• Users Online: 739
  • Home
  • Print this page
  • Email this page

   Table of Contents      
Year : 2020  |  Volume : 68  |  Issue : 6  |  Page : 1163-1165

Importance of neuroimaging in normal tension glaucoma

M and J Western Regional Institute of Ophthalmology, Civil Hospital Road, Ahmedabad, Gujarat, India

Date of Submission29-Aug-2019
Date of Acceptance10-Dec-2019
Date of Web Publication25-May-2020

Correspondence Address:
Dr. Jaideep Sharma
188 A Lane No. 7, Govind Path, Katewa Nagar, Jaipur - 302 019, Rajasthan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijo.IJO_1577_19

Rights and Permissions

Keywords: Magnetic resonance imaging, normal tension glaucoma, primary empty sella

How to cite this article:
Sharma J, Jain A, Bhagat PR. Importance of neuroimaging in normal tension glaucoma. Indian J Ophthalmol 2020;68:1163-5

How to cite this URL:
Sharma J, Jain A, Bhagat PR. Importance of neuroimaging in normal tension glaucoma. Indian J Ophthalmol [serial online] 2020 [cited 2023 Oct 1];68:1163-5. Available from: https://journals.lww.com/ijo/pages/default.aspx/text.asp?2020/68/6/1163/284805

Primary empty sella syndrome (PESS) is caused by an increase in the cerebrospinal fluid (CSF) pressure or a defect in the diaphragma sellae, where the pituitary gland is absent or present as a thin membrane.[1] Optic nerve examination and visual field analysis show glaucomatous changes with normal intraocular pressures (IOPs).

A 51-year-old male weighing 65 kg presented with gradual progressive painless diminution of vision in both eyes for 1 year with no significant medical or other histories. Best-corrected visual acuity (BCVA) oculus dexter (OD) was counting fingers near face and oculus sinister (OS) was 6/18. Intraocular pressures (IOPs) were normal. A relative afferent pupillary defect in the right eye (RE) was found. Color vision was defective. Gonioscopy revealed open angles in both eyes. Pachymetry was in the normal range. Fundus examination OD revealed a 0.7-cup disc ratio and in OS 0.8-cup disc ratio, with both eyes showing bayonetting, baring of circumlinear vessels, and nasalization of blood vessels, with rim pallor more than cupping suggesting neurophthalmic cause [Figure 1].
Figure 1: Fundus photographs showing advanced optic disc changes with rim pallor in RE and LE

Click here to view

Two hourly diurnal fluctuations ranged normal. Visual field examination showed severe generalized depression, tubular field and absence of split fixation in the left eye (LE) [Figure 2].
Figure 2: LE visual field on octopus perimetry G program and M program

Click here to view

All systemic investigations were within normal limits.

Magnetic resonance imaging revealed an empty sella [Figure 3] and venography was non-significant.
Figure 3: MRI of the brain and both orbits

Click here to view

Normal tension glaucoma (NTG) is a diagnosis made after excluding causes of burnout glaucoma and previous episodes of acute hemodynamic disturbances.[2] In PESS, nerve fibers in optic chiasm are perfused from the posterior communicating arteries, which pass round the infundibulum above the pituitary gland. If any mechanical changes occur near the pituitary or sella turcica, the arachnoid may be drawn inferiorly simultaneously pulling the optic chiasm and perfusion vessels downward with resultant optic nerve ischemic changes.[3] We need to remember this association between empty sella, NTG and resultant visual loss.[4] Hence, it becomes necessary to include neuroimaging as an added diagnostic tool in our armamentarium for NTG to avoid diagnostic delay and prevent visual disability.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Busch W. [Morphology of sella turcica and its relation to the pituitary gland]. Virchows Arch Pathol Anat Physiol Klin Med 1951;320:437-58.  Back to cited text no. 1
Drance SM, Morgan RW, Sweeney VP. Shock-induced optic neuropathy: A cause of nonprogressive glaucoma. N Engl J Med 1973;288:392-5.  Back to cited text no. 2
Bergland RM, Ray BS, Torack RM. Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J Neurosurg 1968;28:93-9.  Back to cited text no. 3
Doro D, de Natale MT, Cimatti P. Puzzling visual field loss in patients with primary empty sella. Perimetry Update 1998;529-32.  Back to cited text no. 4


  [Figure 1], [Figure 2], [Figure 3]

This article has been cited by
1 Empty-Sella-Syndrom und/oder Normaldruckglaukom?
Iva R. Bartmann, Kai Kallenberg, Maged Alnawaiseh, Natasa Mihailovic
Der Ophthalmologe. 2022;
[Pubmed] | [DOI]
2 Commentary: Neuro-ophthalmological conditions mimicking glaucoma A diagnostic challenge
Srinivasan Kavitha
Indian Journal of Ophthalmology. 2020; 68(6): 1165
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Article Figures

 Article Access Statistics
    PDF Downloaded144    
    Comments [Add]    
    Cited by others 2    

Recommend this journal