• Users Online: 4282
  • Home
  • Print this page
  • Email this page

   Table of Contents      
LETTER TO THE EDITOR
Year : 2021  |  Volume : 69  |  Issue : 4  |  Page : 1002-1004

COVID-19 and orbital mucormycosis


1 Department of Ophthalmology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India
2 Department of Microbiology, Jawaharlal Institute of Post Graduate Medical Education and Research, Karaikal, India

Date of Web Publication16-Mar-2021

Correspondence Address:
Dr. Amit Kumar Deb
Department of Ophthalmology, Jawaharlal Institute of Post Graduate Medical Education and Research, Gorimedu, Puducherry - 605 006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijo.IJO_3763_20

Rights and Permissions

How to cite this article:
Sarkar S, Gokhale T, Choudhury SS, Deb AK. COVID-19 and orbital mucormycosis. Indian J Ophthalmol 2021;69:1002-4

How to cite this URL:
Sarkar S, Gokhale T, Choudhury SS, Deb AK. COVID-19 and orbital mucormycosis. Indian J Ophthalmol [serial online] 2021 [cited 2022 Oct 1];69:1002-4. Available from: https://www.ijo.in/text.asp?2021/69/4/1002/311262



Dear Editor,

The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first reported in Wuhan, Hubei province in China, quickly spread to other parts of the world forming a global pandemic.[1] The disease pattern of COVID-19 can range from mild to life-threatening pneumonia with associated bacterial and fungal coinfections.[2] Due to the associated comorbidities (e.g., diabetes mellitus, chronic obstructive pulmonary disease) and immunocompromised conditions (e.g. corticosteroid therapy, ventilation, intensive care unit stay), these patients are prone to develop severe opportunistic infections. There are reports of the development of severe opportunistic infections such as oropharyngeal candidiasis, pneumocystis jiroveci pneumonia, pulmonary aspergillosis, bloodstream candida infections, etc., in patients affected with COVID-19 disease.[3],[4] There are also few isolated case reports of rhino-orbital mucormycosis in COVID-19 disease.[2],[5] Sen et al. recently reported a series of six cases of COVID-19 disease with rhino-orbital mucormycosis. One patient in this series had concurrent COVID-19 and mucormycosis at admission, while five other patients developed mucormycosis during treatment with systemic steroids for COVID-19.[6] We, hereby, report a cluster of 10 cases of clinically diagnosed orbital mucormycosis with concurrent COVID-19 illness at our institute over the last 2 months (October and November 2020). They presented to us with clinical features of orbital mucormycosis and COVID-19 was diagnosed on routine screening. Demographic and clinical profiles of the patients are provided in [Table 1]. Microbiological and radiological diagnosis along with treatment received and final outcome are provided in [Table 2]. Potassium hydroxide (KOH) wet mount and fungal culture/sensitivity were done from biopsy obtained during debridement or from nasal swab obtained during diagnostic nasal endoscopy. Microbiological diagnosis of mucormycosis was proven in six patients. Reverse transcriptase-polymerase chain reaction (RT-PCR) tests for COVID-19 were positive in all the patients. All patients in our series were known diabetics. Diabetic ketoacidosis (DKA) was evident in four patients during admission while five more patients developed DKA after the initiation of corticosteroid therapy for COVID-19 disease. All patients in our series had received intravenous dexamethasone for COVID-19 disease as per The National Institute of Health recommendations[7] and Liposomal Amphotericin B for mucormycosis. Besides, four patients received an injection of Remdesivir, and nine patients required ventilatory support during their hospital stay. The use of steroids, monoclonal antibodies, and broad-spectrum antibiotics for the management of COVID-19 illness can increase the chances of new-onset fungal infection or exacerbate a preexisting one.[2] All patients in our series had received intravenous dexamethasone for COVID-19 disease and Liposomal Amphotericin B for mucormycosis. Four patients in our series expired within 1 month of the diagnosis, five patients had satisfactory systemic outcomes, but with irreversible vision loss, while only one patient had both ocular and systemic favorable outcomes.
Table 1: Demographic and clinical profiles of the patients

Click here to view
Table 2: Radiological and microbiological diagnosis, treatment, and final outcome of the patients

Click here to view


COVID-19 disease has a propensity to cause extensive pulmonary disease and subsequent alveolo-interstitial pathology. This by itself may predispose to invasive fungal infections of the airways including the sinuses and the lungs.[2],[8] Furthermore, there is an alteration of the innate immunity due to COVID-19-associated immune dysregulation characterized by decreased T cells, including CD4 and CD8 cells.[2],[6] All physicians including ophthalmologists should, therefore, be mindful of the probability of development of fungal infections such as mucormycosis in patients with COVID-19 illness, especially in those with comorbidities and on immunosuppressive agents in the coming future.[6]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Farnoosh G, Alishiri G, Hosseini Zijoud SR, Dorostkar R, Jalali Farahani A. Understanding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19) based on available evidence-A narrative review. J Mil Med 2020;22:1-11.  Back to cited text no. 1
    
2.
Mehta S, Pandey A. Rhino-orbital mucormycosis associated with COVID-19. Cureus 2020;12:e10726.  Back to cited text no. 2
    
3.
Salehi M, Ahmadikia K, Badali H, Khodavaisy S. Opportunistic fungal infections in the epidemic area of COVID-19: A clinical and diagnostic perspective from Iran. Mycopathologia 2020;185:607-11.  Back to cited text no. 3
    
