Indian Journal of Ophthalmology

: 1977  |  Volume : 25  |  Issue : 2  |  Page : 3--4

Serum immunoglobulins in phlyctenulosis

RN Tyagi, V Thakur, Ratan Mala Gupta 
 Banaras Hindu University, Varanasi, India

Correspondence Address:
R N Tyagi
Department of Ophthalmology, M.M.G. 4, Chhittupur Doctors«SQ» Enclave, B.H.U., Varanasi-221005 (UP).

How to cite this article:
Tyagi R N, Thakur V, Gupta RM. Serum immunoglobulins in phlyctenulosis.Indian J Ophthalmol 1977;25:3-4

How to cite this URL:
Tyagi R N, Thakur V, Gupta RM. Serum immunoglobulins in phlyctenulosis. Indian J Ophthalmol [serial online] 1977 [cited 2021 Jun 17 ];25:3-4
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Full Text

Several recent reports are available in literature regarding serum immunoglobulin in eye diseases like uveitis, Eale's, trachoma and keratitis.[1] However, not a single report could be found related to Phlyctenulosis. Serum immunoglobulins (G, A & M) were estimated to find out whether there was a change in the levels in phlyctenular cases.

 Materials and Methods

Twenty-nine healthy individuals (Group A) and twenty-nine cases of phlyctenulosis (Group B) were subjected to this study. Cases in both groups belonged to same age group.

Besides other routine investigations, the serum im­munoglobulins were estimated by single radial diffusion method.


[Table 1] shows the levels of serum im­munologlobulin G, A and M in individual cases of phlyctenulosis.

Statistically there is highly significant rise in serum IgG level (P=<0.001) and significant rise in IgM level (P= <0.05) in cases of phlyc­tenulosis [Table 2]


The differential analysis of various serum immunogobulins in normal subjects in our study reveals that mean values of different fractions more or less approximated with those reported by Hobbs and Hepner[3], Sehgal and Aikat[4] and Gupta et al.[2]

In phlyctenulosis cases the serum immuno­globulin G and M are found to be at significantly higher levels (P=


Estimation of serum immunoglobulin G, A and M was carried out in 29 healthy indivi­duals and 29 cases of phlyctenulosis. The serum IgG and IgM were sigificantly raised in cases of phlyctenulosis as compared to normal subjects.


We thank Mr. R.J. Verma for his kind help in this study.


1Fahey, J.L.. 1968. W.H.O. Immunology Work­shop notes. All India Institute of Medical sciences, New Delhi, India.
2Gupta. R.M.. Gupta. V,M. and Marwah. S.M.. 1975. Ind. Jour. Med. Res., 63, 1055.
3Hobbs. J.R. and Hepner. G.M.. 1968. Lancet , 217.
4Sehgal, S. and Aikat, B.K., 1970, Ind. Jour. Med. Res., 58, 289.