TY - JOUR A1 - Kesarwani, Divya A1 - Rizvi, Syed A1 - Khan, Adeeb A1 - Amitava, Abadan A1 - Vasenwala, Shaista A1 - Siddiqui, Ziya T1 - Tear film and ocular surface dysfunction in diabetes mellitus in an Indian population Y1 - 2017/4/1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 301 EP - 304 VL - 65 IS - 4 UR - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2017;volume=65;issue=4;spage=301;epage=304;aulast=Kesarwani DO - 10.4103/ijo.IJO_939_15 N2 - Purpose: Ophthalmic complications in diabetes such as retinopathy, cataract, and infections have been extensively studied. Recently, attention has been drawn toward ocular surface changes in diabetes mellitus (DM). This study has been carried out to investigate the tear film and ocular surface abnormalities in type II DM patients. Materials and Methods: A total of 83 participants (130 eyes) were enrolled: 53 diabetics (80 eyes) and 30 healthy controls (50 eyes). Of the 53 diabetics, 24 patients (42 eyes) had some diabetic retinopathy. The tear film and ocular surface were evaluated using Schirmer test, tear film break-up time (TBUT), keratoepitheliopathy score (KES), Rose Bengal Staining (RBS) test, and conjunctival impression cytology. Results: When compared with the healthy controls, diabetics showed significantly reduced Schirmer, TBUT measurements and the higher grades of KES and RBS test (P < 0.001). Impression cytology analysis showed goblet cell loss and conjunctival squamous metaplasia in diabetics. Conclusion: Tear film abnormality is a significant feature of diabetic ocular surface diseases. These abnormalities are likely on account of poor quality and function of tears, combined with the subnormal ocular surface. Therefore, all diabetic patients especially those with evidence of retinopathy changes should undergo routine early examination and follow-up of tear function and ocular surface parameters. ER -