4.
Chowdhary A, Tarai B, Singh A, Sharma A. Multidrug-resistant Candida auris infections in critically Ill coronavirus disease patients, India, April–July 2020. Emerg Infect Dis 2020;26:2694-6.  Back to cited text no. 4
    
5.
Mekonnen ZK, Ashraf DC, Jankowski T, Grob SR, Vagefi MR, Kersten RC, et al. Acute invasive rhino-orbital mucormycosis in a patient with COVID-19-associated acute respiratory distress syndrome. Ophthalmic Plast Reconstr Surg 2020. doi: 10.1097/IOP. 0000000000001889.  Back to cited text no. 5
    
6.
Sen M, Lahane S, Lahane TP, Parekh R, Honavar SG. Mucor in a viral land: A tale of two pathogens. Indian J Ophthalmol 2021;69:244-52.  Back to cited text no. 6
[PUBMED]  [Full text]  
7.
COVID-19 Treatment Guidelines Panel. Coronavirus disease 2019 (COVID-19) treatment guidelines. National Institutes of Health. 2020. [Last accessed on 2020 Dec 23].  Back to cited text no. 7
    
8.
Gangneux JP, Bougnoux ME, Dannaoui E, Cornet M, Zahar JR. Invasive fungal diseases during COVID-19: We should be prepared. J Mycol Med 2020;30:100971. doi: 10.1016/j.mycmed.2020.100971.  Back to cited text no. 8
    



 
 
    Tables

  [Table 1], [Table 2]


