RT - Journal
TY - JOUR
A1 - Azad, Rajvardhan
A1 - Vivek, Kumar
A1 - Sharma, Yograj
A1 - Chandra, Parijat
A1 - Sain, Siddarth
A1 - Venkataraman, Anusha
T1 - Ranibizumab as an adjunct to laser for macular edema secondary to branch retinal vein occlusion
YR - 2012/7/1
JF - Indian Journal of Ophthalmology
JO - Indian J Ophthalmol
SP - 263
OP - 266
VO - 60
IS - 4
UL - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2012;volume=60;issue=4;spage=263;epage=266;aulast=Azad;t=5
DO - 10.4103/0301-4738.98701
N2 - Purpose: To compare the safety, efficacy, and dosing regimen of intravitreal ranibizumab as an adjunct to laser therapy for the treatment of macular edema secondary to branch retinal vein occlusion (BRVO). Materials and Methods: Thirty eyes of 30 patients of BRVO of at least 6 weeks duration were randomized into three groups: Group 1 received grid laser treatment alone, Group 2 received a single dose of intravitreal injection of ranibizumab (0.5 mg / 0.05 ml) followed by grid laser treatment on 7 th day following injection, while Group 3 received three loading doses of intravitreal ranibizumab at monthly interval (i.e. 0, 1, & 2 months) + standard laser treatment 7 days after the 1 st injection. Outcome measure noted at 6 months follow-up were the improvement in best-corrected visual acuity (BCVA) and central macular thickness (CMT). Results: At 6 months follow-up, there was an average gain of 12 letters (P=0.05), 17.5 letters (P=0.05) and 19 letters (P=0.05) in groups 1, 2, and 3, respectively, with the decrease in CMT being 208.7 μm (P=0.05), 312.9 μm (P= 0.05) and 326.8 μm (P=0.05), respectively, in these groups. Gain in BCVA of more than 3 lines was noted in 1/10 patients in Group 1(10%) as compared to 3/10 (30%) and 4/10 (40%) patients in groups 2 and 3, respectively. Conclusion: The gain in BCVA and reduction in CMT were better with combination therapy (single- and triple- dose regimen) compared to grid laser alone. Single dose of intravitreal ranibizumab with grid laser seems to be an effective therapy.
ER -