, Hamed Ghasemi, Sajad Moradi, Arthur Y. Chang, Sina Sharifi, Seyed Mahbod Baharnoori, Ali R. Djalilian
Journal of International Medical Research. 2023; 51(7)
[Pubmed] | [DOI]
2 Concomitant sutureless scleral fixation of intraocular lens with keratoplasty
Rinky Agarwal, Chetan Shakarwal, Namrata Sharma, Jeewan S Titiyal
Indian Journal of Ophthalmology. 2023; 71(5): 1718
[Pubmed] | [DOI]
3 Outcomes of Secondary Intraocular Lens Implantation and Descemet Stripping Endothelial Keratoplasty—Comparing Staged Versus Combined Surgical Approach
Courtney F. Goodman, Rhiya Mittal, Abdelhalim Awidi, Elizabeth A. Vanner, Elaine Han, Yassine J. Daoud, Ellen H. Koo
Cornea. 2022; Publish Ah
[Pubmed] | [DOI]
4 Descemet-stripping automated endothelial keratoplasty with intrascleral haptic–fixated intraocular lens in a sequential vs simultaneous approach
Rajesh Sinha, Hannah Shiny, Sridevi Nair, Namrata Sharma, Tushar Agarwal, Jeewan Singh Titiyal
Journal of Cataract and Refractive Surgery. 2021; 47(6): 767
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
Abstract
Discussion
References
Article Figures

 Article Access Statistics
    Viewed1609    
    Printed46    
    Emailed0    
    PDF Downloaded178    
    Comments [Add]    
    Cited by others 4    

Recommend this journal