This article has been cited by
1 Mucormycosis infection in patients with COVID -19: A systematic review
SeyedAhmad SeyedAlinaghi, Amirali Karimi, Alireza Barzegary, Zahra Pashaei, Amir Masoud Afsahi, Sanam Alilou, Nazanin Janfaza, Alireza Shojaei, Fatemeh Afroughi, Parsa Mohammadi, Yasna Soleimani, Newsha Nazarian, Ava Amiri, Marcarious M. Tantuoyir, Shahram Oliaei, Esmaeil Mehraeen, Omid Dadras
Health Science Reports. 2022; 5(2)
[Pubmed] | [DOI]
2 Mucormycosis in COVID-19 pandemic: study at tertiary hospital in India
Reshma P. Chavan, Shivraj M. Ingole, Hamna Abdul Nazir, Wilson V. Desai, Gajanan S. Kanchewad
European Archives of Oto-Rhino-Laryngology. 2022;
[Pubmed] | [DOI]
3 The impact of mucormycosis (black fungus) on SARS-CoV-2-infected patients: at a glance
Md. Rezaul Islam, Md. Mominur Rahman, Md. Tanjimul Ahasan, Nadia Sarkar, Shopnil Akash, Mahfuzul Islam, Fahadul Islam, Most. Nazmin Aktar, Mohd Saeed, Md. Harun-Or-Rashid, Md. Kawsar Hosain, Md. Saidur Rahaman, Sadia Afroz, Shabana Bibi, Md. Habibur Rahman, Sherouk Hussein Sweilam
Environmental Science and Pollution Research. 2022;
[Pubmed] | [DOI]
4 Mucormycosis: risk factors, diagnosis, treatments, and challenges during COVID-19 pandemic
Ayushi Sharma, Anjana Goel
Folia Microbiologica. 2022;
[Pubmed] | [DOI]
5 Mortality-Related Risk Factors for Coronavirus Disease (COVID-19)-Associated Mucormycosis: a systematic review and meta-analysis
Vahid Reza Ostovan, Reza Tabrizi, Hanieh Bazrafshan, Zahra Bahrami, Hajar Khazraei, Samaneh Khazraei, Afshin Borhani-Haghighi, Mohsen Moghadami, Matthew Grant
Current Fungal Infection Reports. 2022;
[Pubmed] | [DOI]
6 Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India
Deganta Ghosh, Sagardeep Dey, Himanko Chakraborty, Sneha Mukherjee, Ankita Halder, Akash Sarkar, Pallab Chakraborty, Rajdeep Ghosh, Joy Sarkar
Clinical Epidemiology and Global Health. 2022; 15: 101013
[Pubmed] | [DOI]
7 The role of SARS-CoV-2 immunosuppression and the therapy used to manage COVID-19 disease in the emergence of opportunistic fungal infections: A review
Nahid Akhtar, Atif Khurshid Wani, Surya Kant Tripathi, Ajit Prakash, M. Amin-ul Mannan
Current Research in Biotechnology. 2022;
[Pubmed] | [DOI]
8 An overview of COVID-19 related to fungal infections: what do we know after the first year of pandemic?
R. G. Vitale, J. Afeltra, S. Seyedmousavi, S. L. Giudicessi, S. M. Romero
Brazilian Journal of Microbiology. 2022;
[Pubmed] | [DOI]
9 Mucormycosis and COVID-19 pandemic: Clinical and diagnostic approach
Asim Azhar, Wajihul Hasan Khan, Parvez Anwar Khan, Khaled Al-hosaini, Mohammad Owais, Aijaz Ahmad
Journal of Infection and Public Health. 2022;
[Pubmed] | [DOI]
10 COVID-19 associated mucormycosis – An emerging threat
Chien-Ming Chao, Chih-Cheng Lai, Wen-Liang Yu
Journal of Microbiology, Immunology and Infection. 2022;
[Pubmed] | [DOI]
11 COVID-19 and Fungal Infections: A Double Debacle
Sara Mina, Hajar Yaakoub, Cédric Annweiler, Vincent Dubée, Nicolas Papon
Microbes and Infection. 2022; : 105039
[Pubmed] | [DOI]
12 Experience on rhino-orbital mucormycosis from a tertiary care hospital in the first wave of COVID-19: An Indian perspective
Gunjan Saluja, Anju Bhari, Neelam Pushker, Sahil Agrawal, Rachna Meel, Alok Thakar, Immaculata Xess, Ankur Khandelwal, Anubhav Narwal, Mandeep S. Bajaj
Medical Journal Armed Forces India. 2022;
[Pubmed] | [DOI]
13 Mucormycosis (black fungus) ensuing COVID-19 and comorbidity meets - Magnifying global pandemic grieve and catastrophe begins
Karthika Pushparaj, Haripriya Kuchi Bhotla, Vijaya Anand Arumugam, Manikantan Pappusamy, Murugesh Easwaran, Wen-Chao Liu, Utthapon Issara, Kannan R.R. Rengasamy, Arun Meyyazhagan, Balamuralikrishnan Balasubramanian
Science of The Total Environment. 2022; 805: 150355
[Pubmed] | [DOI]
14 Coronavirus Disease 2019 (COVID-19)–Associated Rhino-Orbito-Cerebral Mucormycosis: A Multi-Institutional Retrospective Study of Imaging Patterns
Sharath Kumar GG, Saikant Deepalam, Ata Siddiqui, Chaitra P. Adiga, Savith Kumar, Shivakumar Swamy Shivalingappa, Ullas V. Acharya, Lakshmikanth N. Goolahally, Saksham Sharma, Dhilip Andrew, Pradeep Hosmani, Satish Nair, Gaurav Medikeri, Ravi Mohan Rao, Jagadish B. Agadi, Sujit Kumar, Gurucharan Adoor, Suryanarayana Sharma, Raghuraj Hegde, Jitender Saini, Karthik Kulanthaivelu
World Neurosurgery. 2022;
[Pubmed] | [DOI]
15 The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries
