author = {Vinekar, Anand. and Dogra, Mangat. and Sangtam, Tiakumzuk. and Narang, Anil. and Gupta, Amod.}, title = {{Retinopathy of prematurity in Asian Indian babies weighing greater than 1250 grams at birth: Ten year data from a tertiary care center in a developing country}}, journal ={Indian Journal of Ophthalmology}, volume ={55}, number ={5}, pages = {331-336}, doi = {10.4103/0301-4738.33817}, year = {2007}, abstract ={Background: Retinopathy of prematurity (ROP) is an important cause of childhood blindness in developing countries. Aim: To report the spectrum of ROP and associated risk factors in babies weighing > 1250 g at birth in a developing country. Setting and Design: Institutional, retrospective, non-randomized, observational clinical case series. Materials and Methods : Retrospective analysis (10 years) of 275 eyes (138 babies) with ROP. Statistical Analysis: Qualitative data with the Chi-square test. Quantitative data using the unpaired t test or the ANOVA and further tested using multivariate logistic regression. Results: The mean birth weight was 1533.9 g (range 1251 to 2750 g) and the mean period of gestation was 30.9 weeks (range 26 to 35). One hundred and twenty-four of 275 eyes (45.1%) had threshold or worse ROP. Risk factors for threshold or worse disease were, 'outborn babies' ( P < 0.001), respiratory distress syndrome ( P = 0.007) and exchange transfusion ( P = 0.003). The sensitivity of the American and British screening guidelines to pick up threshold or worse ROP in our study group was 82.4% and 77.4% respectively. Conclusions : Severe ROP is often encountered in babies weighing greater than 1250 g at birth in developing countries. Western screening guidelines may require modifications before application in developing countries.}, URL ={https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2007;volume=55;issue=5;spage=331;epage=336;aulast=Vinekar;t=6}, eprint ={https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2007;volume=55;issue=5;spage=331;epage=336;aulast=Vinekar;t=6} }