RT - Journal TY - JOUR A1 - Manjandavida, Fairooz A1 - Stathopoulos, Christina A1 - Zhang, Jing A1 - Honavar, Santhosh A1 - Shields, Carol T1 - Intra-arterial chemotherapy in retinoblastoma – A paradigm change YR - 2019/6/1 JF - Indian Journal of Ophthalmology JO - Indian J Ophthalmol SP - 740 OP - 754 VO - 67 IS - 6 UL - https://journals.lww.com/ijo/pages/default.aspx/article.asp?issn=0301-4738;year=2019;volume=67;issue=6;spage=740;epage=754;aulast=Manjandavida;t=5 DO - 10.4103/ijo.IJO_866_19 N2 - Intra-arterial chemotherapy (IAC), also known as superselective ophthalmic artery chemotherapy or chemosurgery, is currently widely accepted as one of the primary treatment modalities for intraocular retinoblastoma worldwide. Following the introduction of the technique in 1998, IAC has evolved over the past decades to be safer and more effective. Accumulated evidence shows that IAC is more effective in providing eye salvage in group D and E retinoblastoma as compared to conventional systemic intravenous chemotherapy (IVC). In contrast to IVC, IAC has the added benefits of reduced overall treatment duration and minimal systemic toxicity. This review provides a comprehensive update on the history, technique, indications, contraindications, and outcome of IAC. We have also identified the strengths, weaknesses, opportunities and threats (SWOT analysis) of the technique in this review. ER -