Martin Hoenigl, Danila Seidel, Agostinho Carvalho, Shivaprakash M Rudramurthy, Amir Arastehfar, Jean-Pierre Gangneux, Nosheen Nasir, Alexandro Bonifaz, Javier Araiza, Nikolai Klimko, Alexandra Serris, Katrien Lagrou, Jacques F Meis, Oliver A Cornely, John R Perfect, P Lewis White, Arunaloke Chakrabarti
The Lancet Microbe. 2022;
[Pubmed] | [DOI]
16 An insight into SARS-CoV-2 structure, pathogenesis, target hunting for drug development and vaccine initiatives
Arijit Ghosh, Paritosh K. Kar, Anupam Gautam, Rahul Gupta, Rajveer Singh, Rudra Chakravarti, Velayutham Ravichandiran, Shubhra Ghosh Dastidar, Dipanjan Ghosh, Syamal Roy
RSC Medicinal Chemistry. 2022;
[Pubmed] | [DOI]
17 COVID-19 Associated Mucormycosis with Newly Diagnosed Diabetes Mellitus in Young Males – A Tertiary Care Experience
Sahil Kapoor, Poonam Kumar Saidha, Ayushi Gupta, Urvi Saini, Sneha Satya
International Archives of Otorhinolaryngology. 2022; 26(03): e470
[Pubmed] | [DOI]
18 Onset of Mucormycosis in Patients with COVID-19: A Systematic Review on Patients' Characteristics
Shohreh Ghasemi, Mahmood Dashti, Amir Fahimipour, Ghazaleh Daryakenari, Fatemeh Mirzaei, Fatemeh Akbari, Zohaib Khurshid
European Journal of Dentistry. 2022;
[Pubmed] | [DOI]
19 A fungal epidemic amidst a viral pandemic: Risk factors for development of COVID-19 associated rhino-orbital-cerebral mucormycosis in India
Varshitha Hemanth Vasanthapuram, Roshmi Gupta, Namrata Adulkar, Akshay Gopinathan Nair, Renuka A Bradoo, Raghuraj Hegde, Usha Singh, Sameeksha Tadepalli, Bipasha Mukherjee, Saurabh Kamal, Md Shahid Alam, Raksha Rao, Sushma Ananthakrishna, Varsha Backiavathy, Ajay Krishna Murthy, Lynn D’Cunha, Gagan Dudeja, Annie Joji, Anjali Kiran, Kirti Koka, Moupia Goswami Mukhopadhyay, Sonam Poonam Nisar, Priyanka R. Rao, Chhaya A. Shinde
Orbit. 2022; : 1
[Pubmed] | [DOI]
20 MRI as a road map for surgical intervention of acute invasive fungal sinusitis in Covid-19 era
Ahmed Hassan Sweed, Mohamed Mobashir, Ismail Elnashar, Ahmed Anany, Mohammed Elsayed Elmaghawry, Enas Moustafa Ibrahim, Mohamed Eesa
Clinical Otolaryngology. 2022;
[Pubmed] | [DOI]
21 Sensitivity of liquid-based cytology in the diagnosis of mucormycosis in COVID -19 treated patients
Rabish Kumar, Meeta Singh, Tanu Sagar,   Bharanidharan, Nita Khurana, Vikas Kumar, Ravi Meher, Vikas Malhotra, Ruchi Goel, Sonal Saxena, Jyoti Kumar
Cytopathology. 2022;
[Pubmed] | [DOI]
22 COVID-19-associated acute invasive fungal sinusitis: Clinical and imaging findings
Ali H. Elmokadem, Dalia Bayoumi, Manar Mansour, Mahitab Ghonim, Eman A. Saad, Doaa Khedr
Journal of Neuroimaging. 2022;
[Pubmed] | [DOI]
23 Epidemiology, clinical presentation and management of COVID-19 associated mucormycosis: A single centre experience from Pune, Western India
Ameet Dravid, Reema Kashiva, Zafer Khan, Balasaheb Bande, Danish Memon, Aparna Kodre, Milind Mane, Vishal Pawar, Dattatraya Patil, Suraj Kalyani, Prathamesh Raut, Madhura Bapte, Charlotte Saldanha, Dinesh Chandak, Teerthagouda Patil, Sateesh Reddy, Krushnadas Bhayani, Laxmi Suresh, Vishnu Dillibabu, Shipra Srivastava, Shubham Khandelwal, Sailee More, Atif Shakeel, Mohit Pawar, Pranava Nande, Amol Harshe, Sagar Kadam, Sudhir Hallikar, Nudrat Kamal, Danish Andrabi, Sachin Bodhale, Akshay Raut, Sangeeta Chandrashekhar, Chandrashekhar Raman, Uma Mahajan, Gaurav Joshi, Dilip Mane
Mycoses. 2022;
[Pubmed] | [DOI]
24 The Pathogenetic Dilemma of Post-COVID-19 Mucormycosis in India
Sankha Shubhra Chakrabarti, Upinder Kaur, Sushil Kumar Aggarwal, Ahalya Kanakan, Adesh Saini, Bimal Kumar Agrawal, Kunlin Jin, Sasanka Chakrabarti
Aging and disease. 2022; 13(1): 24
[Pubmed] | [DOI]
25 Diagnosis of invasive Mucormycosis on Histopathological examination at a tertiary referral hospital
Pavani Marapaka, Laxmi Pravalika
IP Archives of Cytology and Histopathology Research. 2022; 7(2): 85
[Pubmed] | [DOI]
26 Perioperative management of patients with post Covid rhino-orbito-cerebral mucormycosis: Prospective observational study
Bhoomika Kalarthi, Devyani Desai, Neha Shah, Neha Cheraya, Sagar Bavisetti, Parvathy D, Abhishek Zala, Kanchan Choube, Gaurav Cheraya
Indian Journal of Clinical Anaesthesia. 2022; 9(2): 214
[Pubmed] | [DOI]
27 An observational study of treatment and outcomes of patients admitted in a dedicated Covid hospital in central India during second wave of Covid -19 pandemic
Kavita M. Jaiswal, Sujata Dudhgaonkar, Ramesh Sugandh, Kalpana V Jaiswal, Latesh Raghute
IP International Journal of Comprehensive and Advanced Pharmacology. 2022; 7(3): 151
[Pubmed] | [DOI]
