TY - JOUR
A1 - Kocabeyoglu, Sibel
A1 - Mocan, Mehmet
A1 - Haznedaroglu, Ibrahim
A1 - Uner, Aysegul
A1 - Uzunosmanoglu, Enes
A1 - Irkec, Murat
T1 - In vivo confocal microscopic characteristics of crystalline keratopathy in patients with monoclonal gammopathy: Report of two cases
Y1 - 2014/9/1
JF - Indian Journal of Ophthalmology
JO - Indian J Ophthalmol
SP - 938
EP - 940
VL - 62
IS - 9
UR - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2014;volume=62;issue=9;spage=938;epage=940;aulast=Kocabeyoglu
DO - 10.4103/0301-4738.143933
N2 - In this paper, we report two cases of a 62-year-old patient presented with blurred vision and a 45-year-old male diagnosed with multiple myeloma who was referred from the Department of Oncology. Slit-lamp examination, in vivo confocal microscopy (IVCM), systemic work-up and serum protein electrophoresis were obtained. In both patients, slit-lamp findings revealed bilateral diffuse subepithelial and anterior stromal crystals and IVCM showed highly reflective deposits in the corneal epithelium and stroma. The first patient was eventually diagnosed with monoclonal gammopathy of undetermined significance following bone marrow biopsy and systemic evaluation. Unusual corneal deposits may constitute the first sign of monoclonal gammopathies. IVCM may be helpful in showing the crystalline nature of the corneal deposits and guiding the clinician to the diagnosis of gammopathies. Both ophthalmologists and oncologists should be aware that corneal deposits may herald a life-threatening hematologic disease.
ER -