%A Narang, S %A Gupta, V %A Gupta, A %A Dogra, Mangat %A Pandav, Surinder %A Das, S %T Role of prophylactic intravitreal antibiotics in open globe injuries. %9 Original Article %D 2003 %J Indian Journal of Ophthalmology %P 39-44 %V 51 %N 1 %U https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2003;volume=51;issue=1;spage=39;epage=44;aulast=Narang %8 January 1, 2003 %X Purpose: To determine the efficacy of prophylactic intravitreal antibiotics in reducing the incidence of endophthalmitis after trauma. Methods: This was a prospective, randomised, case control study of 70 consecutive patients with open globe injury. The patients were prospectively randomised into group I (32 eyes) and group II (38 eyes). Group I patients were given prophylactic intravitreal injection of vancomycin 1 mg and ceftazidime 2.25 mg at the conclusion of primary repair. Group II patients were not given prophylactic intravitreal antibiotics. All the patients received intravenous ciprofloxacin. Results: The incidence of endophthalmitis was higher in group II (7 of 38 eyes; 18.42%) compared to group I (2 of 32 eyes; 6.25%). Both the patients who developed endophthalmitis despite prophylactic intravitreal antibiotics in group I had an initially undetected intraocular foreign body (eyelash) in the vitreous cavity. Conclusions: Prophylactic intravitreal broad spectrum antibiotic injection decreases the risk of post-traumatic endophthalmitis. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 0301-4738