28 Rhinoorbital mucormycosis in COVID-19 pandemic: presentation and course of disease: An observational study
Maya Sharma, Seema Rajvanshi, Sunita Khurana, Rajkumar Arora
Indian Journal of Clinical and Experimental Ophthalmology. 2022; 7(4): 624
[Pubmed] | [DOI]
29 Posterior segment findings in post-Covid mucormycosis: A cross-sectional study
Zainu Shams, C Shwetha Kumari, Malvika S B Mutt, Bharathi N, Madhura M Khanapur
IP International Journal of Ocular Oncology and Oculoplasty. 2022; 8(2): 136
[Pubmed] | [DOI]
30 Mucormycosis in patients with COVID-19 in Russia: the results of a prospective multi-center study
S. N. Khostelidi, V. A. Zaytsev, S. A. Vartanyan, N. A. Nikitin, G. N. Evtukh, M. N. Gilalov, G. V. Portnov, A. A. Zubareva, I. B. Baranova, T. S. Bogomolova, Yu. L. Avdeenko, O. V. Shadrivova, E. A. Desyatik, E. V. Shagdileeva, Yu. V. Borzova, Yu. A. Krivolapov, N. V. Vasilyeva, N. N. Klimko
Journal Infectology. 2022; 14(2): 116
[Pubmed] | [DOI]
31 Update on overview of ocular manifestations of COVID-19
Mitra Akbari, Maryam Dourandeesh
Frontiers in Medicine. 2022; 9
[Pubmed] | [DOI]
32 Fungal Infections Other Than Invasive Aspergillosis in COVID-19 Patients
Kerri Basile, Catriona Halliday, Jen Kok, Sharon C-A. Chen
Journal of Fungi. 2022; 8(1): 58
[Pubmed] | [DOI]
33 Diagnostic Performance and Clinical Utility of Conventional PCR Assay in Early Diagnosis of COVID-19 Associated Rhino-Orbito-Cerebral Mucormycosis
Samir Mohapatra, Manas Ranjan Barik, Suryasnata Rath, Savitri Sharma, Archisman Mohapatra, Sharmistha Behera, Souvagini Acharya, Dipti Ranjan Pattjoshi, Rajesh Kumar Padhi, Himansu Sekhar Behera
Journal of Fungi. 2022; 8(8): 844
[Pubmed] | [DOI]
34 SARS-CoV-2 in Kidney Transplant Recipients: A Systematic Review
Naveen Kumar, Rashmi Rana, Devinder Singh Rana, Anurag Gupta, Mohinder Pal Sachdeva
Transplantology. 2022; 3(1): 33
[Pubmed] | [DOI]
35 COVID-19-Associated Mucormycosis: A Matter of Concern Amid the SARS-CoV-2 Pandemic
Pankaj Chandley, Priyanka Subba, Soma Rohatgi
Vaccines. 2022; 10(8): 1266
[Pubmed] | [DOI]
36 IMAGING OF RHINO-ORBITO-CEREBRAL MUCORMYCOSIS A PROSPECTIVE OBSERVATIONAL STUDY IN THE SETTING OF COVID 19 PANDEMIC IN A TERTIARYCARE CENTRE IN AP, INDIA
P. Sathishkumar, K. Sindhura, Bomidi Sudha Rani, P. Bujjibabu
INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. 2022; : 36
[Pubmed] | [DOI]
37 RELATIONSHIP OF HYPOALBMINEMIA WITH OUTCOME OF RHINO-ORBITO-CEREBRAL MUCORMYCOSIS (ROCM), A TERTIARY CARE CENTER BASED STUDY.
Shyamash Mandal, Souvik Das, Abhisek Mallik, Syamal Kundu
PARIPEX INDIAN JOURNAL OF RESEARCH. 2022; : 29
[Pubmed] | [DOI]
38 Study of Molds in Post COVID -19 Patients: An experience from Tertiary Care Centre
Neeta Gade
Journal of Infectious Diseases & Microbiology. 2022;
[Pubmed] | [DOI]
39 Mucormycosis in patients with COVID-19: A descriptive study at a tertiary care hospital in North Maharashtra
GaneshShrihari Lokhande, YogitaGopal Bavaskar, VilasRaghunath Malkar, Jaiprakash Ramanand, JitendraBhaskar Surwade, DanielArun Saji, Sandeep Suryawanshi
MGM Journal of Medical Sciences. 2022; 9(1): 72
[Pubmed] | [DOI]
40 Mucormycosis in Post-COVID Patients: A Review
K Manimekalai, JV Sabarianandh, Packia Sakaya Mercy, L Bernaitis, L Benita Mary
SBV Journal of Basic, Clinical and Applied Health Science. 2022; 5(2): 34
[Pubmed] | [DOI]
41 Study of Profile of Mucormycosis During the Second Wave of COVID-19 in a Tertiary Care Hospital
Sangita Kamath, Manish Kumar, Nilanjan Sarkar, Tauheed Ahmed, Ashok Sunder
Cureus. 2022;
[Pubmed] | [DOI]
42 Clinicopathological Study of Mucormycosis in COVID-19 Patients: Experience From a Tertiary Care Center in South India
Sangeetha Kandasamy, Srinivas Muthuraju, Arumugam Vasugi, Megala Chandrasekar, Roopmala Murugan, Poovizhi Inbasekaran, Prabu R
Cureus. 2022;
[Pubmed] | [DOI]
43 Outcomes of Transcutaneous Retrobulbar Amphotericin B in Rhino-Orbital-Cerebral Mucormycosis Among Patients Recovering From COVID-19: A Preliminary Experience
Shivani Sinha, Vidya B Kumar, Abhay Kumar, Vivek Singh, Abhishek Anand, Rakhi Kusumesh, Sarita Mishra, Pragati Raj, Bibhuti P Sinha
Cureus. 2022;
[Pubmed] | [DOI]
44 Clinical Profile of Patients Admitted With Mucormycosis During the COVID-19 Pandemic in Medicine Emergency of a Tertiary Care Hospital in North India
Neeraj Singla, Nalin Sharma, Navneet Sharma, Ashish Behera, Mandip Bhatia
Cureus. 2022;
[Pubmed] | [DOI]
45 Rhino-orbital-cerebral mucormycosis as a complication of coronavirus disease 2019
Raid M Al-Ani
World Journal of Virology. 2022; 11(5): 293
