%A Rishi, Pukhraj %A Sharma, Tarun %A Sharma, Minal %A Maitray, Aditya %A Dhami, Abhinav %A Aggarwal, Vishvesh %A Munusamy, Saravanan %A Ravikumar, R %A Ramamurthy, Satheesh %T Intra-arterial chemotherapy for retinoblastoma: Two-year results from tertiary eye-care center in India %9 Original Article %D 2017 %J Indian Journal of Ophthalmology %R 10.4103/ijo.IJO_843_16 %P 311-315 %V 65 %N 4 %U https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2017;volume=65;issue=4;spage=311;epage=315;aulast=Rishi %8 April 1, 2017 %X Aim: The aim of this study is to describe treatment outcomes and complications of selective intra-arterial chemotherapy (IAC) for intraocular retinoblastoma (RB). Materials and Methods: A retrospective, interventional series of 10 eyes with RB which underwent IAC using melphalan (5 mg/7.5 mg) and topotecan (1 mg), or melphalan (5 mg/7.5 mg) alone. Treatment outcomes were evaluated in terms of tumor control, vitreous seeds (VS) and subretinal seeds (SRS) control, and globe salvage rates. Results: Ten eyes of 10 patients underwent 38 IAC sessions (mean = 3.8; median = 4; range = 3–5 sessions). Following IAC, complete regression of main tumor was seen in 9 eyes (90%) and partial regression in 1 (10%). All four eyes with SRS showed complete regression (100%). Of 5 eyes with VS, 3 eyes (60%) showed complete regression, 1 eye (20%) showed relapse, while 1 eye (20%) showed no response. Globe salvage was achieved in 8 of 10 eyes (80%). Complications included transient ophthalmic artery narrowing (n = 2), branched retinal vein occlusion (n = 1), forehead skin pigmentation (n = 1), and vitreous hemorrhage (n = 2). There was no case of stroke, hemiplegia, metastasis, or death. Transient hematological changes included relative pancytopenia (n = 4), relative leukopenia (n = 5), and relative thrombocytopenia (n = 4). Mean follow-up was 26 months (median = 28, range = 13–36) from the initiation of first IAC. Conclusions: IAC is an effective therapy for globe preservation in eyes with intraocular RB, in the setting of a developing country like India. Larger studies with longer follow-up are required to validate these results. %0 Journal Article %I Wolters Kluwer Medknow Publications %@ 0301-4738