%A Zanetti, Fernando %A Fulco, Enzo Augusto %A Chaves, Fernando Rodrigo %A da Costa Pinto, Alexandre %A Arieta, Carlos Eduardo %A Lira, Rodrigo Pessoa %T Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: A randomized trial %9 Original Article %D 2012 %J Indian Journal of Ophthalmology %R 10.4103/0301-4738.98705 %P 277-281 %V 60 %N 4 %U https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2012;volume=60;issue=4;spage=277;epage=281;aulast=Zanetti %8 July 1, 2012 %X Purpose: To compare the effects of preoperative use of topical anti-inflammatory prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery. Design: Randomized clinical trial. Materials and Methods: This single-center, masked, randomized clinical study comprised 140 patients scheduled for cataract surgery. Patients (35 in each group) were randomized to receive placebo, prednisolone acetate, ketorolac tromethamine 0.4% or nepafenac. These eye drops were administered three times daily for the two days prior to surgery. The pupillary diameters were measured by the surgeon using a compass prior to the corneal section and at the end of surgery. The primary outcome was the number of patients with pupil ≥ 6mm at the end of the surgery; the secondary outcome was the number of patients with pupil ≥ 6mm at the beginning of the surgery. Results: All the patients achieved pupil ≥ 6mm at the beginning of the surgery. The number of patients in the prednisolone (29/35), nepafenac (31/35) and ketorolac (30/35) groups with pupil ≥ 6mm was greater than in the placebo group in the maintenance of intraoperative mydriasis (19/35 - P =0.003). There was no statistical difference among the prednisolone, nepafenac and ketorolac groups in the maintenance of intraoperative mydriasis (P =.791). There were no complications during surgery or related to the preoperative use of the eye drops. Conclusion: Preoperative use of ketorolac, prednisolone and nepafenac was effective in maintaining intraoperative mydriasis when compared with placebo. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 0301-4738