[Pubmed] | [DOI]
46 Coronavirus Disease-Associated Mucormycosis from a Tertiary Care Hospital in India: A Case Series
Yudhyavir Singh, Venkata Ganesh, Shailendra Kumar, Nishant Patel, Richa Aggarwala, Kapil Dev Soni, Anjan Trikha
Cureus. 2021;
[Pubmed] | [DOI]
47 A Retrospective Analysis of Risk Factors of COVID-19 Associated Mucormycosis and Mortality Predictors: A Single-Center Study
Kapil Zirpe, Prajakta Pote, Abhijit Deshmukh, Sushma K Gurav, Anand M Tiwari, Prasad Suryawanshi
Cureus. 2021;
[Pubmed] | [DOI]
48 Emerging cases of mucormycosis under COVID -19 pandemic in India: Misuse of antibiotics
Gaurav Gupta, Roshan S., Yogendra Singh, Lakshmi Thangavelu, Sachin Kumar Singh, Harish Dureja, Dinesh Kumar Chellappan, Kamal Dua
Drug Development Research. 2021; 82(7): 880
[Pubmed] | [DOI]
49 Optic neuritis in post-Covid rhino-orbito-cerebral mucormycosis (ROCM): A rare presentation
Parul Singh, Perwez Khan, Anshika Gupta, Namrata Patel, Tejasvini Chandra, Dinesh Kumar Yadav
International Journal of Case Reports and Images. 2021; 12: 1
[Pubmed] | [DOI]
50 Mucormycosis in COVID Diabetic Patients: A Horrifying Triad!
Amit Kumar, Bhavna Gupta, Anish Gupta, Parshika Panwar, Shiv C Navriya
Indian Journal of Critical Care Medicine. 2021; 25(11): 1314
[Pubmed] | [DOI]
51 Mucormycosis following COVID19: clinical case and literature review
Sofya N. Khostelidi, V.A. Zaytsev, E.V. Pelikh, E.V. Yashina, O.N. Rodionova, T.S. Bogomolova, Yu.L. Avdeenko, Nikolay N. Klimko
Clinical Microbiology and Antimicrobial Chemotherapy. 2021; 23(3): 255
[Pubmed] | [DOI]
52 Nanomaterial-Based Antifungal Therapies to Combat Fungal Diseases Aspergillosis, Coccidioidomycosis, Mucormycosis, and Candidiasis
Angel León-Buitimea, Javier A. Garza-Cervantes, Diana Y. Gallegos-Alvarado, Macario Osorio-Concepción, José Ruben Morones-Ramírez
Pathogens. 2021; 10(10): 1303
[Pubmed] | [DOI]
53 Synthesis and Study of Antifungal Properties of New Cationic Beta-Glucan Derivatives
Kamil Kaminski, Magdalena Skora, Pawel Krzysciak, Sylwia Staczek, Agnieszka Zdybicka-Barabas, Malgorzata Cytrynska
Pharmaceuticals. 2021; 14(9): 838
[Pubmed] | [DOI]
54 Newer Horizon of Mesenchymal Stem Cell–Based Therapy in the Management of SARS-CoV-2–Associated Mucormycosis: A Safe Hope for Future Medicine
Alok Raghav, Syed Ghazanfar Ali, Goo-Bo Jeong, Kirti Amresh Gautam, Shahid Banday, Qazi Noorul Mateen, Prashant Tripathi, Richa Giri, Saurabh Agarwal, Manish Singh, Haris M. Khan
Frontiers in Microbiology. 2021; 12
[Pubmed] | [DOI]
55 Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention
Syed Mohammed Basheeruddin Asdaq, Arya Rajan, Aswin Damodaran, Shivali R. Kamath, Krishnanjana S. Nair, Subin Mary Zachariah, Ram Kumar Sahu, Santosh Fattepur, Nagaraja Sreeharsha, Anroop Nair, Shery Jacob, Hussain A. Albahrani, Eman H. Alkhaldi, Yahya Mohzari, Ahmed A. Alrashed, Mohd. Imran
Antibiotics. 2021; 10(11): 1308
[Pubmed] | [DOI]
56 COVID-19 Associated Mucormycosis: A Systematic Review from Diagnostic Challenges to Management
Farah Yasmin, Hala Najeeb, Aisha Naeem, Kartik Dapke, Rachana Phadke, Muhammad Sohaib Asghar, Syed Muhammad Ismail Shah, Domenico De Berardis, Irfan Ullah
Diseases. 2021; 9(4): 65
[Pubmed] | [DOI]
57 Risk Factors for Fungal Co-Infections in Critically Ill COVID-19 Patients, with a Focus on Immunosuppressants
Obinna T. Ezeokoli, Onele Gcilitshana, Carolina H. Pohl
Journal of Fungi. 2021; 7(7): 545
[Pubmed] | [DOI]
58 COVID-19-Associated Mucormycosis (CAM): Case-Series and Global Analysis of Mortality Risk Factors
Abanoub Riad, Alshaimaa Ahmed Shabaan, Julien Issa, Sally Ibrahim, Hatem Amer, Yossef Mansy, Islam Kassem, Amira Bisher Kassem, Hans-Peter Howaldt, Miloslav Klugar, Sameh Attia
Journal of Fungi. 2021; 7(10): 837
[Pubmed] | [DOI]
59 Invasive Fungal Infections Complicating COVID-19: A Narrative Review
Giacomo Casalini, Andrea Giacomelli, Annalisa Ridolfo, Cristina Gervasoni, Spinello Antinori
Journal of Fungi. 2021; 7(11): 921
[Pubmed] | [DOI]
60 Novel Pathogenic Mucorales Identified Using the Silkworm Infection Model
Suresh Panthee, Hiroshi Hamamoto, Yayoi Nishiyama, Atmika Paudel, Kazuhisa Sekimizu
Journal of Fungi. 2021; 7(11): 995
[Pubmed] | [DOI]
61 Spike in Rhino-Orbital-Cerebral Mucormycosis Cases Presenting to a Tertiary Care Center During the COVID-19 Pandemic
Yousef A. Fouad, Tougan Taha Abdelaziz, Anas Askoura, Mohamed Ibrahim Saleh, Mohammad S. Mahmoud, Doaa Maamoun Ashour, Manar Maamoun Ashour
Frontiers in Medicine. 2021; 8
