author = {Sihota, R. and Mohan, Madan. and Angra, S. and Mathur, R.}, title = {{Clinico-biochemical study of experimental complicated cataracts}}, journal ={Indian Journal of Ophthalmology}, volume ={39}, number ={4}, pages = {148-150}, year = {1991}, abstract ={Clinically observed complicated cataracts, generally do not have a definite causal factor. We studied the effects of E. coli toxin injected suprachoroidally, to simulate the effect of toxins released by extraocular organisms on the lens. 79.2% of eyes had a definable cataract at the end of the 6th week of observation. The biochemical changes portrayed an increased oxidative activity in the lens, evidenced by a fall in glutathione concentration, and the consequent tertiary reorientation of proteins to increase insoluble proteins, forming a cataract.}, URL ={https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=1991;volume=39;issue=4;spage=148;epage=150;aulast=Sihota;t=6}, eprint ={https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=1991;volume=39;issue=4;spage=148;epage=150;aulast=Sihota;t=6} }