%A Verma, V %A Kumar, Sanjeev %A Kumar, Arun %A Anand, Ravi %T The Effect of Lignocaine and Metoclopramide Alone and in Combination on Pain after Propofol Intravenous Injection in Adult Surgical Patients Scheduled for Elective Surgery Under General Anaesthesia: A Prospective, Double Blind, Randomized Clinical Study %9 Original Article %D 1990 %J Indian Journal of Ophthalmology %P 14-16 %V 38 %N 1 %U https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=1990;volume=38;issue=1;spage=14;epage=16;aulast=Verma %8 January 1, 1990 %X Introduction: Propofol causes pain on injection in 28% - 90% of patients. A number of techniques have been tried for minimizing propofol induced pain with variable results. Objectives: To compare the use of lignocaine, metoclopramide and metoclopramide &lignocaine combination for the reduction of pain during injection of propofol in adult patients. Design: A prospective, double blind, randomized study. Setting: Department of Anaesthesiology and Critical Care Medicine, Indira Gandhi Institute of Medical Sciences, Patna Period: From June 2007 to March 2008 Materials & Methods: 150 subjects (ASA I-II) scheduled for elective operations under general anaesthesia were allocated into three groups and treated as follows: Group A:40mg lignocaine 2%(2ml) and 2ml normal saline; Group B: 10 mg metoclopramide(2ml) and 2ml normal saline ,Group C 40mg lignocaine 2% &: 10 mg metoclopramide. Pain intensity was graded by a single blinded observer and recorded as either severe, moderate, mild or no pain according to the response of the patients to the injection. Results: The incidence of pain was 46% in metoclopramide group compared to 26% in the lignocaine and 12% in the lignocaine& metoclopramide group. Conclusion: lignocaine & metoclopramide combination is more effective than metoclopramide and lignocaine alone in decreasingthe pain of propofol injection. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 0301-4738