[Pubmed] | [DOI]
62 Concurrent and Post COVID-19 Ophthalmological Implications
Tamer EE Wasfy, Mohamed A Eldesouky, Yasser Serag, Hazem A Elbedewy
Clinical Ophthalmology. 2021; Volume 15: 4467
[Pubmed] | [DOI]
63 Rhino-orbital COVID-19 associated mucormycosis- A case report
Shanmuga Vadivoo Natarajan, B Usha
IP International Journal of Medical Microbiology and Tropical Diseases. 2021; 7(4): 304
[Pubmed] | [DOI]
64 Pathogenesis of Respiratory Viral and Fungal Coinfections
Fabián Salazar, Elaine Bignell, Gordon D. Brown, Peter C. Cook, Adilia Warris
Clinical Microbiology Reviews. 2021;
[Pubmed] | [DOI]
65 Epidemiology and Antifungal Susceptibilities of Mucoralean Fungi in Clinical Samples from the United States
Hamid Badali, Connie Cañete-Gibas, Dora McCarthy, Hoja Patterson, Carmita Sanders, Marjorie P. David, James Mele, Hongxin Fan, Nathan P. Wiederhold, Kimberly E. Hanson
Journal of Clinical Microbiology. 2021; 59(9)
[Pubmed] | [DOI]
66 CT Findings of COVID-19–associated Pulmonary Mucormycosis: A Case Series and Literature Review
Mandeep Garg, Nidhi Prabhakar, Valliappan Muthu, Shameema Farookh, Harsimran Kaur, Vikas Suri, Ritesh Agarwal
Radiology. 2021; : 211583
[Pubmed] | [DOI]
67 An epidemic within a pandemic
Niladri Banerjee, Anannya Ray Banerjee, Harshita Agarwal, Harshit Agarwal
Tropical Doctor. 2021; : 0049475521
[Pubmed] | [DOI]
68 COVID-19 associated mucormycosis: the urgent need to reconsider the indiscriminate use of immunosuppressive drugs
Alfonso J. Rodriguez-Morales, Ranjit Sah, Jose Millan-Oñate, Angel Gonzalez, Juan J. Montenegro-Idrogo, Sias Scherger, Carlos Franco-Paredes, Andrés F. Henao-Martínez
Therapeutic Advances in Infectious Disease. 2021; 8: 2049936121
[Pubmed] | [DOI]
69 A case report of rhino-facial mucormycosis in a non-diabetic patient with COVID-19: a systematic review of literature and current update
Faezeh Mohammadi, Milad Badri, Shapoor Safari, Nima Hemmat
BMC Infectious Diseases. 2021; 21(1)
[Pubmed] | [DOI]
70 A multicentric observational study of imaging findings in COVID-19-related rhino-orbito-cerebral mucormycosis: a new Pandora’s box
Annu Singhal, Shikha Jain, Swati Sharma, Vivek Cherumanalil Kottiyath, Girish Khandelwal
Egyptian Journal of Radiology and Nuclear Medicine. 2021; 52(1)
[Pubmed] | [DOI]
71 COVID-19–associated mucormycosis: Evidence-based critical review of an emerging infection burden during the pandemic’s second wave in India
Jesil Mathew Aranjani, Atulya Manuel, Habeeb Ibrahim Abdul Razack, Sam T. Mathew, Susanna Kar Pui Lau
PLOS Neglected Tropical Diseases. 2021; 15(11): e0009921
[Pubmed] | [DOI]
72 Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran
Farzad Pakdel, Kazem Ahmadikia, Mohammadreza Salehi, Azin Tabari, Rozita Jafari, Golfam Mehrparvar, Yasaman Rezaie, Shahin Rajaeih, Neda Alijani, Aleksandra Barac, Alireza Abdollahi, Sadegh Khodavaisy
Mycoses. 2021; 64(10): 1238
[Pubmed] | [DOI]
73 COVID-19-associated mucormycosis: An updated systematic review of literature
Rimesh Pal, Birgurman Singh, Sanjay Kumar Bhadada, Mainak Banerjee, Ranjitpal Singh Bhogal, Neemu Hage, Ashok Kumar
Mycoses. 2021; 64(12): 1452
[Pubmed] | [DOI]
74 Mucormycosis and COVID-19: An epidemic within a pandemic in India
Lav Selarka, Suktara Sharma, Dinesh Saini, Sanjay Sharma, Amit Batra, Vishal T. Waghmare, Pratibha Dileep, Sanket Patel, Monarch Shah, Tejas Parikh, Prakash Darji, Amit Patel, Gaurav Goswami, Anand Shah, Sandeep Shah, Harsh Lathiya, Moksha Shah, Pranita Sharma, Surabhi Chopra, Ankur Gupta, Neha Jain, Erum Khan, Vijay K. Sharma, Arvind K. Sharma, Amanda C. Y. Chan, Jonathan J. Y. Ong
Mycoses. 2021; 64(10): 1253
[Pubmed] | [DOI]
75 Emerging Fungal Infections: New Species, New Names, and Antifungal Resistance
Nathan P Wiederhold
Clinical Chemistry. 2021; 68(1): 83
[Pubmed] | [DOI]
76 Clinical Presentations, Management and Outcomes of Rhino-Orbital-Cerebral Mucormycosis (ROCM) Following COVID-19: A Multi-Centric Study
Tarjani Vivek Dave, Akshay Gopinathan Nair, Raghuraj Hegde, Nidhi Vithalani, Savari Desai, Namrata Adulkar, Saurabh Kamal, Raman Mittal, Renuka A. Bradoo
Ophthalmic Plastic & Reconstructive Surgery. 2021; 37(5): 488
[Pubmed] | [DOI]
77 Impact of COVID-19-associated Mucormycosis in Kidney Transplant Recipients: A Multicenter Cohort Study.
Hari Shankar Meshram, Vivek B. Kute, Dinesh Kumar Yadav, Suraj Godara, Sonal Dalal, Sandeep Guleria, Anil K. Bhalla, Vivek Pathak, Urmila Anandh, Shyam Bansal, Himanshu Patel, Umapati Hegde, Ruchir Dave, Sanshriti Chauhan, Rutul Dave, Deepak Kumar, Tukaram Jamale, Divya Bajpai, Deepesh Kenwar, Keshab Sil, Harsh Vardhan, Manish Balwani, Mayur Patil, Rushi Deshpande, Ashish Nandwani, Pranaw Kumar Jha, Manish Jain, Pratik Das, Vineet Mishra, Dorry L. Segev, Vijay Kher
Transplantation Direct. 2021; 8(1): e1255
[Pubmed] | [DOI]
78 Intracranial Mucormycosis—A Minacious Foe
Sharad Pandey, Abrar Ahad Wani
Indian Journal of Neurosurgery. 2021; 10(02): 092
[Pubmed] | [DOI]
79 COVID-19-associated mucormycosis: Case report and systematic review
Ahmet Dilek, Resat Ozaras, Sevket Ozkaya, Mustafa Sunbul, Elif Itir Sen, Hakan Leblebicioglu
Travel Medicine and Infectious Disease. 2021; 44: 102148
[Pubmed] | [DOI]
80 Spectrum of fungal infections in COVID patients: The double whammy!
Mahima Lall, Kavita Bala Anand, Shelinder Pal Singh Shergill, Aditi Sondhi, Preeti Rai
Medical Journal Armed Forces India. 2021; 77: S527
[Pubmed] | [DOI]
81 Mucormycosis – An opportunistic infection in the aged immunocompromised individual: A reason for concern in COVID-19
Vivek P. Chavda, Vasso Apostolopoulos
Maturitas. 2021; 154: 58
[Pubmed] | [DOI]
82 Mucormycosis: A deadly black fungus infection among COVID-19 patients in India
Naveen Kumar Choudhary, Amit K. Jain, Rupesh Soni, Neha Gahlot
Clinical Epidemiology and Global Health. 2021; 12: 100900
[Pubmed] | [DOI]
83 Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India
Awadhesh Kumar Singh, Ritu Singh, Shashank R. Joshi, Anoop Misra
Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021; 15(4): 102146
[Pubmed] | [DOI]
84 Mucormycosis: An opportunistic pathogen during COVID-19
Iyer Mahalaxmi, Kaavya Jayaramayya, Dhivya Venkatesan, Mohana Devi Subramaniam, Kaviyarasi Renu, Padmavathi Vijayakumar, Arul Narayanasamy, Abilash Valsala Gopalakrishnan, Nachimuthu Senthil Kumar, Palanisamy Sivaprakash, Krothapalli R.S. Sambasiva Rao, Balachandar Vellingiri
Environmental Research. 2021; 201: 111643
[Pubmed] | [DOI]
85 Mucormycosis coinfection in the context of global COVID-19 outbreak: A fatal addition to the pandemic spectrum
Popy Devnath, Kuldeep Dhama, Abu Montakim Tareq, Talha Bin Emran
International Journal of Surgery. 2021; 92: 106031
[Pubmed] | [DOI]
86 The surge in Covid related mucormycosis
Somesh Chandra, Rakesh Rawal
Journal of Infection. 2021; 83(3): 381
[Pubmed] | [DOI]
87 COVID-19 and mucormycosis superinfection: the perfect storm
Jaffar A. Al-Tawfiq, Saad Alhumaid, Abeer N. Alshukairi, Mohamad-Hani Temsah, Mazin Barry, Abbas Al Mutair, Ali A. Rabaan, Awadh Al-Omari, Raghavendra Tirupathi, Manaf AlQahtani, Salma AlBahrani, Kuldeep Dhama
Infection. 2021; 49(5): 833
[Pubmed] | [DOI]
88 Risk Based Decision Algorithms for Management of COVID-19 Associated Rhino-orbital Mucormycosis
Neeti Kapre Gupta, Madan Kapre, Harshkaran Gupta, Gauri Kapre Vaidya, Shripal Jani, Sonal Meshram, Sanjog Singh, Vidula Kapre, R. Ravi, Vilas Tambe, Nirmala Thakkar, Anju Mundhada
Indian Journal of Otolaryngology and Head & Neck Surgery. 2021;
[Pubmed] | [DOI]
89 COVID-19, Diabetes and Steroids: The Demonic Trident for Mucormycosis
Sudhir Bhandari, Shruti Bhargava, Sunil Samdhani, Shashank Nath Singh, Bharat Bhushan Sharma, Sunita Agarwal, Man Prakash Sharma, Srikant Sharma, Vishnu Sharma, Shivankan Kakkar, Amitabh Dube, Mohnish Grover
Indian Journal of Otolaryngology and Head & Neck Surgery. 2021;
[Pubmed] | [DOI]
90 Epidemiology and Pathophysiology of COVID-19-Associated Mucormycosis: India Versus the Rest of the World
Valliappan Muthu, Shivaprakash M. Rudramurthy, Arunaloke Chakrabarti, Ritesh Agarwal
Mycopathologia. 2021; 186(6): 739
[Pubmed] | [DOI]
91 IFN-? Mediated Signaling Improves Fungal Clearance in Experimental Pulmonary Mucormycosis
Amanda Ribeiro dos Santos, Thais Fernanda Fraga-Silva, Débora de Fátima Almeida-Donanzam, Rodolfo Ferreira dos Santos, Angela Carolina Finato, Cleverson Teixeira Soares, Vanessa Soares Lara, Nara Lígia Martins Almeida, Maria Izilda Andrade, Olavo Speranza de Arruda, Maria Sueli Parreira de Arruda, James Venturini
Mycopathologia. 2021;
[Pubmed] | [DOI]
92 Post-COVID-19 rhino-orbito-cerebral mucormycosis: a new addition to challenges in pandemic control
Sandipta Mitra, Mridul Janweja, Arunabha Sengupta
European Archives of Oto-Rhino-Laryngology. 2021;
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
References
Article Tables

 Article Access Statistics
    Viewed9863    
    Printed16    
    Emailed0    
    PDF Downloaded196    
    Comments [Add]    
    Cited by others 92    

Recommend this journal